Detalhe da pesquisa
1.
A reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease.
J Autoimmun
; 144: 103181, 2024 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38522129
2.
A combined approach of structure-based virtual screening and NMR to interrupt the PD-1/PD-L1 axis: Biphenyl-benzimidazole containing compounds as novel PD-L1 inhibitors.
Arch Pharm (Weinheim)
; 357(3): e2300583, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38110703
3.
Enriching the Arsenal of Pharmacological Tools against MICAL2.
Molecules
; 26(24)2021 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34946600
4.
Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation.
Bioorg Med Chem
; 23(21): 7053-60, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26432608
5.
Receptor-bound conformation of cilengitide better represented by its solution-state structure than the solid-state structure.
Chemistry
; 20(44): 14201-6, 2014 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25251673
6.
Development and Nanoparticle-Mediated Delivery of Novel MDM2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in Colorectal Cancer Cells.
J Med Chem
; 67(3): 1812-1824, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38285632
7.
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies.
Bioorg Med Chem Lett
; 23(1): 85-9, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23218605
8.
Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design.
Comput Struct Biotechnol J
; 21: 3355-3368, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37384351
9.
HuR modulation counteracts lipopolysaccharide response in murine macrophages.
Dis Model Mech
; 16(3)2023 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36912171
10.
Protein flexibility in virtual screening: the BACE-1 case study.
J Chem Inf Model
; 52(10): 2697-704, 2012 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23005250
11.
Identification of a Novel p53 Modulator Endowed with Antitumoural and Antibacterial Activity through a Scaffold Repurposing Approach.
Pharmaceuticals (Basel)
; 15(11)2022 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36355491
12.
HuR-targeted agents: An insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models.
Adv Drug Deliv Rev
; 181: 114088, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34942276
13.
CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme.
Eur J Pharmacol
; 897: 173936, 2021 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33581134
14.
Interfering with the Tumor-Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors.
J Med Chem
; 64(21): 16020-16045, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34670084
15.
Design, synthesis and biological evaluation of novel TRß selective agonists sustained by ADME-toxicity analysis.
Eur J Med Chem
; 188: 112006, 2020 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31931337
16.
Long lasting inhibition of Mdm2-p53 interaction potentiates mesenchymal stem cell differentiation into osteoblasts.
Biochim Biophys Acta Mol Cell Res
; 1866(5): 737-749, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30703414
17.
Benzothiopyranoindole- and pyridothiopyranoindole-based antiproliferative agents targeting topoisomerases.
Eur J Med Chem
; 165: 46-58, 2019 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30660826
18.
Correction to "Discovery of the First-in-Class GSK-3ß/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease".
ACS Med Chem Lett
; 10(9): 1357, 2019 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31531210
19.
Discovery of the First-in-Class GSK-3ß/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease.
ACS Med Chem Lett
; 10(4): 469-474, 2019 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30996781
20.
Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells.
ACS Chem Neurosci
; 9(1): 85-99, 2018 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28368610