Detalhe da pesquisa
1.
Novel hydrazone compounds with broad-spectrum antiplasmodial activity and synergistic interactions with antimalarial drugs.
Antimicrob Agents Chemother
; : e0164323, 2024 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38639491
2.
Updating the modified Thompson test by using whole-body bioluminescence imaging to replace traditional efficacy testing in experimental models of murine malaria.
Malar J
; 18(1): 38, 2019 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30767768
3.
Use of Optical Imaging Technology in the Validation of a New, Rapid, Cost-Effective Drug Screen as Part of a Tiered In Vivo Screening Paradigm for Development of Drugs To Treat Cutaneous Leishmaniasis.
Antimicrob Agents Chemother
; 61(4)2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28137819
4.
Assessment of the Worldwide Antimalarial Resistance Network Standardized Procedure for In Vitro Malaria Drug Sensitivity Testing Using SYBR Green Assay for Field Samples with Various Initial Parasitemia Levels.
Antimicrob Agents Chemother
; 60(4): 2417-24, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26856829
5.
Discovery and Optimization of Tambjamines as a Novel Class of Antileishmanial Agents.
J Med Chem
; 67(10): 8323-8345, 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38722757
6.
From a cytotoxic agent to the discovery of a novel antimalarial agent.
Bioorg Med Chem Lett
; 23(2): 584-7, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23228469
7.
Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides.
Bioorg Med Chem Lett
; 23(12): 3551-5, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23664871
8.
Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase.
Bioorg Med Chem Lett
; 23(7): 2035-43, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23453069
9.
3,5-bis(benzylidene)-4-piperidones and related N-acyl analogs: a novel cluster of antimalarials targeting the liver stage of Plasmodium falciparum.
Bioorg Med Chem
; 21(23): 7250-6, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24139941
10.
Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway.
Antimicrob Agents Chemother
; 56(5): 2666-82, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22354304
11.
Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy.
Eur J Drug Metab Pharmacokinet
; 37(1): 17-22, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22314893
12.
Use of the NP-40 detergent-mediated assay in discovery of inhibitors of beta-hematin crystallization.
Antimicrob Agents Chemother
; 55(7): 3363-9, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21518844
13.
Characterization of in vivo metabolites of WR319691, a novel compound with activity against Plasmodium falciparum.
Eur J Drug Metab Pharmacokinet
; 36(3): 151-8, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21751074
14.
Combination of Subtherapeutic Doses of Tretazicar and Liposomal Amphotericin B Suppresses and Cures Leishmania major-Induced Cutaneous Lesions in Murine Models.
ACS Infect Dis
; 7(2): 506-517, 2021 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33529014
15.
In Vivo Bioluminescent Monitoring of Parasites in BALB/c Mouse Models of Cutaneous Leishmaniasis Drug Discovery.
Methods Mol Biol
; 2081: 81-106, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31721120
16.
Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors.
ACS Med Chem Lett
; 11(3): 249-257, 2020 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184953
17.
Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.
J Med Chem
; 63(11): 6179-6202, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32390431
18.
Novel benzoxaborole, nitroimidazole and aminopyrazoles with activity against experimental cutaneous leishmaniasis.
Int J Parasitol Drugs Drug Resist
; 11: 129-138, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30922847
19.
Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.
J Med Chem
; 62(7): 3475-3502, 2019 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30852885
20.
Optimization of Physicochemical Properties for 4-Anilinoquinoline Inhibitors of Plasmodium falciparum Proliferation.
ACS Infect Dis
; 4(4): 577-591, 2018 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29301082