1.
Bioorg Med Chem Lett
; 20(24): 7421-5, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21044843
RESUMO
This paper describes the discovery and design of a novel class of JAK2 inhibitors. Furthermore, we detail the optimization of a screening hit using ligand binding efficiency and log D. These efforts led to the identification of compound 41, which demonstrates in vivo activity in our study.