Detalhe da pesquisa
1.
Identification of potent and selective MTH1 inhibitors.
Bioorg Med Chem Lett
; 26(6): 1503-1507, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26898335
2.
Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling.
Bioorg Med Chem
; 24(10): 2215-34, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27085672
3.
Impact of hydrolysis-mediated clearance on the pharmacokinetics of novel anaplastic lymphoma kinase inhibitors.
Drug Metab Dispos
; 41(1): 238-47, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23118327
4.
Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.
Bioorg Med Chem Lett
; 22(12): 4089-93, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22595176
5.
Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.
Bioorg Med Chem Lett
; 22(15): 4967-74, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22765895
6.
Corrigendum to "Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling" [Bioorg. Med. Chem. 24 (2016) 2215-2234].
Bioorg Med Chem
; 24(13): 3093, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27234892
7.
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
J Med Chem
; 64(15): 11302-11329, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34292726
8.
Optimisation of a series of potent, selective and orally bioavailable GlyT1 inhibitors.
Bioorg Med Chem Lett
; 19(8): 2235-9, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19318248
9.
The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors.
J Med Chem
; 60(3): 1105-1125, 2017 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28001399
10.
The in vivo properties of pagoclone in rat are most likely mediated by 5'-hydroxy pagoclone.
Neuropharmacology
; 50(6): 677-89, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16430927
11.
Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders.
J Med Chem
; 49(1): 35-8, 2006 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-16392789
12.
A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.
J Med Chem
; 49(8): 2600-10, 2006 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16610803
13.
Rapid development of piperidine carboxamides as potent and selective anaplastic lymphoma kinase inhibitors.
J Med Chem
; 55(4): 1698-705, 2012 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22263917
14.
The discovery and optimization of a novel class of potent, selective, and orally bioavailable anaplastic lymphoma kinase (ALK) inhibitors with potential utility for the treatment of cancer.
J Med Chem
; 55(14): 6523-40, 2012 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22734674
15.
Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1.
ACS Med Chem Lett
; 1(7): 350-4, 2010 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900218
16.
Imidazo[1,2-a]pyrimidines as functionally selective GABA(A) ligands.
Bioorg Med Chem Lett
; 16(5): 1175-9, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16406613
17.
Imidazo[1,2-b][1,2,4]triazines as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.
Bioorg Med Chem Lett
; 16(6): 1477-80, 2006 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16386900