Detalhe da pesquisa
1.
Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer.
Proc Natl Acad Sci U S A
; 114(12): 3127-3132, 2017 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28270606
2.
Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress.
Genes Dev
; 25(10): 1041-51, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21576264
3.
Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK.
Bioorg Med Chem Lett
; 26(15): 3562-6, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27335255
4.
Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3'-indolin]-2'-ones as potent PLK4 inhibitors with oral antitumor efficacy.
Bioorg Med Chem Lett
; 26(19): 4625-4630, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27592744
5.
Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.
Bioorg Med Chem
; 22(17): 4968-97, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25043312
6.
The spindle assembly checkpoint is a therapeutic vulnerability of CDK4/6 inhibitor-resistant ER+ breast cancer with mitotic aberrations.
Sci Adv
; 8(36): eabq4293, 2022 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36070391
7.
An evolved ribosome-inactivating protein targets and kills human melanoma cells in vitro and in vivo.
Mol Cancer
; 9: 28, 2010 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20128926
8.
Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent.
ACS Med Chem Lett
; 7(7): 671-5, 2016 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27437075
9.
The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.
J Med Chem
; 58(1): 130-46, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24867403
10.
The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent.
J Med Chem
; 58(1): 147-69, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25723005
11.
The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents.
J Med Chem
; 58(8): 3366-92, 2015 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25763473
12.
Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent.
Cancer Cell
; 26(2): 163-76, 2014 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25043604
13.
The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents.
J Med Chem
; 56(15): 6069-87, 2013 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23829549