Detalhe da pesquisa
1.
The contribution of extrachromosomal DNA to genome plasticity in malaria parasites.
Mol Microbiol
; 115(4): 503-507, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33103309
2.
Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors.
Antimicrob Agents Chemother
; 66(10): e0081722, 2022 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36094216
3.
Rapid antigen diversification through mitotic recombination in the human malaria parasite Plasmodium falciparum.
PLoS Biol
; 17(5): e3000271, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31083650
4.
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.
Proc Natl Acad Sci U S A
; 115(29): E6863-E6870, 2018 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29967165
5.
Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice.
Angew Chem Int Ed Engl
; 60(17): 9279-9283, 2021 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33433953
6.
A Histone Methyltransferase Inhibitor Can Reverse Epigenetically Acquired Drug Resistance in the Malaria Parasite Plasmodium falciparum.
Antimicrob Agents Chemother
; 64(6)2020 05 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32179524
7.
Clinical and Molecular Evidence of Atovaquone and Azithromycin Resistance in Relapsed Babesia microti Infection Associated With Rituximab and Chronic Lymphocytic Leukemia.
Clin Infect Dis
; 65(7): 1222-1225, 2017 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28541469
8.
Babesia microti: from Mice to Ticks to an Increasing Number of Highly Susceptible Humans.
J Clin Microbiol
; 55(10): 2903-2912, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28747374
9.
Plasmodium falciparum K76T pfcrt Gene Mutations and Parasite Population Structure, Haiti, 2006-2009.
Emerg Infect Dis
; 22(5): 786-93, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-27089479
10.
Malaria parasites utilize both homologous recombination and alternative end joining pathways to maintain genome integrity.
Nucleic Acids Res
; 42(1): 370-9, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24089143
11.
Origin of robustness in generating drug-resistant malaria parasites.
Mol Biol Evol
; 31(7): 1649-60, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24739308
12.
Direct evidence for the adaptive role of copy number variation on antifolate susceptibility in Plasmodium falciparum.
Mol Microbiol
; 88(4): 702-12, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23347134
13.
Protocol for analysis of intracellular conversion of artezomib molecules into new proteasome inhibitors in Plasmodium falciparum parasites.
STAR Protoc
; 5(1): 102896, 2024 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38363687
14.
Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors.
Nat Commun
; 14(1): 8302, 2023 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38097652
15.
Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome InhibitorsâPart II.
J Med Chem
; 66(2): 1484-1508, 2023 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36630286
16.
Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance.
Cell Chem Biol
; 30(5): 457-469.e11, 2023 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37148884
17.
Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome.
Cell Chem Biol
; 30(5): 470-485.e6, 2023 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36963402
18.
Use of tafenoquine to treat a patient with relapsing babesiosis with clinical and molecular evidence of resistance to azithromycin and atovaquone.
IDCases
; 27: e01460, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35242564
19.
Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors.
J Med Chem
; 65(13): 9350-9375, 2022 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35727231
20.
Can repurposing drugs play a role in malaria control?
J Exp Med
; 218(12)2021 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34807244