Improvement of UCVA, BCVA, and Intraocular Pressure after Phakic Posterior Chamber Intraocular Lens Implantation for Myopia.

Objective: The purpose of this study is to explore the artificial lens planting of the back room shape of the crystal eye eyes and The clinical effect of ICL in patients with myopia. Methods: A Retrospective Study Spanning from 2021 to 2023 within Huai'an First People's Hospital. This study involves the comparative analysis of 100 eyes subjected to 'Crystalline Lens Extraction + IOL' and 100 eyes undergoing 'ICL' treatment. We evaluate various postoperative parameters, including near and distant visual acuity, Visual Acuity (CVA), Best-Corrected Visual Acuity (BCVA), refractive outcomes, endothelial cell count, glare sensitivity, and the incidence of macular edema. The control group underwent Crystalline Lens Extraction + IOL, and the observation group underwent 'ICL' treatment. Visual acuity recovery, intraocular pressure, endothelial cell count, adverse reactions, and therapeutic effect were compared between the two groups. Results: The CVA before treatment and the IOP and endothelial cell count before and after treatment in the observation group were similar to those in the control group, and the differences were not statistically significant (P > .05). The CVA, BCVA, and refraction after treatment in the observation group were all higher than those in the control group, and the differences were statistically significant (P < .05). The number of people with significant and effective treatment effects in the observation group (total effective rate 98.00%) was higher than that in the control group (82.00%), and the difference was statistically significant (P < .05). Conclusions: The implantation of 'ICL' treatment in cases of myopia demonstrates favorable surgical outcomes in clinical practice. It effectively enhances postoperative visual function recovery while minimizing the risk of adverse reactions. The ICL implantation procedure is irreplaceable in the treatment of myopia.

CCDN-DETR: A Detection Transformer Based on Constrained Contrast Denoising for Multi-Class Synthetic Aperture Radar Object Detection.

The effectiveness of the SAR object detection technique based on Convolutional Neural Networks (CNNs) has been widely proven, and it is increasingly used in the recognition of ship targets. Recently, efforts have been made to integrate transformer structures into SAR detectors to achieve improved target localization. However, existing methods rarely design the transformer itself as a detector, failing to fully leverage the long-range modeling advantages of self-attention. Furthermore, there has been limited research into multi-class SAR target detection. To address these limitations, this study proposes a SAR detector named CCDN-DETR, which builds upon the framework of the detection transformer (DETR). To adapt to the multiscale characteristics of SAR data, cross-scale encoders were introduced to facilitate comprehensive information modeling and fusion across different scales. Simultaneously, we optimized the query selection scheme for the input decoder layers, employing IOU loss to assist in initializing object queries more effectively. Additionally, we introduced constrained contrastive denoising training at the decoder layers to enhance the model's convergence speed and improve the detection of different categories of SAR targets. In the benchmark evaluation on a joint dataset composed of SSDD, HRSID, and SAR-AIRcraft datasets, CCDN-DETR achieves a mean Average Precision (mAP) of 91.9%. Furthermore, it demonstrates significant competitiveness with 83.7% mAP on the multi-class MSAR dataset compared to CNN-based models.

HLA-B*35:01-mediated activation of emodin-specific T cells contributes to Polygonum multiflorum thunb. -induced liver injury in mice.

ETHNOPHARMACOLOGICAL RELEVANCE: HLA-B*35:01 has been identified as a risk allele for Polygonum multiflorum Thunb.-induced liver injury (PMLI). However, the immune mechanism underlying HLA-B*35:01-mediated PMLI remains unknown. AIM OF THE STUDY: To characterize the immune mechanism of HLA-B*35:01-mediated PMLI. MATERIALS AND METHODS: Components of P. multiflorum (PM) bound to the HLA-B*35:01 molecule was screened by immunoaffinity chromatography. Both wild-type mice and HLA-B*35:01 transgenic (TG) mice were treated with emodin. The levels of transaminases, histological changes and T-cell response were assessed. Splenocytes from emodin-treated mice were isolated and cultured in vitro. Phenotypes and functions of T cells were characterized upon drug restimulation using flow cytometry or ELISA. Emodin-pulsed antigen-presenting cells (APCs) or glutaraldehyde-fixed APCs were co-cultured with splenocytes from emodin-treated transgenic mice to detect their effect on T-cell activation. RESULTS: Emodin, the main component of PM, could non-covalently bind to the HLA-B*35:01-peptide complexes. TG mice were more sensitive to emodin-induced immune hepatic injury, as manifested by elevated aminotransferase levels, infiltration of inflammatory cells, increased percentage of CD8+T cells and release of effector molecules in the liver. However, these effects were not observed in wild-type mice. An increase in percentage of T cells and the levels of interferon-γ, granzyme B, and perforin was detected in emodin-restimulated splenocytes from TG mice. Anti-HLA-I antibodies inhibited the secretion of these effector molecules induced by emodin. Mechanistically, emodin-pulsed APCs failed to stimulate T cells, while fixed APCs in the presence of emodin could elicit the secretion of T cell effector molecules. CONCLUSION: The HLA-B*35:01-mediated CD8+ T cell reaction to emodin through the P-I mechanism may contribute to P. multiflorum-induced liver injury.