Detalhe da pesquisa
1.
CAG repeat expansion in the Huntington's disease gene shapes linear and circular RNAs biogenesis.
PLoS Genet
; 19(10): e1010988, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37831730
2.
Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection.
Nucleic Acids Res
; 49(7): 3907-3918, 2021 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33751106
3.
Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.
Hum Mol Genet
; 29(18): 3044-3053, 2020 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32876667
4.
High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds.
Hum Mol Genet
; 26(5): 913-922, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28334820
5.
Chromosome substitution strain assessment of a Huntington's disease modifier locus.
Mamm Genome
; 26(3-4): 119-30, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25645993
6.
Splice modulators target PMS1 to reduce somatic expansion of the Huntington's disease-associated CAG repeat.
Nat Commun
; 15(1): 3182, 2024 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38609352
7.
Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice.
Elife
; 92020 09 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32990597
8.
HttQ111/+ Huntington's Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction.
J Huntingtons Dis
; 7(1): 17-33, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29480209
9.
The protein-tyrosine phosphatase DEP-1 modulates growth factor-stimulated cell migration and cell-matrix adhesion.
Oncogene
; 22(27): 4175-85, 2003 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-12833140
10.
A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice.
PLoS One
; 8(11): e80923, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24278347
11.
Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice.
PLoS One
; 7(9): e44273, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22970194