Detalhe da pesquisa
1.
Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies.
Cell
; 186(16): 3350-3367.e19, 2023 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37421950
2.
FSH blockade improves cognition in mice with Alzheimer's disease.
Nature
; 603(7901): 470-476, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35236988
3.
Gut inflammation triggers C/EBPß/δ-secretase-dependent gut-to-brain propagation of Aß and Tau fibrils in Alzheimer's disease.
EMBO J
; 40(17): e106320, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34260075
4.
Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features.
EMBO J
; 40(3): e105537, 2021 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33351190
5.
Helicobacter hepaticus augmentation triggers Dopaminergic degeneration and motor disorders in mice with Parkinson's disease.
Mol Psychiatry
; 28(3): 1337-1350, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36543925
6.
Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer's disease pathogenesis.
Proc Natl Acad Sci U S A
; 118(25)2021 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34140411
7.
Treatments with the specific δ-secretase inhibitor, compound 11, promote the regeneration of motor and sensory axons after peripheral nerve injury.
Eur J Neurosci
; 58(6): 3555-3568, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37608574
8.
High-fat diet-induced diabetes couples to Alzheimer's disease through inflammation-activated C/EBPß/AEP pathway.
Mol Psychiatry
; 27(8): 3396-3409, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35546632
9.
Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson's disease.
Proc Natl Acad Sci U S A
; 117(39): 24503-24513, 2020 09 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32929029
10.
α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease.
EMBO J
; 37(12)2018 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29769405
11.
δ-Secretase-cleaved Tau stimulates Aß production via upregulating STAT1-BACE1 signaling in Alzheimer's disease.
Mol Psychiatry
; 26(2): 586-603, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30382187
12.
Mitochondrial dysfunction triggers the pathogenesis of Parkinson's disease in neuronal C/EBPß transgenic mice.
Mol Psychiatry
; 26(12): 7838-7850, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34489530
13.
A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer's disease pathologies.
Brain
; 144(6): 1833-1852, 2021 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33880508
14.
ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer's disease.
Acta Neuropathol
; 142(1): 139-158, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33895869
15.
The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer's disease.
Proc Natl Acad Sci U S A
; 115(3): 578-583, 2018 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29295929
16.
Akt Phosphorylates NQO1 and Triggers its Degradation, Abolishing Its Antioxidative Activities in Parkinson's Disease.
J Neurosci
; 39(37): 7291-7305, 2019 09 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31358653
17.
TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson's disease.
Proc Natl Acad Sci U S A
; 114(40): 10773-10778, 2017 10 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28923922
18.
α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.
Proc Natl Acad Sci U S A
; 114(5): 1183-1188, 2017 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-28096359
19.
Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice.
J Neurosci
; 32(27): 9277-87, 2012 Jul 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22764235
20.
Endogenous CNTF mediates stroke-induced adult CNS neurogenesis in mice.
Neurobiol Dis
; 49: 68-78, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22960105