Detalhe da pesquisa
1.
Stereoselective Amine Synthesis Mediated by a Zirconocene Hydride to Accelerate a Drug Discovery Program.
J Org Chem
; 89(6): 3875-3882, 2024 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38422508
2.
Selected Approaches to Disrupting Protein-Protein Interactions within the MAPK/RAS Pathway.
Int J Mol Sci
; 24(8)2023 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37108538
3.
Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors.
Bioorg Med Chem
; 71: 116947, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35926325
4.
Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-like Biology.
J Am Chem Soc
; 138(40): 13415-13423, 2016 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27676096
5.
Synthesis of seco-B-ring bryostatin analogue WN-1 via C-C bond-forming hydrogenation: critical contribution of the B-ring in determining bryostatin-like and phorbol 12-myristate 13-acetate-like properties.
J Am Chem Soc
; 136(38): 13209-16, 2014 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25207655
6.
Catalytic enantioselective C-H functionalization of alcohols by redox-triggered carbonyl addition: borrowing hydrogen, returning carbon.
Angew Chem Int Ed Engl
; 53(35): 9142-50, 2014 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25056771
7.
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography.
J Med Chem
; 67(1): 774-781, 2024 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38156904
8.
The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading.
Mol Cancer Ther
; 2024 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38641404
9.
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein.
J Med Chem
; 67(6): 4936-4949, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38477582
10.
Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits.
RSC Med Chem
; 13(12): 1549-1564, 2022 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36545438
11.
Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5â¢MTA Complex for the Treatment of MTAP-Deleted Cancers.
J Med Chem
; 65(3): 1749-1766, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35041419
12.
Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction.
J Med Chem
; 65(14): 9678-9690, 2022 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35833726
13.
Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors.
J Med Chem
; 63(15): 8584-8607, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32667798
14.
Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment.
J Med Chem
; 62(13): 6190-6213, 2019 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31259550
15.
CCR4 Antagonists Inhibit Treg Trafficking into the Tumor Microenvironment.
ACS Med Chem Lett
; 9(10): 953-955, 2018 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30344896
16.
Controlling regiochemistry in the gold-catalyzed synthesis of unsaturated spiroketals.
Org Lett
; 16(20): 5320-3, 2014 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25271554
17.
The tandem intermolecular hydroalkoxylation/Claisen rearrangement.
Chem Commun (Camb)
; 49(39): 4157-9, 2013 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23160013