The developing human connectome project: A minimal processing pipeline for neonatal cortical surface reconstruction.

The Developing Human Connectome Project (dHCP) seeks to create the first 4-dimensional connectome of early life. Understanding this connectome in detail may provide insights into normal as well as abnormal patterns of brain development. Following established best practices adopted by the WU-MINN Human Connectome Project (HCP), and pioneered by FreeSurfer, the project utilises cortical surface-based processing pipelines. In this paper, we propose a fully automated processing pipeline for the structural Magnetic Resonance Imaging (MRI) of the developing neonatal brain. This proposed pipeline consists of a refined framework for cortical and sub-cortical volume segmentation, cortical surface extraction, and cortical surface inflation, which has been specifically designed to address considerable differences between adult and neonatal brains, as imaged using MRI. Using the proposed pipeline our results demonstrate that images collected from 465 subjects ranging from 28 to 45 weeks post-menstrual age (PMA) can be processed fully automatically; generating cortical surface models that are topologically correct, and correspond well with manual evaluations of tissue boundaries in 85% of cases. Results improve on state-of-the-art neonatal tissue segmentation models and significant errors were found in only 2% of cases, where these corresponded to subjects with high motion. Downstream, these surfaces will enhance comparisons of functional and diffusion MRI datasets, supporting the modelling of emerging patterns of brain connectivity.

EXODUS: Stable and efficient training of spiking neural networks.

Introduction: Spiking Neural Networks (SNNs) are gaining significant traction in machine learning tasks where energy-efficiency is of utmost importance. Training such networks using the state-of-the-art back-propagation through time (BPTT) is, however, very time-consuming. Previous work employs an efficient GPU-accelerated backpropagation algorithm called SLAYER, which speeds up training considerably. SLAYER, however, does not take into account the neuron reset mechanism while computing the gradients, which we argue to be the source of numerical instability. To counteract this, SLAYER introduces a gradient scale hyper parameter across layers, which needs manual tuning. Methods: In this paper, we modify SLAYER and design an algorithm called EXODUS, that accounts for the neuron reset mechanism and applies the Implicit Function Theorem (IFT) to calculate the correct gradients (equivalent to those computed by BPTT). We furthermore eliminate the need for ad-hoc scaling of gradients, thus, reducing the training complexity tremendously. Results: We demonstrate, via computer simulations, that EXODUS is numerically stable and achieves comparable or better performance than SLAYER especially in various tasks with SNNs that rely on temporal features.

Adversarial attacks on spiking convolutional neural networks for event-based vision.

Event-based dynamic vision sensors provide very sparse output in the form of spikes, which makes them suitable for low-power applications. Convolutional spiking neural networks model such event-based data and develop their full energy-saving potential when deployed on asynchronous neuromorphic hardware. Event-based vision being a nascent field, the sensitivity of spiking neural networks to potentially malicious adversarial attacks has received little attention so far. We show how white-box adversarial attack algorithms can be adapted to the discrete and sparse nature of event-based visual data, and demonstrate smaller perturbation magnitudes at higher success rates than the current state-of-the-art algorithms. For the first time, we also verify the effectiveness of these perturbations directly on neuromorphic hardware. Finally, we discuss the properties of the resulting perturbations, the effect of adversarial training as a defense strategy, and future directions.

The Developing Human Connectome Project Neonatal Data Release.

The Developing Human Connectome Project has created a large open science resource which provides researchers with data for investigating typical and atypical brain development across the perinatal period. It has collected 1228 multimodal magnetic resonance imaging (MRI) brain datasets from 1173 fetal and/or neonatal participants, together with collateral demographic, clinical, family, neurocognitive and genomic data from 1173 participants, together with collateral demographic, clinical, family, neurocognitive and genomic data. All subjects were studied in utero and/or soon after birth on a single MRI scanner using specially developed scanning sequences which included novel motion-tolerant imaging methods. Imaging data are complemented by rich demographic, clinical, neurodevelopmental, and genomic information. The project is now releasing a large set of neonatal data; fetal data will be described and released separately. This release includes scans from 783 infants of whom: 583 were healthy infants born at term; as well as preterm infants; and infants at high risk of atypical neurocognitive development. Many infants were imaged more than once to provide longitudinal data, and the total number of datasets being released is 887. We now describe the dHCP image acquisition and processing protocols, summarize the available imaging and collateral data, and provide information on how the data can be accessed.

Event-Based Face Detection and Tracking Using the Dynamics of Eye Blinks.

We present the first purely event-based method for face detection using the high temporal resolution properties of an event-based camera to detect the presence of a face in a scene using eye blinks. Eye blinks are a unique and stable natural dynamic temporal signature of human faces across population that can be fully captured by event-based sensors. We show that eye blinks have a unique temporal signature over time that can be easily detected by correlating the acquired local activity with a generic temporal model of eye blinks that has been generated from a wide population of users. In a second stage once a face has been located it becomes possible to apply a probabilistic framework to track its spatial location for each incoming event while using eye blinks to correct for drift and tracking errors. Results are shown for several indoor and outdoor experiments. We also release an annotated data set that can be used for future work on the topic.

LUMOR: an app for standardized control and monitoring of a porcine lung and its nutrient cycle.

The outcome of the EU-funded project ElBik has been the lung simulator 'iLung', which imitates an actively breathing human lung with a porcine lung. In order to keep the explanted lung in a nearly physiological state during transportation from the slaughterhouse to the ventilation laboratory the tissue needs to be nourished and temperature controlled. The Project AlveoPic designs a mobile transport vehicle implementing an ISO/IEEE 11073-20601 compliant communication interface for the exchange of the physical parameters, alert messages and setpoint-values. An appropriate 11073 domain information model is designed and limitations of the defined services and attributes are identified. For monitoring purposes the Android App LUMOR is implemented providing a user with an easy-to-handle GUI. It was found, that alert capabilities and remote set features are not well supported in ISO/IEEE 11073-20601 at the moment and possible workarounds are discussed.