Recovered grasping performance after stroke depends on interhemispheric frontoparietal connectivity.

Activity changes in the ipsi- and contralesional parietal cortex and abnormal interhemispheric connectivity between these regions are commonly observed after stroke, however, their significance for motor recovery remains poorly understood. We here assessed the contribution of ipsilesional and contralesional anterior intraparietal cortex (aIPS) for hand motor function in 18 recovered chronic stroke patients and 18 healthy control subjects using a multimodal assessment consisting of resting-state functional MRI, motor task functional MRI, online-repetitive transcranial magnetic stimulation (rTMS) interference, and 3D movement kinematics. Effects were compared against two control stimulation sites, i.e. contralesional M1 and a sham stimulation condition. We found that patients with good motor outcome compared to patients with more substantial residual deficits featured increased resting-state connectivity between ipsilesional aIPS and contralesional aIPS as well as between ipsilesional aIPS and dorsal premotor cortex. Moreover, interhemispheric connectivity between ipsilesional M1 and contralesional M1 as well as ipsilesional aIPS and contralesional M1 correlated with better motor performance across tasks. TMS interference at individual aIPS and M1 coordinates led to differential effects depending on the motor task that was tested, i.e. index finger-tapping, rapid pointing movements, or a reach-grasp-lift task. Interfering with contralesional aIPS deteriorated the accuracy of grasping, especially in patients featuring higher connectivity between ipsi- and contralesional aIPS. In contrast, interference with the contralesional M1 led to impaired grasping speed in patients featuring higher connectivity between bilateral M1. These findings suggest differential roles of contralesional M1 and aIPS for distinct aspects of recovered hand motor function, depending on the reorganization of interhemispheric connectivity.

Massive Vector Form Factors to Three Loops.

We compute the three-loop nonsinglet corrections to the photon-quark form factors taking into account the full dependence on the virtuality of the photon and the quark mass. We combine the method of differential equations in an effective way with expansions around regular and singular points. This allows us to obtain results for the form factors with an accuracy of about eight to twelve digits in the whole kinematic range.

Labor demand in the time of COVID-19: Evidence from vacancy postings and UI claims.

We use job vacancy data collected in real time by Burning Glass Technologies, as well as unemployment insurance (UI) initial claims and the more traditional Bureau of Labor Statistics (BLS) employment data to study the impact of COVID-19 on the labor market. Our job vacancy data allow us to track the economy at disaggregated geography and by detailed occupation and industry. We find that job vacancies collapsed in the second half of March. By late April, they had fallen by over 40%. To a first approximation, this collapse was broad based, hitting all U.S. states, regardless of the timing of stay-at-home policies. UI claims and BLS employment data also largely match these patterns. Nearly all industries and occupations saw contraction in postings and spikes in UI claims, with little difference depending on whether they are deemed essential and whether they have work-from-home capability. Essential retail, the "front line" job most in-demand during the current crisis, took a much smaller hit, while leisure and hospitality services and non-essential retail saw the biggest collapses. This set of facts suggests the economic collapse was not caused solely by the stay-at-home orders, and is therefore unlikely to be undone simply by lifting them.

Waiting for Recovery: The Canadian Labour Market in June 2020.

The Canadian labour market is currently emerging from a holding pattern with unusually high numbers of people in temporary (or "recall") unemployment, people who are "employed but absent from work" for unspecified reasons, or people who are not in the labour force while waiting to be recalled. Two encouraging signs are evident. New postings of vacancies have recovered from 50 percent to about 80 percent of their pre-crisis level. Also, data suggest that the increase in employment in May 2020 is due to the re-entry into employment of some of those waiting to be recalled. These patterns suggest that the labour market might rebound quickly. Warning signs are that the shares of unemployed persons without job attachment and of those on recall engaged in job search are beginning to increase.

Le marché du travail canadien émerge actuellement d'un scénario persistant de surcroît anormal de travailleurs en chômage temporaire (ou licenciés en rappel), ceux qui sont « employés mais absents du travail ¼ pour des raisons qui ne sont pas précisées ou ceux qui, dans l'attente d'un rappel, ne font pas partie de la population active. Deux signes encourageants apparaissent évidents. Les nouveaux affichages de postes à pourvoir se sont redressés, passant de 50 pour cent à environ 80 pour cent de leur niveau antérieur à la crise, et les données semblent en outre indiquer que la hausse de l'emploi en mai 2020 est attribuable au retour au travail de certains des travailleurs en attente de rappel. Ces éléments d'information laissent supposer que le marché du travail pourrait se rétablir rapidement. Les signaux d'alerte sont les suivants : les proportions de personnes au chômage qui n'ont pas de lien d'emploi et des personnes en attente de rappel qui sont à la recherche d'un emploi sont à la hausse.

Testing for changes in the SES-mortality gradient when the distribution of education changes too.

We develop a flexible test for changes in the SES-mortality gradient that accounts for changes in the distribution of education, the most commonly used marker of SES. We implement the test for the period between 1984 and 2006 in the United States using microdata from the Census and other surveys linked to death records. Using our flexible test, we find that the evidence for a change in the SES-mortality gradient is not as strong as previous research has suggested. Our results indicate that the gradient increased for females during this time period, but we cannot rule out that the gradient among males has not changed. Informally, the results suggest that the changes for females are mainly driven by the bottom of the education distribution.

The role of education in complex health decisions: evidence from cancer screening.

This paper uses data on real and perceived cancer risks and cancer screening behavior to test the allocative efficiency theory. Specifically, it explores whether the educated make better-informed health decisions. I propose that (1) when educated individuals are better informed, they are more likely to incorporate variation in risk factors when they report their personal cancer risk, and (2) as risk varies, the better educated will react more strongly by adopting preventive behaviors such as cancer screening. The results support for both predictions. Further, using data on attitudes toward breast health, I explore a possible mechanism: educated women are more receptive to scientific evidence and hold fewer nonscientific beliefs.

Rising educational gradients in mortality: the role of behavioral risk factors.

The long-standing inverse relationship between education and mortality strengthened substantially at the end of the 20th century. This paper examines the reasons for this increase. We show that behavioral risk factors are not of primary importance. Smoking declined more for the better educated, but not enough to explain the trend. Obesity rose at similar rates across education groups, and control of blood pressure and cholesterol increased fairly uniformly as well. Rather, our results show that the mortality returns to risk factors, and conditional on risk factors, the return to education, have grown over time.

Chronic Disease Burden and the Interaction of Education, Fertility, and Growth.

This study considers the eradication of hookworm disease from the American South as a test of the quantity-quality (Q-Q) framework of fertility. Eradication was principally a shock to the price of quality because of three factors: hookworm (i) depresses the return to human-capital investment, (ii) had a very low case-fatality rate, and (iii) had negligible prevalence among adults. Consistent with the Q-Q model, we find a significant decline in fertility associated with eradication. Relative sizes of fertility and human-capital responses to hookworm indicate that the Q-Q mechanism is of a similar magnitude to secular co-movements in these same variables.