Detalhe da pesquisa
1.
SMaSh: A Streptavidin Mass Shift Assay for Rapidly Quantifying Target Occupancy by Irreversible Inhibitors.
Biochemistry
; 60(39): 2915-2924, 2021 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34554726
2.
Labeling Preferences of Diazirines with Protein Biomolecules.
J Am Chem Soc
; 143(17): 6691-6700, 2021 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33876925
3.
S-adenosyl-l-methionine protection of acetaminophen mediated oxidative stress and identification of hepatic 4-hydroxynonenal protein adducts by mass spectrometry.
Toxicol Appl Pharmacol
; 281(2): 174-84, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25246065
4.
Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans.
J Pharmacol Exp Ther
; 346(2): 219-28, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23709115
5.
Metabolites of PPI-2458, a selective, irreversible inhibitor of methionine aminopeptidase-2: structure determination and in vivo activity.
Drug Metab Dispos
; 41(4): 814-26, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23355637
6.
Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine.
Nat Chem Biol
; 7(1): 22-4, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21113170
7.
Protein electrophile-binding motifs: lysine-rich proteins are preferential targets of quinones.
Drug Metab Dispos
; 37(6): 1211-8, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19251821
8.
A novel methionine aminopeptidase-2 inhibitor, PPI-2458, inhibits non-Hodgkin's lymphoma cell proliferation in vitro and in vivo.
Clin Cancer Res
; 12(8): 2583-90, 2006 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16638869
9.
Inhibition of melanoma tumor growth by a pharmacological inhibitor of MetAP-2, PPI-2458.
Int J Oncol
; 28(4): 955-63, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16525646
10.
In vitro and in vivo characterization of irreversible mutant-selective EGFR inhibitors that are wild-type sparing.
Mol Cancer Ther
; 13(6): 1468-79, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24723450
11.
Orally active fumagillin analogues: transformations of a reactive warhead in the gastric environment.
ACS Med Chem Lett
; 4(4): 381-6, 2013 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900682
12.
Utilization of MALDI-TOF to determine chemical-protein adduct formation in vitro.
Methods Mol Biol
; 691: 303-16, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-20972761
13.
Utilization of LC-MS/MS analyses to identify site-specific chemical protein adducts in vitro.
Methods Mol Biol
; 691: 317-26, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-20972762
14.
One-dimensional western blotting coupled to LC-MS/MS analysis to identify chemical-adducted proteins in rat urine.
Methods Mol Biol
; 691: 327-38, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-20972763
15.
Identification of chemical-adducted proteins in urine by multi-dimensional protein identification technology (LC/LC-MS/MS).
Methods Mol Biol
; 691: 339-47, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-20972764
16.
The frequency of 1,4-benzoquinone-lysine adducts in cytochrome c correlate with defects in apoptosome activation.
Toxicol Sci
; 122(1): 64-72, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21527774
17.
Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2.
J Med Chem
; 52(24): 8047-56, 2009 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19929003
18.
Quinone electrophiles selectively adduct "electrophile binding motifs" within cytochrome c.
Biochemistry
; 46(39): 11090-100, 2007 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17824617
19.
A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis.
Proc Natl Acad Sci U S A
; 101(29): 10768-73, 2004 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15249666