Detalhe da pesquisa
1.
The MYPT2-regulated striated muscle-specific myosin light chain phosphatase limits cardiac myosin phosphorylation in vivo.
J Biol Chem
; 300(2): 105652, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38224947
2.
Molecular basis of force-pCa relation in MYL2 cardiomyopathy mice: Role of the super-relaxed state of myosin.
Proc Natl Acad Sci U S A
; 119(8)2022 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35177471
3.
Efficacy of a growth hormone-releasing hormone agonist in a murine model of cardiometabolic heart failure with preserved ejection fraction.
Am J Physiol Heart Circ Physiol
; 324(6): H739-H750, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36897749
4.
Hydroxychloroquine Mitigates Dilated Cardiomyopathy Phenotype in Transgenic D94A Mice.
Int J Mol Sci
; 23(24)2022 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36555229
5.
Mavacamten decreases maximal force and Ca2+ sensitivity in the N47K-myosin regulatory light chain mouse model of hypertrophic cardiomyopathy.
Am J Physiol Heart Circ Physiol
; 320(2): H881-H890, 2021 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33337957
6.
Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice.
Proc Natl Acad Sci U S A
; 115(10): E2338-E2347, 2018 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29463717
7.
Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain.
FASEB J
; 33(3): 3152-3166, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30365366
8.
Insights into myosin regulatory and essential light chains: a focus on their roles in cardiac and skeletal muscle function, development and disease.
J Muscle Res Cell Motil
; 41(4): 313-327, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31131433
9.
Hereditary heart disease: pathophysiology, clinical presentation, and animal models of HCM, RCM, and DCM associated with mutations in cardiac myosin light chains.
Pflugers Arch
; 471(5): 683-699, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30706179
10.
Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice.
Proc Natl Acad Sci U S A
; 112(30): E4138-46, 2015 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26124132
11.
N-Terminus of Cardiac Myosin Essential Light Chain Modulates Myosin Step-Size.
Biochemistry
; 55(1): 186-98, 2016 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26671638
12.
Gene expression patterns in transgenic mouse models of hypertrophic cardiomyopathy caused by mutations in myosin regulatory light chain.
Arch Biochem Biophys
; 601: 121-32, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26906074
13.
Myosin regulatory light chain phosphorylation enhances cardiac ß-myosin in vitro motility under load.
Arch Biochem Biophys
; 580: 14-21, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26116789
14.
Proteomic analysis of physiological versus pathological cardiac remodeling in animal models expressing mutations in myosin essential light chains.
J Muscle Res Cell Motil
; 36(6): 447-61, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26668058
15.
Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice.
J Mol Cell Cardiol
; 74: 318-29, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24992035
16.
Mechanistic basis for rescuing hypertrophic cardiomyopathy with myosin regulatory light chain phosphorylation.
Cytoskeleton (Hoboken)
; 2024 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38494592
17.
Deletion of 1-43 amino acids in cardiac myosin essential light chain blunts length dependency of Ca(2+) sensitivity and cross-bridge detachment kinetics.
Am J Physiol Heart Circ Physiol
; 304(2): H253-9, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23144314
18.
Discrete effects of A57G-myosin essential light chain mutation associated with familial hypertrophic cardiomyopathy.
Am J Physiol Heart Circ Physiol
; 305(4): H575-89, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23748425
19.
Myosin regulatory light chain mutation found in hypertrophic cardiomyopathy patients increases isometric force production in transgenic mice.
Biochem J
; 442(1): 95-103, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22091967
20.
Cardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent biochemistry.
Proc Natl Acad Sci U S A
; 107(40): 17403-8, 2010 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20855589