RESUMO
During April 2011-March 2012, we retrospectively reviewed medical records for South Korea soldiers to assess the etiology and epidemiology of acute viral lower respiratory tract infections. Adenovirus was the most commonly identified virus (63.2%) and the most common cause of pneumonia (79.3%) and hospitalization (76.6%); 3 soldiers died of adenovirus-related illness.
Assuntos
Militares , Infecções Respiratórias/epidemiologia , Doença Aguda , Adolescente , Adulto , Feminino , História do Século XXI , Hospitalização , Humanos , Masculino , República da Coreia , Infecções Respiratórias/história , Estudos Retrospectivos , Estações do Ano , Viroses/diagnóstico , Viroses/epidemiologia , Adulto JovemRESUMO
BACKGROUND AND AIM: We analyzed the characteristics of gastrointestinal neuroendocrine tumors and examined the outcomes and safety of modalities in rectal neuroendocrine tumors. METHODS: Between 2007 and 2011, a total of 91 patients with gastrointestinal neuroendocrine tumors were retrospectively reviewed in terms of the characteristics of tumors. RESULTS: Sixty-six patients had rectal neuroendocrine tumors and underwent endoscopic mucosal resection (EMR, n = 29), endoscopic submucosal dissection (ESD, n = 23), or transanal endoscopic microsurgery (TEM, n = 14). The complete resection rate was higher in the ESD group (82.7%) and in the TEM group (100%) compared to the EMR group (65.5%) (P < 0.046). The complication rate was higher in the ESD group (47.8%) than in the EMR group (18.5%) (P = 0.003). No local tumor recurrence was observed in all patients, regardless of the procedure, during the median follow-up period of 21.5 ± 13.5 months. CONCLUSIONS: ESD achieved a higher complete resection rate than EMR and comparable to TEM. Tumor recurrence was not observed in the endoscopic resection and TEM groups, regardless of the completeness of resection. Small neuroendocrine tumors of the gastrointestinal tract can be managed reliably with both endoscopic resection and TEM.
Assuntos
Endoscopia Gastrointestinal/métodos , Mucosa Intestinal/cirurgia , Tumores Neuroendócrinos/cirurgia , Neoplasias Retais/cirurgia , Idoso , Dissecação/métodos , Feminino , Humanos , Mucosa Intestinal/patologia , Masculino , Microcirurgia , Pessoa de Meia-Idade , Tumores Neuroendócrinos/patologia , Complicações Pós-Operatórias/epidemiologia , Neoplasias Retais/patologia , República da Coreia/epidemiologia , Resultado do TratamentoRESUMO
Lymphangioma is an uncommon malformation of lymphatic system. Multiple colonic lymphangioma named as lymphangiomatosis is considered an extremely rare disease. Although lymphangioma is a benign tumor and most colonic lymphangiomas do not cause symptoms and do not require treatment, resection of lymphangioma is necessary in the presence of symptoms such as abdominal pain, bleeding, intussusceptions. We report a case of colonic lymphangiomatosis in a man who presented with abdominal discomfort and anemia, which was diagnosed and treated with endoscopic snare polypectomy.
Assuntos
Anemia/etiologia , Neoplasias do Colo/complicações , Linfangioma/complicações , Dor Abdominal/etiologia , Anemia/patologia , Anemia/cirurgia , Neoplasias do Colo/patologia , Neoplasias do Colo/cirurgia , Colonoscopia , Humanos , Mucosa Intestinal/patologia , Mucosa Intestinal/cirurgia , Linfangioma/patologia , Linfangioma/cirurgia , Masculino , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
Crohn's disease and ulcerative colitis are well known risk factors of intestinal cancer in relation to the extent and duration of disease. Rarely, small bowel cancer can develop after a longstanding inflammation of Crohn's disease with a relatively higher incidence than the general population. Signet ring cell carcinoma is a rare condition among intestinal cancers, and the diagnosis or detection is more difficult if the cancer originates from the small bowel. We report a case of a 30-year old female in whom signet ring cell carcinoma of ileum was diagnosed after a 15-year history of Crohn's disease.
Assuntos
Carcinoma de Células em Anel de Sinete/diagnóstico , Doença de Crohn/complicações , Neoplasias do Íleo/diagnóstico , Adulto , Carcinoma de Células em Anel de Sinete/etiologia , Carcinoma de Células em Anel de Sinete/patologia , Colonoscopia , Doença de Crohn/diagnóstico , Doença de Crohn/patologia , Feminino , Humanos , Neoplasias do Íleo/etiologia , Neoplasias do Íleo/patologia , Tomografia Computadorizada por Raios XRESUMO
BACKGROUND/AIMS: Serrated adenomas of the colon show mixed characteristics of both hyperplastic and adenomatous polyps. Serrated adenomas are known to progress via the serrated pathway than the adenoma-carcinoma pathway. The aim of this study was to evaluate the characteristics of traditional serrated adenomas compared to hyperplastic polyps and tubular adenomas by using immunohistochemical staining for p53, Bcl-2, and Ki-67. METHODS: Age, sex, location, size and the immunoexpression of p53, Bcl-2, and Ki-67 were retrospectively analyzed in 20 traditional serrated adenomas, 20 hyperplastic polyps, and 20 tubular adenomas from January 2007 to December 2012 at The Catholic University of Korea, Yeouido St. Mary's Hospital. RESULTS: There was no difference in Bcl-2 and p53 expression between traditional serrated adenomas and hyperplastic polyps. Ki-67 Expression of traditional serrated adenomas was higher than that of hyperplastic polyps (p=0.001). Ki-67 and p53 expression was similar between traditional serrated and tubular adenomas. Bcl-2 expression of traditional serrated adenomas was lower than that of tubular adenomas (p=0.001). Regarding the expression of p53, Bcl-2, and Ki-67 in traditional serrated adenomas, there were no statistical differences among age, sex, location, and size. CONCLUSIONS: Our study suggested that Ki-67 may be helpful in distinguishing traditional serrated adenomas from hyperplastic polyps, and p53 expression may be ineffective in distinguishing between traditional serrated and tubular adenomas. From Bcl-2 expression, it is suggested that the tumorigenesis of traditional serrated adenomas is lower than that of tubular adenomas.
Assuntos
Adenoma/fisiopatologia , Neoplasias Colorretais/fisiopatologia , Regulação Neoplásica da Expressão Gênica , Antígeno Ki-67/genética , Proteínas Proto-Oncogênicas c-bcl-2/genética , Proteína Supressora de Tumor p53/genética , Adenoma/genética , Adenoma/metabolismo , Idoso , Pólipos do Colo/fisiopatologia , Neoplasias Colorretais/genética , Neoplasias Colorretais/metabolismo , Feminino , Humanos , Imuno-Histoquímica , Antígeno Ki-67/metabolismo , Masculino , Pessoa de Meia-Idade , Proteínas Proto-Oncogênicas c-bcl-2/metabolismo , Estudos Retrospectivos , Proteína Supressora de Tumor p53/metabolismoRESUMO
An 85 year male patient complaining epigastric discomfort was admitted. From the esophagogastroduodenoscopy, three early gastric cancer (EGCa) lesions had been identified and these were diagnosed as adenocarcinoma with poorly differentiated cell type. The patient underwent operation. From the post-operative mapping, however, additional 4 EGCa lesions were found, and the patient was diagnosed with 7 synchronous EGCa. Out of the 7 EGCa lesions, 6 had shown invasion only to the mucosal layer and one had shown invasion into the 1/3 layer of submucosa. In spite of such superficial invasions, 28 of 48 lymph nodes had been identified as metastases. The multiple lesions of EGCa do not increase the risk of lymph node metastasis, but if their differentiations are poor or if they have lympho-vascular invasion, multiple lymph node metastases could incur even if the depth of invasion is limited to the mucosal layer or the upper portion of the submucosal layer.
Assuntos
Adenocarcinoma/secundário , Neoplasias Primárias Múltiplas/patologia , Neoplasias Gástricas/patologia , Adenocarcinoma/cirurgia , Idoso de 80 Anos ou mais , Diferenciação Celular , Endoscopia Gastrointestinal , Gastrectomia , Humanos , Excisão de Linfonodo , Metástase Linfática , Masculino , Invasividade Neoplásica , Neoplasias Primárias Múltiplas/cirurgia , Neoplasias Gástricas/cirurgiaRESUMO
BACKGROUND/AIMS: Subepithelial tumors are occasionally found during upper gastrointestinal endoscopy. The purpose of this study was to evaluate endoscopic characteristics of mesenchymal tumors originating from muscularis mucosa or muscularis propria. METHODS: A total of 307 mesenchymal tumors of the upper gastrointestinal tract were diagnosed between March 2006 and February 2012 at Yeouido St. Mary's Hospital (Seoul, Korea). Data on endoscopic and endoscopic ultrasonographic findings were collected and analyzed by retrospectively reviewing the medical records. RESULTS: The mean size of the mesenchymal tumors originating from muscularis mucosa was significantly smaller than those originating from muscularis propria (10.5±6.9 mm vs. 14.3±13.9 mm, p=0.035). The most common locations of the mesenchymal tumors originating from muscularis mucosa and muscularis propria were esophagus (69.1%) and body of the stomach (43.3%), respectively (p<0.001). Rolling sign was more commonly observed with mesenchymal tumors originating from muscularis mucosa (80.4%, p=0.001), and cushion sign was more frequently absent with those originating from muscularis propria (72.4%, p<0.001). Internal echo was homogenous in 89.7% and 81.9% of mesenchymal tumors originating from muscularis mucosa and muscularis propria, respectively (p=0.092). CONCLUSIONS: The size, location, and movability of mesenchymal tumors originating from muscularis mucosa were different from those of mesenchymal tumor originating from muscularis propria.propria.