[Congenital and acquired cytomegalovirus infection in infants confirmed by virologic studies]. / Cytomegalia wrodzona i nabyta niemowlat potwierdzona badaniami wirusologicznymi.

Sixty infants in whom clinical symptoms suspected of cytomegalovirus (CMV) infection were studied. CMV infection was found in 50% of the subjects. The diagnosis was based on studies of specific antibodies and isolation of the virus from urine and/or throat swabs. In most of the children the examinations were repeated several times, and clinical observations continued for 1 to 42 months (avg. 18 months). IgM-class antibodies were detected in 26 children and in 18 the virus was isolated. In 3 infants, isolation of CMV virus was the only evidence of active infection. Persisting viruria (avg. 11 months) and long-term presence of Ig G antibodies, even to 44th month of life were also observed. Congenital infection was diagnosed in 4 infants; the remaining ones acquired the infection during the perinatal period or later. In 7 cases transfused blood cannot be excluded as the source of infection. The clinical symptoms manifested in infected and non-infected children were similar. There was a statistically significant increase in the occurrence of hepatomegaly, splenomegaly, hyperbiliru-binemia and diarrhoea in infected children. Congenital abnormalities were found in 10 infected children, including 4 cases of congenital cytomegaly.

The effect of gluten-free diet supplemented with Humana-MCT on the level of lipid fractions in blood serum of infants with coeliac disease.

The concentrations of free fatty acids (FFA), triglycerides (TG), free cholesterol (FC) and estrified cholesterol (EC) as well as the fatty acid composition of TG and EC fractions have been determined in blood serum of 16 infants with coeliac disease. The determinations were carried out three times: after admission and diagnosis but before the initiation of any treatment, after two and after four weeks of a glutene-free diet supplemented with Humana-MCT formula. Before treatment all the infants had weight deficite between 20% and 40%. After two weeks of diet treatment, the concentrations of blood serum FFA and TG decreased as compared to those before the treatment. The highest values of EC were found during the third determination. The composition of fatty acids in TG and EC fractions did not change appreciably in the consecutive determinations. The absence of medium chain-length fatty acids in the studied lipid fractions despite steady supply in the diet suggests efficient metabolization of these acids in the liver. A considerable deficite of linoleic acid appearing in the infants studied before the treatment was not fully compensated during the four weeks of diet treatment.

Clinical manifestation of IgA deficiency.

Thirty patients, 2-12 years of age, with selective IgA deficiency or low level of IgA were investigated. Among them we found 5 children with coeliac disease, 15 with milk protein intolerance. Recurrent respiratory tract infections, otitis, septicemia and urinary tract infections were also frequently noted.