Detalhe da pesquisa
1.
Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2.
Proc Natl Acad Sci U S A
; 119(9)2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35217606
2.
Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW Macrophages.
Int J Mol Sci
; 24(2)2023 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36675159
3.
LRRK2 protects immune cells against erastin-induced ferroptosis.
Neurobiol Dis
; 175: 105917, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36336242
4.
The multifaceted role of LRRK2 in Parkinson's disease: From human iPSC to organoids.
Neurobiol Dis
; 173: 105837, 2022 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35963526
5.
The beneficial effect of salubrinal on neuroinflammation and neuronal loss in intranigral LPS-induced hemi-Parkinson disease model in rats.
Immunopharmacol Immunotoxicol
; 44(2): 168-177, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35021949
6.
Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies.
Biochem J
; 477(7): 1203-1218, 2020 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32167135
7.
Combined FCS and PCH Analysis to Quantify Protein Dimerization in Living Cells.
Int J Mol Sci
; 22(14)2021 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34298920
8.
The cytoskeleton regulates symmetry transitions in moving amoeboid cells.
J Cell Sci
; 131(7)2018 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29487182
9.
Allosteric inhibition of LRRK2, where are we now.
Biochem Soc Trans
; 48(5): 2185-2194, 2020 10 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33079169
10.
Structure and nucleotide-induced conformational dynamics of the Chlorobium tepidum Roco protein.
Biochem J
; 476(1): 51-66, 2019 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30538153
11.
GPCR-controlled membrane recruitment of negative regulator C2GAP1 locally inhibits Ras signaling for adaptation and long-range chemotaxis.
Proc Natl Acad Sci U S A
; 114(47): E10092-E10101, 2017 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-29109256
12.
Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.
Proc Natl Acad Sci U S A
; 113(30): E4357-66, 2016 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27357661
13.
Roco Proteins: GTPases with a Baroque Structure and Mechanism.
Int J Mol Sci
; 20(1)2019 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30609797
14.
The role of (auto)-phosphorylation in the complex activation mechanism of LRRK2.
Biol Chem
; 399(7): 643-647, 2018 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29537215
15.
Biochemical and kinetic properties of the complex Roco G-protein cycle.
Biol Chem
; 399(12): 1447-1456, 2018 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30067506
16.
Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells.
BMC Cell Biol
; 17: 1, 2016 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26744136
17.
The unconventional G-protein cycle of LRRK2 and Roco proteins.
Biochem Soc Trans
; 44(6): 1611-1616, 2016 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27913669
18.
Revisiting the Roco G-protein cycle.
Biochem J
; 465(1): 139-47, 2015 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25317655
19.
Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis.
Proc Natl Acad Sci U S A
; 110(16): 6424-9, 2013 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23576747
20.
Function and Regulation of Heterotrimeric G Proteins during Chemotaxis.
Int J Mol Sci
; 17(1)2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26784171