Detalhe da pesquisa
1.
The spliceosome is a therapeutic vulnerability in MYC-driven cancer.
Nature
; 525(7569): 384-8, 2015 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26331541
2.
A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore.
Bioorg Med Chem Lett
; 27(3): 406-412, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28049589
3.
Sudemycin E influences alternative splicing and changes chromatin modifications.
Nucleic Acids Res
; 42(8): 4947-61, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24623796
4.
Dissecting paclitaxel-microtubule association: quantitative assessment of the 2'-OH group.
Biochemistry
; 52(13): 2328-36, 2013 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23473345
5.
Erratum to "A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore" [Bioorg. Med. Chem. Lett. 27 (2017) 406-412].
Bioorg Med Chem Lett
; 27(6): 1488-1489, 2017 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28214076
6.
An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications.
PLoS One
; 15(5): e0233672, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32469945
7.
Specificity of the N-benzoyl transferase responsible for the last step of Taxol biosynthesis.
Arch Biochem Biophys
; 477(2): 384-9, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18621016
8.
Splicing Factor 3B Subunit 1 Interacts with HIV Tat and Plays a Role in Viral Transcription and Reactivation from Latency.
mBio
; 9(6)2018 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30401776
9.
Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease.
Sci Rep
; 7(1): 17139, 2017 12 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29215062
10.
Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.
Nat Commun
; 8: 14060, 2017 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28067246
11.
Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates.
Pharmacol Res Perspect
; 3(4): e00158, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26171237
12.
The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia.
Oncotarget
; 6(26): 22734-49, 2015 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26068951
13.
Pre-mRNA splicing-modulatory pharmacophores: the total synthesis of herboxidiene, a pladienolide-herboxidiene hybrid analog and related derivatives.
ACS Chem Biol
; 9(3): 643-8, 2014 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24377313
14.
Optimization of antitumor modulators of pre-mRNA splicing.
J Med Chem
; 56(24): 10033-44, 2013 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24325474
15.
Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing.
ACS Chem Biol
; 6(6): 582-9, 2011 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-21344922
16.
Radiosynthesis of antitumor spliceosome modulators.
Appl Radiat Isot
; 69(9): 1231-4, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21531567
17.
Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.
J Med Chem
; 52(22): 6979-90, 2009 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19877647
18.
Antitumor compounds based on a natural product consensus pharmacophore.
J Med Chem
; 51(19): 6220-4, 2008 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-18788726
19.
The dioxanone approach to (2S,3R)-2-C-methylerythritol 4-phosphate and 2,4-cyclodiphosphate, and various MEP analogues.
J Org Chem
; 72(26): 9886-95, 2007 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-18020362