Detalhe da pesquisa
1.
The Cellular Phase of Alzheimer's Disease.
Cell
; 164(4): 603-15, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26871627
2.
New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases.
EMBO J
; 43(6): 887-903, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38396302
3.
Endothelial Cells Are Heterogeneous in Different Brain Regions and Are Dramatically Altered in Alzheimer's Disease.
J Neurosci
; 43(24): 4541-4557, 2023 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37208174
4.
Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aß and tau.
Acta Neuropathol
; 147(1): 65, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38557897
5.
Distinct transcriptomic responses to Aß plaques, neurofibrillary tangles, and APOE in Alzheimer's disease.
Alzheimers Dement
; 20(1): 74-90, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37461318
6.
MEK1/2 activity modulates TREM2 cell surface recruitment.
J Biol Chem
; 296: 100218, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33839686
7.
Precision pharmacology for Alzheimer's disease.
Pharmacol Res
; 130: 331-365, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29458203
8.
The amyloid cascade hypothesis: are we poised for success or failure?
J Neurochem
; 139 Suppl 2: 237-252, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27255958
9.
The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.
EMBO J
; 31(10): 2261-74, 2012 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22505025
10.
An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease.
J Biol Chem
; 288(32): 23331-47, 2013 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-23798682
11.
Broad proteomics analysis of seeding-induced aggregation of α-synuclein in M83 neurons reveals remodeling of proteostasis mechanisms that might contribute to Parkinson's disease pathogenesis.
Mol Brain
; 17(1): 26, 2024 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38778381
12.
Endothelial Cells are Heterogeneous in Different Brain Regions and are Dramatically Altered in Alzheimer's Disease.
bioRxiv
; 2023 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36824974
13.
Distinct Transcriptomic Responses to Aß plaques, Neurofibrillary Tangles, and APOE in Alzheimer's Disease.
bioRxiv
; 2023 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36993332
14.
Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1.
J Biol Chem
; 286(10): 8677-8687, 2011 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-21209097
15.
Antiamyloid therapy for Alzheimer's disease--are we on the right road?
N Engl J Med
; 370(4): 377-8, 2014 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-24450897
16.
The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics.
Nat Rev Drug Discov
; 21(4): 306-318, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35177833
17.
Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model.
iScience
; 25(1): 103658, 2022 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35072001
18.
Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer's disease model.
Sci Rep
; 11(1): 2879, 2021 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33536571
19.
A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease.
Ann Neurol
; 76(2): 185-205, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24853080
20.
Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration.
Front Immunol
; 11: 579000, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33162994