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Identifying distinct neural networks underlying social affect (empathy, compassion) and social cognition (Theory of Mind) has advanced our understanding of social interactions. However, little is known about the relation of activation in these networks to psychological experience in daily life. This study (N = 122) examined the ecological validity of neural activation patterns induced by a laboratory paradigm of social affect and cognition with respect to social interactions in everyday life. We used the EmpaToM task, a naturalistic video-based paradigm for the assessment of empathy, compassion, and Theory of Mind, and combined it with a subsequent 14-day ecological momentary assessment protocol on social interactions. Everyday social affect was predicted by social affect experienced during the EmpaToM task, but not by related neural activation in regions of interest from the social affect network. In contrast, everyday social cognition was predicted by neural activation differences in the medial prefrontal cortex - a region of interest from the social cognition network - but not by social cognition performance in the EmpaToM task. The relationship between medial prefrontal cortex activation and everyday social cognition was stronger for spontaneous rather than deliberate perspective taking during the EmpaToM task, pointing to a distinction between propensity and capacity in social cognition. Finally, this neural indicator of Theory of Mind explained variance in everyday social cognition to a similar extent as an established self-report scale. Taken together, this study provides evidence for the ecological validity of lab-based social affect and cognition paradigms when considering relevant moderating factors.
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Encéfalo/diagnóstico por imagem , Comportamento Social , Cognição Social , Teoria da Mente/fisiologia , Adolescente , Adulto , Avaliação Momentânea Ecológica , Empatia/fisiologia , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Adulto JovemRESUMO
It is well established that the congenital lack of one sensory modality enhances functionality in the spared senses. However, whether a late onset deprivation of one sense leads to such alterations is largely unknown. Here, we investigated whether a somatosensory deprivation induced by bilateral whisker removal affects visual acuity and contrast sensitivity in fully adult mice. Using the visual cortex-dependent visual water task, we found that a brief somatosensory deprivation markedly improved behavioral visual acuity and contrast sensitivity by about 40%. Determining these attributes of vision using periodic optical imaging of intrinsic signals in the same mice revealed that visual cortex responses elicited by weak visual stimuli were massively increased after somatosensory deprivation. Strikingly, comparison of visual acuity and contrast sensitivity values determined by the visual water task and intrinsic signal imaging revealed that these measurements were almost identical, even at the level of individual animals. In summary, our results suggest that a brief manipulation of somatosensory experience profoundly boosts visual cortex-dependent vision in adults.
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Sensibilidades de Contraste , Privação Sensorial , Vibrissas/fisiologia , Acuidade Visual , Animais , Potenciais Evocados Visuais , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Córtex Visual/fisiologiaRESUMO
Does cortical plasticity depend on the temporal coherence of visual stimuli? We addressed this question by studying ocular dominance (OD) plasticity in mice that were stimulated by moving square wave gratings for 6 h/d during a period of monocular deprivation (MD). It turned out that 4 d of deprivation were sufficient to induce a saturated shift in plasticity in adult (older than postnatal day 100) mice. Seeking to determine the shortest effective period of stimulation, we further showed that even 2 d of deprivation and stimulation shifted OD at any age. This shift was achieved by a decline in deprived-eye input that was saturated within 2 d and did not change during 7 d of MD. However, after 2 weeks of MD, cortical activity induced by both eyes increased again and this increase did not depend on continued stimulation, suggesting a homeostatic mechanism. Starting stimulation 4 d before MD did not mask OD plasticity, showing that the effect is not merely due to the "stimulus-dependent response potentiation" described recently (Frenkel et al., 2006). These results are the first to demonstrate the influence of stimulus quality on cortical plasticity and that cortical responses can be changed within very short periods of time (merely 2 d).
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Dominância Ocular/fisiologia , Plasticidade Neuronal/fisiologia , Privação Sensorial/fisiologia , Visão Monocular/fisiologia , Córtex Visual/fisiologia , Animais , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Neurônios/fisiologia , Estimulação LuminosaRESUMO
Environmental factors have long been known to regulate brain plasticity. We investigated the potential influence of social experience on ocular dominance plasticity. Fully adult female or male mice were monocularly deprived for four days and kept a) either alone or in pairs of the same sex and b) either in a small cage or a large, featureless arena. While mice kept alone did not show ocular dominance plasticity, no matter whether in a cage or in an arena, paired female mice in both environmental conditions displayed a shift of ocular dominance towards the open eye. Paired male mice, in contrast, showed no plasticity in the cage, but a very strong ocular dominance shift in the arena. This effect was not due to increased locomotion, since the covered distance was similar in single and paired male mice in the arena, and furnishing cages with a running wheel did not enable ocular dominance plasticity in cage-housed mice. Confirming recent results in rats, the plasticity-enhancing effect of the social environment was shown to be mediated by serotonin. Our results demonstrate that social experience has a strong effect on cortical plasticity that is sex-dependent. This has potential consequences both for animal research and for human education and rehabilitation.
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Dominância Ocular/fisiologia , Plasticidade Neuronal/fisiologia , Meio Social , Córtex Visual/fisiologia , Envelhecimento , Animais , Feminino , Masculino , Camundongos , Camundongos Endogâmicos C57BLRESUMO
"Lack of empathy" is a diagnostic criterion of narcissism, but the nature of interpersonal functioning in narcissism is still being debated. Both, empathy and narcissism, are multidimensional constructs, and their relation might depend upon contextual factors. We investigated social affect and cognition in narcissism spanning self-reported traits and experiential states (Ecological Momentary Assessment) as well as behavioral and brain indicators (task-related functional magnetic resonance imaging). N = 140 individuals were selected to cover the full dimensional range of grandiose and vulnerable narcissism, including their constituent self-regulatory dimensions of agentic, antagonistic, and neurotic narcissism. Grandiose narcissism was associated with lower social affect at almost all analysis levels. The associations can be attributed to antagonistic self-regulatory dynamics, and are associated with lower brain activation during subjective experiencing of social affect in regions of the salience network. Social cognition was habitually lowered but not impaired in antagonistic narcissism. Our findings do not support a general "lack of empathy." (PsycInfo Database Record (c) 2024 APA, all rights reserved).
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Cognição , Narcisismo , Humanos , Autorrelato , Empatia , Encéfalo/diagnóstico por imagemRESUMO
Social neuroscience has often been criticized for approaching the investigation of the neural processes that enable social interaction and cognition from a passive, detached, third-person perspective, without involving any real-time social interaction. With the emergence of second-person neuroscience, investigators have uncovered the unique complexity of neural-activation patterns in actual, real-time interaction. Social cognition that occurs during social interaction is fundamentally different from that unfolding during social observation. However, it remains unclear how the neural correlates of social interaction are to be interpreted. Here, we leverage the active-inference framework to shed light on the mechanisms at play during social interaction in second-person neuroscience studies. Specifically, we show how counterfactually rich mutual predictions, real-time bodily adaptation, and policy selection explain activation in components of the default mode, salience, and frontoparietal networks of the brain, as well as in the basal ganglia. We further argue that these processes constitute the crucial neural processes that underwrite bona fide social interaction. By placing the experimental approach of second-person neuroscience on the theoretical foundation of the active-inference framework, we inform the field of social neuroscience about the mechanisms of real-life interactions. We thereby contribute to the theoretical foundations of empirical second-person neuroscience.
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Periodontitis, the leading cause of adult tooth loss, has been identified as an independent risk factor for cardiovascular disease (CVD). Studies suggest that periodontitis, like other CVD risk factors, shows the persistence of increased CVD risk even after mitigation. We hypothesized that periodontitis induces epigenetic changes in hematopoietic stem cells in the bone marrow (BM), and such changes persist after the clinical elimination of the disease and underlie the increased CVD risk. We used a BM transplant approach to simulate the clinical elimination of periodontitis and the persistence of the hypothesized epigenetic reprogramming. Using the low-density lipoprotein receptor knockout (LDLRo ) atherosclerosis mouse model, BM donor mice were fed a high-fat diet to induce atherosclerosis and orally inoculated with Porphyromonas gingivalis (Pg), a keystone periodontal pathogen; the second group was sham-inoculated. Naïve LDLR o mice were irradiated and transplanted with BM from one of the two donor groups. Recipients of BM from Pg-inoculated donors developed significantly more atherosclerosis, accompanied by cytokine/chemokines that suggested BM progenitor cell mobilization and were associated with atherosclerosis and/or PD. Using whole-genome bisulfite sequencing, 375 differentially methylated regions (DMRs) and global hypomethylation in recipients of BM from Pg-inoculated donors were observed. Some DMRs pointed to the involvement of enzymes with major roles in DNA methylation and demethylation. In validation assays, we found a significant increase in the activity of ten-eleven translocase-2 and a decrease in the activity of DNA methyltransferases. Plasma S-adenosylhomocysteine levels were significantly higher, and the S-adenosylmethionine to S-adenosylhomocysteine ratio was decreased, both of which have been associated with CVD. These changes may be related to increased oxidative stress as a result of Pg infection. These data suggest a novel and paradigm-shifting mechanism in the long-term association between periodontitis and atherosclerotic CVD.
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By combining behavioural analyses with intrinsic signal optical imaging, we analysed visual performance and visual cortical activity in the albino mouse strain BALB/c, which is increasingly being used as an animal model of neuropsychological disorders. Visual acuity, as measured by a virtual-reality optomotor system, was 0.12 cycles per degree (cyc/deg) in BALB/c mice and 0.39 cyc/deg in pigmented C57BL/6 mice. Surprisingly, BALB/c mice showed reflexive head movements against the direction of the rotating stimulus. Contrast sensitivity was significantly lower in BALB/c mice (45% contrast at 0.064 cyc/deg) than in C57BL/6 mice (6% contrast). In the visual water task, visual acuity was 0.3 cyc/deg in BALB/c mice and 0.59 cyc/deg in C57BL/6 mice. Thus, the visual performance of BALB/c mice was significantly impaired in both behavioural tests - visual acuity was â¼ 0.3 cyc/deg lower than in C57BL/6 mice, and contrast sensitivity was reduced by a factor of â¼ 8. In BALB/c mice, visual cortical maps induced by stimulation of the contralateral eye were normal in both activation strength and retinotopic map quality. In contrast, maps induced by ipsilateral eye stimulation differed significantly between the strains - activity in a region representing 15° to 19° elevation in the visual field was significantly weaker in BALB/c mice than in C57BL/6 mice. Taken together, our observations show that BALB/c mice, like the albino animals of other species, have a significantly lower visual performance than C57BL/6 mice and a modified cortical representation of the ipsilateral eye that may impair stereopsis. Thus, our results caution against disregarding vision as a confounding factor in behavioural tests of neuropsychological disorders.
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Mapeamento Encefálico , Sensibilidades de Contraste , Camundongos Endogâmicos BALB C/fisiologia , Córtex Visual/fisiologia , Animais , Percepção de Profundidade , Camundongos , Camundongos Endogâmicos BALB C/anatomia & histologia , Camundongos Endogâmicos C57BL , Imagem Óptica , Pigmentação/fisiologia , Especificidade da Espécie , Córtex Visual/anatomia & histologiaRESUMO
Inhibitory interneurons comprise only about 20% of cortical neurons and thus constitute a clear minority compared to the vast number of excitatory projection neurons. They are, however, an influential minority with important roles in cortical maturation, function, and plasticity. In this paper, we will highlight the functional importance of cortical inhibition throughout brain development, starting with the embryonal formation of the cortex, proceeding by the regulation of sensory cortical plasticity in adulthood, and finishing with the GABA involvement in sensory information processing in old age.
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Córtex Cerebral/fisiologia , Interneurônios/fisiologia , Inibição Neural/fisiologia , Plasticidade Neuronal/fisiologia , Ácido gama-Aminobutírico/fisiologia , Envelhecimento/fisiologia , Animais , Movimento Celular/fisiologia , Córtex Cerebral/crescimento & desenvolvimento , Córtex Cerebral/patologia , Humanos , Interneurônios/patologia , Camundongos , Esquizofrenia/patologia , Esquizofrenia/fisiopatologia , Células Receptoras Sensoriais/fisiologia , Detecção de Sinal Psicológico/fisiologiaRESUMO
In a world with rapidly increasing population that competes for the earth's limited resources, cooperation is crucial. While research showed that empathizing with another individual in need enhances prosociality, it remains unclear whether correctly inferring the other's inner, mental states on a more cognitive level (i.e., mentalizing) elicits helping behavior as well. We applied a video-based laboratory task probing empathy and a performance measure of mentalizing in adult volunteers (N = 94) and assessed to which extent they were willing to help the narrators in the videos. We replicate findings that an empathy induction leads to more prosocial decisions. Crucially, we also found that correct mentalizing increases the willingness to help. This evidence helps clarify an inconsistent picture of the relation between mentalizing and prosociality.
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Empatia , Mentalização , Adulto , Comportamento de Ajuda , HumanosRESUMO
The progression of rod and cone degeneration in retinally degenerate (rd) mice ultimately results in a complete loss of photoreceptors and blindness. The inner retinal neurons survive and several recent studies using genetically targeted, light activated channels have made these neurons intrinsically light sensitive. We crossbred a transgenic mouse line expressing channelrhodopsin2 (ChR2) under the control of the Thy1 promoter with the Pde6b(rd1) mouse, a model for retinal degeneration (rd1/rd1). Approximately 30-40% of the ganglion cells of the offspring expressed ChR2. Extracellular recordings from ChR2-expressing ganglion cells in degenerated retinas revealed their intrinsic light sensitivity which was approximately 7 log U less sensitive than the scotopic threshold and approximately 2 log U less sensitive than photopic responses of normal mice. All ChR2-expressing ganglion cells were excited at light ON. The visual performance of rd1/rd1 mice and ChR2 rd1/rd1 mice was compared. Behavioral tests showed that both mouse strains had a pupil light reflex and they were able to discriminate light fields from dark fields in the visual water task. Cortical activity maps were recorded with optical imaging. The ChR2rd1/rd1 mice did not show a better visual performance than rd1/rd1 mice. In both strains the residual vision was correlated with the density of cones surviving in the peripheral retina. The expression of ChR2 under the control of the Thy1 promoter in retinal ganglion cells does not rescue vision.
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Células Fotorreceptoras de Vertebrados/fisiologia , Degeneração Retiniana/fisiopatologia , Células Ganglionares da Retina/fisiologia , Visão Ocular/fisiologia , Percepção Visual/fisiologia , Animais , Contagem de Células , Channelrhodopsins , Modelos Animais de Doenças , Técnicas In Vitro , Luz , Potenciais da Membrana/fisiologia , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Transgênicos , Estimulação Luminosa , Células Fotorreceptoras de Vertebrados/patologia , Células Fotorreceptoras Retinianas Cones/patologia , Células Fotorreceptoras Retinianas Cones/fisiologia , Degeneração Retiniana/patologia , Células Ganglionares da Retina/patologia , Córtex Visual/fisiopatologiaRESUMO
The Dark Triad (i.e., narcissism, psychopathy, Machiavellianism) has garnered intense attention over the past 15 years. We examined the structure of these traits' measure-the Dark Triad Dirty Dozen (DTDD)-in a sample of 11,488 participants from three W.E.I.R.D. (i.e., North America, Oceania, Western Europe) and five non-W.E.I.R.D. (i.e., Asia, Middle East, non-Western Europe, South America, sub-Saharan Africa) world regions. The results confirmed the measurement invariance of the DTDD across participants' sex in all world regions, with men scoring higher than women on all traits (except for psychopathy in Asia, where the difference was not significant). We found evidence for metric (and partial scalar) measurement invariance within and between W.E.I.R.D. and non-W.E.I.R.D. world regions. The results generally support the structure of the DTDD.
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Maquiavelismo , Narcisismo , Transtorno da Personalidade Antissocial , Ásia , Europa (Continente) , Feminino , Humanos , Masculino , América do NorteRESUMO
How little neurotransmission in the visual system is sufficient to promote decent visual capabilities? This question is of key importance for therapeutic approaches to restore vision in patients who suffer from degenerative retinal diseases. In the retinae of mice, mutant for the presynaptic scaffolding protein Bassoon (Bsn), signal transfer at photoreceptor ribbon synapses is severely disturbed due to impaired ribbon attachment to the active zone. We have used two different behavioural tasks and optical imaging of intrinsic signals to probe vision in young and adult Bsn-/- mice and their wild-type littermates. Here we show that while visual acuity was significantly reduced in mutants compared to controls, vision guided behavioural decisions and optical imaging revealed essentially unperturbed cortical signals and retinotopy in spite of the photoreceptor synaptopathy. In addition, both vision and visual cortical maps were adult-like at 4 weeks of age. These results show that (i) while Bassoon-dependent fast exocytosis is essential for normal vision surprisingly good visual performance can be achieved in the absence of synaptic ribbons, (ii) both the development and maintenance of visual cortical maps is independent of synaptic ribbons and (iii) visual development in the mutants is completed at 4 weeks of age indicating that later developing ectopic synapses do not affect vision. Thus, the central visual system can make use of slow and weak retinal signals to subserve surprisingly robust vision.
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Células Fotorreceptoras de Vertebrados/fisiologia , Sinapses/fisiologia , Transtornos da Visão/fisiopatologia , Córtex Visual/fisiopatologia , Percepção Visual/fisiologia , Envelhecimento/fisiologia , Animais , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Knockout , Proteínas do Tecido Nervoso/genética , Óptica e Fotônica/métodos , Retina/crescimento & desenvolvimento , Retina/fisiopatologia , Testes Visuais , Córtex Visual/irrigação sanguínea , Córtex Visual/crescimento & desenvolvimento , Vias Visuais/irrigação sanguínea , Vias Visuais/crescimento & desenvolvimento , Vias Visuais/fisiopatologiaRESUMO
We here show that social rank, as assessed by competition for a running wheel, influences ocular dominance plasticity in adult male mice. Dominant animals showed a clear ocular dominance shift after 4 days of MD, whereas their submissive cagemates did not. NMDA receptor activation, reduced GABA inhibition, and serotonin transmission were necessary for this plasticity, but not sufficient to explain the difference between dominant and submissive animals. In contrast, prefrontal dopamine concentration was higher in dominant than submissive mice, and systemic manipulation of dopamine transmission bidirectionally changed ocular dominance plasticity. Thus, we could show that a social hierarchical relationship influences ocular dominance plasticity in the visual cortex via higher-order cortices, most likely the medial prefrontal cortex. Further studies will be needed to elucidate the precise mechanisms by which this regulation takes place.
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Dominância Ocular , Hierarquia Social , Plasticidade Neuronal , Córtex Visual/fisiologia , Animais , Masculino , Camundongos Endogâmicos C57BL , Atividade Motora , Receptores de N-Metil-D-Aspartato/fisiologia , Serotonina/fisiologia , Predomínio Social , Ácido gama-Aminobutírico/fisiologiaRESUMO
There is convincing evidence that the deprivation of one sense can lead to adaptive neuronal changes in spared primary sensory cortices. However, the repercussions of late-onset sensory deprivations on functionality of the remaining sensory cortices are poorly understood. Using repeated intrinsic signal imaging we investigated the effects of whisker or auditory deprivation (WD or AD, respectively) on responsiveness of the binocular primary visual cortex (V1) in fully adult mice. The binocular zone of mice is innervated by both eyes, with the contralateral eye always dominating V1 input over ipsilateral eye input, the normal ocular dominance (OD) ratio. Strikingly, we found that 3 days of WD or AD induced a transient shift of OD, which was mediated by a potentiation of V1 input through the ipsilateral eye. This cross-modal effect was accompanied by strengthening of layer 4 synapses in V1, required visual experience through the ipsilateral eye and was mediated by an increase of the excitation/inhibition ratio in V1. Finally, we demonstrate that both WD and AD induced a long-lasting improvement of visual performance. Our data provide evidence that the deprivation of a non-visual sensory modality cross-modally induces experience dependent V1 plasticity and improves visual behavior, even in adult mice.
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Dominância Ocular , Plasticidade Neuronal , Privação Sensorial , Córtex Somatossensorial/fisiologia , Córtex Visual/fisiologia , Animais , Fenômenos Eletrofisiológicos , Feminino , Análise de Fourier , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Neurônios/fisiologia , Imagem Óptica , Receptores de N-Metil-D-Aspartato/fisiologia , Sinapses/fisiologia , Visão OcularRESUMO
The olfactory cortex, comprising the anterior olfactory cortex (AOC) and the anterior piriform cortex (PirC), is a model system for the study of neural plasticity. We investigated the structural imbalances of different transmitter systems induced in this area by an early traumatisation (methamphetamine [MA] intoxication) and/or environmental deprivation (isolated rearing [IR]), with the working hypothesis that such alterations will not occur in an isolated fashion, but in mutual interaction. Indeed, acetylcholine fibre density is increased by IR in both hemispheres of the PirC (left: +22%, p<0.01, right: +21%, p<0.05) and the left hemisphere of the AOC (+13%, p<0.05), while an early MA intoxication increases it in afterwards enriched-reared animals in the PirC (+14%/+17%, p<0.05), but decreases it in the AOC (-18%/-22%, p<0.001). The serotonin fibre density is increased by IR in the right PirC of saline-treated (+13%, p<0.01), but not of MA-traumatised gerbils. GABA and dopamine in the AOC show an inverse correlation, with dopamine innervation density being increased by IR (+30%, p<0.001) and MA (+26%, p<0.01), and GABA neuropil density being reduced. Furthermore, switches in hemispheric laterality occur in the AOC. These results demonstrate the complex recursive interactions in structural cortical plasticity.
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Adaptação Fisiológica , Estimulantes do Sistema Nervoso Central/toxicidade , Meio Ambiente , Metanfetamina/toxicidade , Neurotransmissores/metabolismo , Condutos Olfatórios/efeitos dos fármacos , Análise de Variância , Animais , Lateralidade Funcional/fisiologia , Gerbillinae , Processamento de Imagem Assistida por Computador , Imuno-Histoquímica/métodos , Masculino , Condutos Olfatórios/metabolismo , Isolamento SocialRESUMO
The maturation of cortical inhibition provided by parvalbumin-containing basket cells derived from the medial ganglionic eminence (MGE) is a key event in starting the enhanced visual cortical plasticity during the critical period. Although it is generally assumed that a further increase in inhibition closes the critical period again, it was recently shown that embryonic interneurons derived from the MGE can induce an additional, artificial critical period when injected into the visual cortex of young mice. It has, however, remained open whether this effect was indeed specific for MGE-derived cells, and whether critical period-like plasticity could also be induced in fully adult animals. To clarify these issues, we injected explants from either the MGE or the caudal ganglionic eminence (CGE) into the visual cortices of fully adult mice, and performed monocular deprivation 33 days later for 4 days. Animals implanted with MGE cells, but not with CGE cells, showed marked ocular dominance plasticity. Immunohistochemistry confirmed that the injected cells from both sources migrated far in the host cortex, that most developed into neurons producing GABA, and that only cells from the MGE expressed parvalbumin. Thus, our results confirm that the plasticity-inducing effect of embryonic interneurons is specific for cells from the MGE, and is independent of the host animal's age.
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Dominância Ocular , Interneurônios/fisiologia , Eminência Mediana/fisiologia , Plasticidade Neuronal , Córtex Visual/fisiologia , Animais , Movimento Celular , Neurônios GABAérgicos/fisiologia , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Estimulação Luminosa , Privação Sensorial/fisiologia , Percepção Visual/fisiologiaRESUMO
Narcissistic grandiosity is characterized by overt expressions of feelings of superiority and entitlement, while narcissistic vulnerability reflects hypersensitivity and introversive self-absorbedness. Clinical evidence suggests that grandiosity is accompanied by vulnerable aspects, pointing to a common foundation. Subclinical personality research, however, views grandiose and vulnerable narcissism as independent traits. Grandiose narcissism displays substantial correlation with extraversion, while vulnerable narcissism correlates highly with introversion. We investigated if (1) controlling for intro-/extraversion might reveal a "common core" of grandiose and vulnerable narcissism, and if (2) the correlation between both aspects might be higher at higher levels of narcissism. Latent variable structural equation modeling and segmented regression analysis confirmed these hypotheses in a large non-clinical sample (N = 1,006). Interindividual differences in intro-/extraversion mask the common core of grandiose and vulnerable narcissism. The association between both aspects increases at high levels (upper 10%) of grandiose narcissism, which suggests a possible transition to clinically relevant (pathological) narcissism.
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Methylphenidate (MPH) is the most commonly used drug to treat attention deficit/hyperactivity disorder (ADHD) in children effectively and safely. In spite of its widespread application throughout one of the most plastic and sensitive phases of brain development, very little is known to date about its long-term effects on brain structure and function. Hence, this short review updates the influence of MPH on brain development, since recent human and animal studies suggest that MPH alters the dopaminergic system with long-term effects beyond the termination of treatment.Animal studies imply that the effects of MPH may depend on the neural responder system: Whereas structural and functional parameters are improved by MPH in animals with psychomotor impairments, they remain unaltered or get worse in healthy controls. While recent behavioural studies do not fully support such a differential effect of MPH in ADHD, the animal studies certainly prompt for further investigation of this issue. Furthermore, the abuse of MPH, when (rarely) intravenously applied, may even impair the maturation of dopaminergic fibres in subcortical brain areas. This argues for careful clinical assessment and diagnostics of ADHD symptomatology not only in conjunction with the prescription of MPH. Hence, one should be assured that MPH is only given to children with clear ADHD symptomatology leading to psychosocial impairment. The animal data suggest that under these conditions MPH is supportive for brain development and the related behaviour in children with ADHD.
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We describe a strongly biologically motivated artificial neural network approach to model neurogenesis and synaptic turnover as it naturally occurs for example in the hippocampal dentate gyrus (DG) of the developing and adult mammalian and human brain. The results suggest that cell proliferation (CP) has not only a functional meaning for computational tasks and learning but is also relevant for maintaining homeostatic stability of the neural activity. Moderate rates of CP buffer disturbances in input activity more effectively than networks without or very high CP. Up to a critical mark an increase of CP enhances synaptogenesis which might be beneficial for learning. However, higher rates of CP are rather ineffective as they destabilize the network: high CP rates and a disturbing input activity effect a reduced cell survival. By these results the simulation model sheds light on the recurrent interdependence of structure and function in biological neural networks especially in hippocampal circuits and the interacting morphogenetic effects of neurogenesis and synaptogenesis.