RESUMO
BACKGROUND: Scalp conditions are often multifactorial. OBJECTIVE: To characterize patients with scalp involvement and patch-testing outcomes. METHODS: Retrospective cross-sectional analysis of North American Contact Dermatitis Group data (1996-2016). Study groups included patients with scalp involvement (≤3 anatomic sites coded) with or without additional sites. RESULTS: A total of 4.8% of patients (2331/48,753) had scalp identified as 1 of up to 3 affected anatomic sites. Approximately one-third of "scalp-only" individuals had a specific primary diagnosis of allergic contact dermatitis (38.6%), followed by seborrheic dermatitis (17.2%) and irritant contact dermatitis (9.3%). When adjacent anatomic sites were affected, allergic contact dermatitis was more frequently identified as the primary diagnosis (>50%). The top 5 currently clinically relevant allergens in scalp-only patients were p-phenylenediamine, fragrance mix I, nickel sulfate, balsam of Peru, and cinnamic aldehyde. Methylisothiazolinone sensitivity was notable when adjacent anatomic sites were involved. The top 3 specifically identified sources for scalp-only allergens were hair dyes, shampoo/conditioners, and consumer items (eg, hair appliances, glasses). LIMITATIONS: Tertiary referral population. CONCLUSION: Isolated scalp involvement was less likely to be associated with allergic contact dermatitis than when adjacent anatomic sites were involved. Overlap with multiple diagnoses was frequent, including seborrheic dermatitis, irritant dermatitis, other dermatoses, or all 3. p-Phenylenediamine was the most common allergen.
Assuntos
Dermatite Alérgica de Contato/patologia , Dermatite Irritante/patologia , Testes do Emplastro , Dermatoses do Couro Cabeludo/patologia , Adulto , Idoso , Alérgenos/efeitos adversos , Canadá/epidemiologia , Estudos Transversais , Dermatite Alérgica de Contato/epidemiologia , Dermatite Alérgica de Contato/etiologia , Dermatite Atópica/epidemiologia , Dermatite Atópica/etiologia , Dermatite Atópica/patologia , Dermatite Irritante/epidemiologia , Dermatite Irritante/etiologia , Dermatite Seborreica/epidemiologia , Dermatite Seborreica/etiologia , Dermatite Seborreica/patologia , Óculos , Feminino , Tinturas para Cabelo/efeitos adversos , Preparações para Cabelo/efeitos adversos , Humanos , Irritantes/efeitos adversos , Masculino , Pessoa de Meia-Idade , Especificidade de Órgãos , Estudos Retrospectivos , Dermatoses do Couro Cabeludo/epidemiologia , Dermatoses do Couro Cabeludo/etiologia , Estados Unidos/epidemiologiaRESUMO
We present three African American infants with segmental, ulcerated infantile hemangiomas and concomitant, persistent hypertension. When treated with beta-blocker therapy, the hemangiomas decreased in size and the ulcerations resolved, but there was no impact on the elevated blood pressure in one of our patients. We failed to identify any associations between infantile hemangioma and hypertension in the literature.
Assuntos
Hemangioma Capilar , Hemangioma , Hipertensão , Neoplasias Cutâneas , Negro ou Afro-Americano , Hemangioma/complicações , Hemangioma/diagnóstico , Hemangioma/tratamento farmacológico , Hemangioma Capilar/complicações , Hemangioma Capilar/diagnóstico , Hemangioma Capilar/tratamento farmacológico , Humanos , Hipertensão/complicações , Hipertensão/tratamento farmacológico , Lactente , Recém-Nascido , Neoplasias Cutâneas/complicações , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/tratamento farmacológico , ÚlceraRESUMO
Isothiazolinones, preservatives including methylisothiazolinone (MI), methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), benzisothiazolinone (BIT), and octylisothiazolinone (OIT), are notorious contact allergens. Pediatric dermatologists are familiar with these preservatives in personal care products, homemade slime recipes, and wet wipes. We present a novel source of MI declared in nail polish marketed to children.
Assuntos
Cosméticos , Dermatite Alérgica de Contato , Criança , Cosméticos/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Humanos , Testes do Emplastro , Polônia , Conservantes Farmacêuticos/efeitos adversos , TiazóisRESUMO
Pembrolizumab, a programmed cell death protein 1 (PD1) inhibitor, has been known to be associated with several adverse reactions, including immune related adverse events. In less than one percent of patients, PD1 inhibitors have been linked to the development of connective tissue disease. Patients with previously known connective tissue disease are hypothesized to be at increased risk of flares in as many as 40% of cases. A 70-year-old man with a past medical history significant for rheumatoid arthritis in remission and stage IV lung adenocarcinoma presented to the dermatology clinic after one cycle of nivolumab and eight cycles of pembrolizumab exhibiting worsening, painful bilateral lower extremity ulcers for approximately one month. On the lower legs, three large black retiform eschars and bullous purpuric plaques were observed. Vasculitis is a rare complication of PD1 inhibitor therapy, with the majority of cases reported in literature either medium vessel or large vessel vasculitis. Only glucocorticoids have proven effective for PD1-induced vasculitis and these patients generally require multi-specialty management.
Assuntos
Adenocarcinoma de Pulmão/tratamento farmacológico , Anticorpos Monoclonais Humanizados/efeitos adversos , Inibidores de Checkpoint Imunológico/efeitos adversos , Úlcera da Perna/induzido quimicamente , Neoplasias Pulmonares/tratamento farmacológico , Vasculite Reumatoide/induzido quimicamente , Adenocarcinoma de Pulmão/complicações , Adenocarcinoma de Pulmão/secundário , Idoso , Artrite Reumatoide/complicações , Desprescrições , Glucocorticoides/uso terapêutico , Insuficiência Cardíaca/induzido quimicamente , Humanos , Úlcera da Perna/tratamento farmacológico , Úlcera da Perna/patologia , Doenças Pulmonares Intersticiais/induzido quimicamente , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/patologia , Masculino , Nivolumabe/efeitos adversos , Vasculite Reumatoide/tratamento farmacológico , Vasculite Reumatoide/patologiaAssuntos
Dermatite Alérgica de Contato/epidemiologia , Dermatite Ocupacional/epidemiologia , Tinturas para Cabelo/efeitos adversos , Testes do Emplastro/métodos , Fenilenodiaminas/imunologia , Adulto , Fatores Etários , Comorbidade , Estudos Transversais , Dermatite Alérgica de Contato/diagnóstico , Dermatite Alérgica de Contato/imunologia , Dermatite Irritante/epidemiologia , Dermatite Ocupacional/diagnóstico , Dermatite Ocupacional/imunologia , Feminino , Seguimentos , Tinturas para Cabelo/química , Humanos , Masculino , Pessoa de Meia-Idade , América do Norte/epidemiologia , Fenilenodiaminas/administração & dosagem , Estudos Retrospectivos , Fatores SexuaisAssuntos
Dermatite Alérgica de Contato/etiologia , Produtos de Higiene Feminina/efeitos adversos , Doenças dos Genitais Femininos/induzido quimicamente , Triazóis/efeitos adversos , Dermatite Alérgica de Contato/diagnóstico , Feminino , Doenças dos Genitais Femininos/diagnóstico , Humanos , Pessoa de Meia-Idade , Testes do Emplastro , Incontinência Urinária por Estresse/terapiaRESUMO
Background: Chlorhexidine is an antiseptic that may cause allergic contact dermatitis. Objectives: To describe the epidemiology of chlorhexidine allergy and characterize positive patch test reactions. Methods: This retrospective study analyzed patients patch tested to chlorhexidine digluconate 1% aqueous by the North American Contact Dermatitis Group, 2015-2020. Results: Of 14,731 patients tested to chlorhexidine digluconate, 107 (0.7%) had an allergic reaction; of these, 56 (52.3%) reactions were currently clinically relevant. Most (59%) reactions were mild (+), followed by strong (++, 18.7%) and very strong (+++, 6.5%). Common primary dermatitis anatomic sites in chlorhexidine-positive patients were hands (26.4%), face (24.5%), and scattered/generalized distribution (17.9%). Compared with negative patients, chlorhexidine-positive patients were significantly more likely to have dermatitis involving the trunk (11.3% vs 5.1%; P = 0.0036). The most commonly identified source category was skin/health care products (n = 41, 38.3%). Only 11 (10.3%) chlorhexidine reactions were occupationally related; of these, 81.8% were in health care workers. Conclusions: Chlorhexidine digluconate allergy is uncommon, but often clinically relevant. Involvement of the hands, face, and scattered generalized patterns was frequent. Occupationally related reactions were found predominantly in health care workers.
Assuntos
Dermatite Alérgica de Contato , Dermatite Ocupacional , Humanos , Clorexidina/efeitos adversos , Dermatite Ocupacional/diagnóstico , Dermatite Ocupacional/epidemiologia , Dermatite Ocupacional/etiologia , Testes do Emplastro/efeitos adversos , Estudos Retrospectivos , Dermatite Alérgica de Contato/diagnóstico , Dermatite Alérgica de Contato/epidemiologia , Dermatite Alérgica de Contato/etiologia , América do Norte/epidemiologia , AlérgenosRESUMO
Plantar dermatoses (PD) are common, occurring either spontaneously on healthy skin or developing secondarily from previously established foot disease. PD share similar symptoms and morphology, making them challenging to differentiate. A few of the most frequently encountered PD include tinea pedis, psoriasis, contact dermatitis, dyshidrotic dermatitis (or recurrent vesicular palmoplantar dermatitis), and juvenile plantar dermatosis. This review offers practical advice for diagnosing and treating the most common PD in the primary care office.
Assuntos
Tinha dos Pés , Humanos , Tinha dos Pés/diagnóstico , Tinha dos Pés/terapiaRESUMO
IMPORTANCE: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is known to cause multiple end-organ complications in its acute phase, but less is known about the long-term association with patients' mental health and quality of life. OBJECTIVE: To examine the chronic physical and psychological sequelae affecting patients with SJS/TEN. DESIGN, SETTING, AND PARTICIPANTS: A survey study conducted at 11 academic health centers in the US evaluated 121 adults diagnosed with SJS/TEN by inpatient consultive dermatologists between January 1, 2009, and September 30, 2019. INTERVENTIONS: Patients completed a survey that included the following validated questionnaires: Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), Primary Care Post-Traumatic Stress Disorder Screen (PC-PTSD), and the 12-item Short Form Health Survey (SF-12). The survey also included questions created by the study team regarding fear, patient education, and long-term sequelae relevant to SJS/TEN. MAIN OUTCOMES AND MEASURES: Primary outcome measures were the percentage of patients reporting long-term physical sequelae; the percentage of patients with positive results on PHQ-9, GAD-7, and PC-PTSD screening; and the numeric score on the SF-12 (score of 50 defined as average physical and mental well-being). RESULTS: A total of 121 individuals (73 women [60.3%]; mean [SD] age, 52.5 [17.1] years) completed the survey (response rate, 29.2%). The most common long-term physical sequelae reported were cutaneous problems (102 of 121 [84.3%]), ocular problems (72 of 121 [59.5%]), and oral mucosal problems (61 of 120 [50.8%]). A total of 53.3% (64 of 120) of the respondents had results indicating depression on the PHQ-9, 43.3% (52 of 120) showed signs of anxiety on the GAD-7, and 19.5% had results indicating PTSD on the PC-PTSD. The mean (SD) SF-12 Physical Component Summary score was 42.4 (22.8), and the mean Mental Component Summary score was 46.1 (20.9). A total of 28.2% (33 of 117) of the respondents were unable to work, 68.1% (81 of 119) were fearful of taking new medications, and 30.0% (36 of 120) avoided taking prescribed medications for a diagnosed medical condition. CONCLUSIONS AND RELEVANCE: This survey study found that long-term physical sequelae, depression, and anxiety appear to be common in patients with SJS/TEN, with implications for health and well-being. Improved awareness of these complications may assist health professionals in offering medical care, counseling, and support to patients with SJS/TEN.
Assuntos
Síndrome de Stevens-Johnson , Adulto , Feminino , Humanos , Pessoa de Meia-Idade , Mucosa Bucal , Exame Físico/métodos , Qualidade de Vida , Estudos Retrospectivos , Síndrome de Stevens-Johnson/tratamento farmacológicoRESUMO
BACKGROUND: Contact dermatitis can be difficult to manage and overwhelming for patients, often requiring significant lifestyle changes. OBJECTIVE: The aim of the study was to investigate whether a contact dermatitis support group could help patients find community and learn from others who share similar experiences. METHODS: Hour-long, monthly support group meetings facilitated by a social worker, research fellows, and a faculty dermatologist were held for approximately 1.5 years. A 32-question, cross-sectional survey was administered to assess perception of contact dermatitis and overall usefulness of the group. RESULTS: Between 2 and 5 patients attended each group session; 9 participants completed the survey. Most were female (77.8%) and white (77.8%), with an average age of 68.8 years. Eight participants (88.9%) reported that it was important or somewhat important to socialize with others affected by contact dermatitis. Three group members (33.3%) had met with attendees outside of the monthly sessions. The majority (77.8%) reported that the support group had a positive effect on their understanding of contact dermatitis and would recommend the group to others (88.9%). CONCLUSIONS: Support groups may be helpful for patients learning to cope with the challenges associated with contact dermatitis. Although preliminary feedback is promising, further investigation is warranted to determine whether these groups are effective on a larger scale.
Assuntos
Dermatite Alérgica de Contato/fisiopatologia , Dermatite Irritante/fisiopatologia , Qualidade de Vida , Grupos de Autoajuda , Idoso , Dermatite Alérgica de Contato/psicologia , Dermatite Irritante/psicologia , Feminino , Humanos , Masculino , Projetos Piloto , Inquéritos e QuestionáriosRESUMO
: Cutaneous exposure to aluminum may occur via contact with metal items, medications, and personal care products. Despite the widespread use of aluminum, allergic contact dermatitis is relatively rare. Sensitization is often incidentally identified during patch testing with aluminum-based chambers. This article presents several cases along with a literature review summarizing prevalence and clinical manifestations of cutaneous reactions to aluminum, recommendations for patch testing, sources of aluminum, and reproducibility of aluminum allergy over time.
Assuntos
Alumínio/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Antiácidos/química , Antiperspirantes/química , Dessensibilização Imunológica , Humanos , Tatuagem , Cremes Dentais/química , Vacinas/químicaRESUMO
This case report describes a man in his 50s with HIV/AIDS who presented with widely scattered recalcitrant mpox lesions.