Sandwich-Structured Quasi-Solid Polymer Electrolyte Enables High-Capacity, Long-Cycling, and Dendrite-Free Lithium Metal Battery at Room Temperature.

The insufficient ionic conductivity, limited lithium-ion transference number (tLi +), and high interfacial impedance severely hinder the practical application of quasi-solid polymer electrolytes (QSPEs). Here, a sandwich-structured polyacrylonitrile (PAN) based QSPE is constructedin which MXene-SiO2 nanosheets act as a functional filler to facilitate the rapid transfer of lithium-ion in the QSPE, and a polymer and plastic crystalline electrolyte (PPCE) interface modification layer is coated on the surface of the PAN-based QSPE of 3 wt.% MXene-SiO2 (SS-PPCE/PAN-3%) to reduce interfacial impedance. Consequently, the synthesized SS-PPCE/PAN-3% QSPE delivers a promising ionic conductivity of ≈1.7 mS cm-1 at 30 °C, a satisfactory tLi + of 0.51, and a low interfacial impedance. As expected, the assembled Li symmetric battery with SS-PPCE/PAN-3% QSPE can stably cycle more than 1550 h at 0.2 mA cm-2 . The Li||LiFePO4 quasi-solid-state lithium metal battery (QSSLMB) of this QSPE exhibits a high capacity retention of 81.5% after 300 cycles at 1.0 C and at RT. Even under the high-loading cathode (LiFePO4  ≈ 10.0 mg cm-2 ) and RT, the QSSLMB achieves a superior area capacity and good cycling performance. Besides, the assembled high voltage Li||NMC811(loading ≈ 7.1 mg cm-2 ) QSSLMB has potential applications in high-energy fields.

Structural, energetic and dynamic investigation of poly(ethylene oxide) in imidazolium-based ionic liquids with different cationic structures.

In this work, two imidazolium-based ionic liquids (ILs) with different cations including dications (DIL) and monocations (MIL) were blended with poly(ethylene oxide) (PEO). The influence of ILs' structure on the structural and dynamic properties of a PEO/IL system was investigated by molecular dynamics (MD) simulation and density functional theory (DFT) methods. The simulation results show that DIL exhibits weaker interaction with PEO than MIL due to a stronger IL aggregation effect. The intermolecular interaction also makes the PEO chain tend to organize around the imidazolium ring of ILs, which causes the conformational entropy loss. Compared with PEO/MIL, this phenomenon is more significant in PEO/DIL because of the double positive centers of the dication and a longer hydrogen bond lifetime. MD simulation also demonstrates that DIL could act as a "crosslinker" to promote the formation of a physical crosslinking network which has strong dependence on the concentration of IL. The competition between physical crosslinking and plasticizing effects induces non-monotonic variations of relaxation time in PEO/DIL, which is consistent with its unusual change of the glass transition temperature (Tg). Despite stronger hydrogen bonding interactions between PEO and MIL demonstrated by atom-in-molecules (AIM) and reduced density gradient (RDG) analysis, the segmental mobility is slower in PEO/DIL according to the MSD curve. These differences in multiple structural or energetic factors finally lead to different conductive mechanisms and hence obtain different ionic conductivities.

Cultivar-specific response of rhizosphere bacterial community to uptake of cadmium and mineral elements in rice (Oryza sativa L.).

Toxic metal-contaminated farmland from Cadmium (Cd) can enhance the accumulation of Cd and impair the absorption of mineral elements in brown rice. Although several studies have been conducted on Cd exposure on rice, little has been reported on the relationship between Cd and mineral elements in brown rice and the regulatory mechanism of rhizosphere microorganisms during element uptake. Thus, a field study was undertaken to screen japonica rice cultivars with low Cd and high mineral elements levels, analyze the quantitative relationship between Cd and seven mineral elements, and investigate the cultivar-specific response of rice rhizosphere bacterial communities to differences in Cd and mineral uptake in japonica rice. Results showed that Huaidao-9 and Xudao-7 had low Cd absorption and high amounts of mineral nutrient elements (Fe, Zn, Mg, and Ca, LCHM group), whereas Zhongdao-1 and Xinkedao-31 showed opposite accumulation characteristics (HCLM group). Stepwise regression analysis showed that zinc, iron, and potassium are the key minerals that affect Cd accumulation in japonica rice and zinc was the most important factor, accounting for 68.99 %. The accumulation of Cd and mineral elements is potentially associated with rhizosphere soil bacteria. Taxa enriched in the LCHM rhizosphere (phyla Acidobacteriota and MBNT15) indicated the high nutrient characteristics of the soil and reduced activity of Cd in soil. The HCLM rhizosphere was highly colonized by metal-activating bacteria (Actinobacteria), lignin-degrading bacteria (Actinobacteria and Chlorofexi), and bacteria scavenging nutrients and trace elements (Anaerolinea and Ketobacter). Moreover, the differences in the uptake of Cd and mineral elements affected predicted functions of microbial communities, including sulfur oxidation and sulfur derivative formation, human or plant pathogen, and functions related to the iron oxidation and nitrate reduction. The results indicate a potential association of Cd and mineral elements uptake and accumulation with rhizosphere bacteria in rice, thus providing theoretical basis and a new perspective on the maintenance of rice security and high quality simultaneously.

Influence of ionic liquids on the chain dynamics and enthalpy relaxation of poly(methyl methacrylate).

Imidazolium ionic liquids (ILs) with various alkyl chain lengths on the cations ([Cnmim]+, n = 2, 4 and 8) and different combined anions ([TFSI]- and [PF6]-) were blended with poly(methyl methacrylate) (PMMA), and the effects of the IL structure on the chain dynamics of PMMA were experimentally investigated by rheology and DSC measurements combined with a simulation method. The results indicate that the interaction between PMMA and ILs becomes stronger as the alkyl chain length on the imidazolium ring increases or the anion changes from [PF6]- to [TFSI]-. As a result, a higher critical entanglement concentration and a larger entanglement molecular weight of PMMA were found in [C8mim][TFSI] due to the stiffer conformation. Molecular dynamics (MD) simulations further demonstrated stronger interactions between PMMA and ILs with longer cationic alkyl chain lengths or [TFSI]- anions, which showed smaller Flory-Huggins interaction parameters and larger radii of gyration, Rg. However, the larger size of alkyl chains or [TFSI]- anions produced a larger free volume in the system as evidenced by positron annihilation lifetime spectroscopy (PALS), which competed with the molecular interaction and dominated the segmental motion. Therefore, a lower Tg and accelerated segmental relaxation were observed. Compared to alkyl chain length, the effect of anions on the interactions between ILs and PMMA is more prominent.

Vorticity-Aligned Droplet Bands in Sheared Immiscible Polymer Blends Induced by Solid Particles.

The spatiotemporal organization of complex fluids under flow can be strongly affected by incorporating solid particles. Here, we report that a monolayer of interfacially active microspheres preferentially wetted by the matrix phase can bridge droplets into vorticity-aligned bands in immiscible polymer blends at intermediate particle concentrations and low shear rates. Strong particle bridging ability and the formation of rigid anisotropic droplet bands with a negligible inertia effect in the Newtonian matrix are suggested to be responsible for the vorticity orientation of droplet bands during slow shear flow, which could be understood based on Jeffery orbit theory in the framework of fluid mechanics and strong confinement effect acted by shear walls and adjacent bands. However, increasing the aspect ratio of particles could restrain the formation of anisotropic bands because of reduced particle coverage and promoted droplet coalescence induced by sharp particle corners, increased and uneven distribution of particle aggregates in the matrix phase, and weakened particle bridging ability.

Maize microRNA166 Inactivation Confers Plant Development and Abiotic Stress Resistance.

MicroRNAs are important regulators in plant developmental processes and stress responses. In this study, we generated a series of maize STTM166 transgenic plants. Knock-down of miR166 resulted in various morphological changes, including rolled leaves, enhanced abiotic stress resistance, inferior yield-related traits, vascular pattern and epidermis structures, tassel architecture, as well as abscisic acid (ABA) level elevation and indole acetic acid (IAA) level reduction in maize. To profile miR166 regulated genes, we performed RNA-seq and qRT-PCR analysis. A total of 178 differentially expressed genes (DEGs) were identified, including 118 up-regulated and 60 down-regulated genes. These DEGs were strongly enriched in cell and intercellular components, cell membrane system components, oxidoreductase activity, single organism metabolic process, carbohydrate metabolic process, and oxidation reduction process. These results indicated that miR166 plays important roles in auxin and ABA interaction in monocots, yet the specific mechanism may differ from dicots. The enhanced abiotic stress resistance is partly caused via rolling leaves, high ABA content, modulated vascular structure, and the potential changes of cell membrane structure. The inferior yield-related traits and late flowering are partly controlled by the decreased IAA content, the interplay of miR166 with other miRNAs and AGOs. Taken together, the present study uncovered novel functions of miR166 in maize, and provide insights on applying short tandem target mimics (STTM) technology in plant breeding.

Controlling the Orientation of Droplets in Ellipsoid-Filled Polymeric Emulsions with Particle Parameters and Flow Conditions.

The effect of particle parameters [aspect ratio (AR) and concentration] and flow conditions (gap spacing and shear rate) on droplet orientation deformation behavior in polystyrene (PS) particle-filled binary polymeric emulsions is investigated by using a rheo-optical technique and confocal microscopy. Interesting vorticity orientation behavior is achieved by tailoring experimental conditions to yield rigid anisotropic droplets during slow confined shear flow. PS ellipsoids with a high AR are found to reside both at the fluid interface in a monolayer side-on state and inside droplets, leading to the formation of rigid anisotropic droplets because of the interfacial/bulk jamming effect at appropriate particle concentrations. In unconfined bulk samples, droplets with a vorticity orientation can also be observed under the wall migration effect and confinement effect arising from nearby droplets. However, the overly strong wall confinement effect remarkably facilitates the coalescence of vorticity-aligned droplets during slow shear, eventually leading to the formation of a long stringlike phase aligning along the flow direction. High shear rates generate refined droplets with lower particle coverage and weak rigidity, which restrain the formation of anisotropic droplets and thus suppress the droplet vorticity orientation.

Thermally Reversible and Irreversible Phase Transition Behaviors in Poly(ethylene oxide)/Ionic Liquid Mixtures.

The irreversible and reversible phase transition behaviors during phase separation-recovery (heating-cooling) cycles for poly(ethylene oxide)/1-ethyl-3-methylimidazolium tetrafluoroborate ionic liquid (PEO/[EMIM][BF4 ]) mixtures with a lower critical solution temperature phase diagram are reported for the first time. The evident differential scanning calorimetry endothermic and exothermic peaks are observed during the heating-cooling scan cycles near the phase boundary, in which the large heat loss for samples below the critical composition (60 wt% PEO) and obvious downward shift of phase transition temperature for all the compositions between the first and second cycles are particularly attractive. After the first recovery process, a reversible behavior during the next cycles is expected. These interesting phenomena are further confirmed by optical microscopy and Fourier-transform infrared measurements. It is demonstrated that the disruption and partial recovery of the hydrogen bonds, combined with the conformational change of PEO chains, can contribute to this irreversible behavior as well as a conversion to reversible phase transition behavior.

Mobilization and removing of cadmium from kidney by GMDTC utilizing renal glucose reabsorption pathway.

Chronic exposure to cadmium compounds (Cd(2+)) is one of the major public health problems facing humans in the 21st century. Cd(2+) in the human body accumulates primarily in the kidneys which leads to renal dysfunction and other adverse health effects. Efforts to find a safe and effective drug for removing Cd(2+) from the kidneys have largely failed. We developed and synthesized a new chemical, sodium (S)-2-(dithiocarboxylato((2S,3R,4R,5R)-2,3,4,5,6 pentahydroxyhexyl)amino)-4-(methylthio) butanoate (GMDTC). Here we report that GMDTC has a very low toxicity with an acute lethal dose (LD50) of more than 10,000mg/kg or 5000mg/kg body weight, respectively, via oral or intraperitoneal injection in mice and rats. In in vivo settings, up to 94% of Cd(2+) deposited in the kidneys of Cd(2+)-laden rabbits was removed and excreted via urine following a safe dose of GMDTC treatment for four weeks, and renal Cd(2+) level was reduced from 12.9µg/g to 1.3µg/g kidney weight. We observed similar results in the mouse and rat studies. Further, we demonstrated both in in vitro and in animal studies that the mechanism of transporting GMDTC and GMDTC-Cd complex into and out of renal tubular cells is likely assisted by two glucose transporters, sodium glucose cotransporter 2 (SGLT2) and glucose transporter 2 (GLUT2). Collectively, our study reports that GMDTC is safe and highly efficient in removing deposited Cd(2+) from kidneys assisted by renal glucose reabsorption system, suggesting that GMDTC may be the long-pursued agent used for preventive and therapeutic purposes for both acute and chronic Cd(2+) exposure.

Dynamics of particle-covered droplets in shear flow: unusual breakup and deformation hysteresis.

The dynamics of droplets exhibiting an elastic interface generated by a percolated network of particle aggregates at the interface is microscopically investigated in a counter rotating shear flow device. The droplet deformation is significantly suppressed by interfacially localized nanoparticles, even at high Ca numbers, resulting in suspension-like behavior at high particle coverage. When the Ca number surpasses a critical value, the particle network locally breaks up, resulting in localized deformability of the interface and breakup dynamics characterized by extremely irregular shapes. Finally, the destruction of the interfacial network results in hysteresis effects in the droplet deformation.

Unusual phase separation and rheological behavior of poly(ethylene oxide)/ionic liquid mixtures with specific interactions.

The phase separation behavior of poly(ethylene oxide) (PEO) in ionic liquid 1-ethyl-3-methylimidazolium tetrafluoroborate ([EMIM][BF4]) was investigated by rheological, optical microscopy, FT-IR and DSC measurements. It is demonstrated that specific interactions, particularly the hydrogen bonding between PEO and the ionic liquids as evidenced by FT-IR, in which a subtle but apparent absorption peak shift near the phase transition appears, account for the unusual low critical solution temperature (LCST) phase separation. Unlike the typical trend in which the storage modulus G' simply increases with temperature near the phase boundary for polymer blends without specific interaction, in our study, a novel "V-shaped" rheological response is observed, namely a dip in G' followed by an upturn, especially at low PEO concentration (<50 wt%). The magnitude of the "V" dip has heating rate and frequency dependences, while Tr (the phase transition temperature) is almost unchanged with heating rate and frequency. Upon increasing the alkyl chain length on the imidazolium ring from an ethyl to a butyl, the "V-shape" becomes more prominent and shifts to higher temperature, which is consistent with the results of FT-IR and DSC, evidently due to the stronger hydrogen bonding interaction between PEO and [BMIM][BF4] than [EMIM][BF4]. This unusual "V" dip might be tentatively ascribed to the coupling effects of the breaking of the "hydrogen bonding cage" formed between PEO chains and IL molecules and dissolution of the heterogeneous clusters as verified by FT-IR and TEM, respectively, and the following upturn is dominated by the interface formation upon phase separation.

Suppression of wetting-induced percolation-to-droplet transition in near-critical polymer blend films by nanoparticles.

A new kind of percolation-to-droplet transition (PDT) caused by selective wetting was identified in near-critical polymer blend films. Nanoscale particles proved to possess superior ability in suppressing this morphological transition.

Droplet coalescence and clustering behavior in microsphere-filled polymeric emulsions under shear flow: the key role of asymmetric interfacial affinities.

The flow-induced spatial organization of the droplet phase in ternary polymeric emulsions consisting of two Newtonian fluids, namely polyisobutylene (PIB) and polydimethylsiloxane (PDMS), in the presence of a small amount of solid polystyrene (PS) microspheres are explored by direct flow visualization. The results suggest that the asymmetric affinities of interfacially located PS microspheres to two fluid components lead to diverse flow-induced morphologies in PIB/PDMS blends with different compositions. In 10/90 blends where microspheres are preferentially wetted by the PIB droplets, significantly promoted coalescence of PIB droplets is observed. Increasing the loading of microspheres or changing the shear rate will alter the size and spatial distribution of PIB droplets. In contrast, in the inverse 90/10 blends where microspheres are wetted by the continuous PIB phase, bridging of PDMS droplets is found, leading to the generation of string-like or grape-like clusters. These results indicate that the flow-induced morphology of PIB/PDMS blends in the presence of PS microspheres is not only determined by the experimental conditions such as shear rate but also to a large extent by the asymmetric interfacial affinities of microspheres for fluid components.

A bead-spring model for running and tumbling of flagellated swimmers: detailed predictions compared to experimental data for E. coli.

To study the swimming of the multi-flagellated bacterium Escherichia coli, we deploy a bead-spring hydrodynamic model (Watari and Larson 2010), whose body and flagellar geometry, motor torques, and motor reversals are adjusted to match the experimental observations of the Berg group (Turner et al. 2000; Darnton et al. 2007) during both running and tumbling of the bacterium. In this model, hydrodynamic interactions, which drive swimming, flagellar bundling, and unbundling during swimming and tumbling, are imposed by treating the beads as Stokeslets, imposing torques and counter-torques on the body and flagellum at the flexible joint connecting them to represent the action of motor, and using the Rotne-Prager tensor to model their hydrodynamic interactions with other beads. We explore the behavior of coarse-grained (60-bead) and refined (120-bead) versions of the model, and show that predictions of running speed, helical and body rotation rates, body wobble rates and angles, average tumbling angles, range of tumbling angles, and flagellar re-bundling times are in good agreement with experimental observations by Berg and coworkers. We find that variation in tumbling angle arises from variation in flagellar number and location on the bacterial body, variations in polymorphic transitions of the filaments, and especially from variations in the duration of the tumbling time, which is roughly linearly correlated with tumbling time up to tumbling angles of around 40-50° and more weakly thereafter. The accuracy of the model suggests its usefulness for future studies of swimming of other flagellated swimmers, for predictions of collective phenomena, and for tuning parameters of coarser-grained swimmer models to achieve greater realism.

Two-dimensional MXene nanosheets on nano-scale fibrils in hierarchical porous structure to achieve ultra-high sensitivity.

The complex hybrid nanostructure combining a two-dimensional (2D) conductive material and a hierarchical nanoscale skeleton plays an important role to enhance its piezoresistive sensitivity. To construct such a novel hybrid nanostructure, a piezoresistive sensor was designed with the following strategy to take the full advantages of 2D MXene and nanoscale fibrils: ethylene oxide propylene oxide random copolymer (EOPO) was grafted to ethylene-vinyl alcohol (EVOH) molecular chains and was foamed by an environmentally-friendly supercritical CO2 (scCO2) foaming technology to fabricate abundant nanoscale EVOH fibrils surrounding micropores; MXene featured as a 2D structure of nanoscale size that strongly interacted with this hierarchical nanoscale skeleton, and MXene not only convolved on nanoscale fibrils to generate bumps but also MXene covered the end of broken fibrils to build spots, and furthermore, MXene adhered on the soft EOPO embedded EVOH fibrils to form wrinkles, in which these bumps, spots and wrinkles assembled by highly conductive 2D MXene offered sufficient contacts when the hierarchical nanoscale skeleton was compressed (these contacts would then destruct when the skeleton recovered). Such an elaborated hybrid nanostructural design exploits the full potential of 2D MXene and hence achieves an ultra-high sensitivity of 6895.0 kPa-1 for this fabricated MXene piezoresistive sensor.

Bio-based poly(lactic acid) foams with enhanced mechanical and heat-resistant properties obtained by facilitating stereocomplex crystallization with addition of D-sorbitol.

The preparation of bio-based poly(lactic acid) (PLA) foams with high mechanical properties and heat resistance is of great significance for environmental protection and green sustainable development. In this paper, D-sorbitol (DS) containing six hydroxyl groups was introduced into poly(l-lactide) (PLLA)/poly(d-lactide) (PDLA) blends for first time to promote the formation of stereocomplex (SC) crystals, which could improve the foaming behavior and enhance mechanical properties and heat resistance of PLA foams. The results showed that DS could improve the formation efficiency and crystallinity of SC crystals by enhancing the hydrogen bonding between the enantiomeric molecular chains. Furthermore, the compression modulus and interactions Vicat softening temperature of the PLLA/PDLA/DS blend foam increased about 854% and 16% compared to the pure PLLA foam, respectively. Besides, when the annealing process was introduced, the compression and heat resistance of the PLA foams increased further. This study provided a feasible strategy for the preparation of bio-based and biodegradable PLA foams with outstanding compressive and heat resistance properties.

Integrated Fibrous Iontronic Pressure Sensors with High Sensitivity and Reliability for Human Plantar Pressure and Gait Analysis.

Flexible sensing systems (FSSs) designed to measure plantar pressure can deliver instantaneous feedback on human movement and posture. This feedback is crucial not only for preventing and controlling diseases associated with abnormal plantar pressures but also for optimizing athletes' postures to minimize injuries. The development of an optimal plantar pressure sensor hinges on key metrics such as a wide sensing range, high sensitivity, and long-term stability. However, the effectiveness of current flexible sensors is impeded by numerous challenges, including limitations in structural deformability, mechanical incompatibility between multifunctional layers, and instability under complex stress conditions. Addressing these limitations, we have engineered an integrated pressure sensing system with high sensitivity and reliability for human plantar pressure and gait analysis. It features a high-modulus, porous laminated ionic fiber structure with robust self-bonded interfaces, utilizing a unified polyimide material system. This system showcases a high sensitivity (156.6 kPa-1), an extensive sensing range (up to 4000 kPa), and augmented interfacial toughness and durability (over 150,000 cycles). Additionally, our FSS is capable of real-time monitoring of plantar pressure distribution across various sports activities. Leveraging deep learning, the flexible sensing system achieves a high-precision, intelligent recognition of different plantar types with a 99.8% accuracy rate. This approach provides a strategic advancement in the field of flexible pressure sensors, ensuring prolonged stability and accuracy even amidst complex pressure dynamics and providing a feasible solution for long-term gait monitoring and analysis.

Surface Quality and Material Removal Rate in Fabricating Microtexture on Tungsten Carbide via Femtosecond Laser.

Tungsten carbide is currently the most widely used tool material for machining difficult-to-machine materials, such as titanium alloys and nickel-based super alloys. In order to improve the performance of tungsten carbide tools, surface microtexturing, a novel technology that can effectively reduce cutting forces and cutting temperatures and improve wear resistance, has been applied in metalworking processes. However, when fabricating the micro-textures such as micro-grooves or micro-holes on tool surfaces, the significant decrease in material removal rate is a major obstacle. In this study, a straight-groove-array microtexture was fabricated on the surface of tungsten carbide tools via a femtosecond laser with different machining parameters including laser power, laser frequency, and scanning speed. The material removal rate, surface roughness, and the laser-induced periodic surface structure were analyzed. It was found that the increase in the scanning speed decreased the material removal rate, whereas increasing the laser power and laser frequency had the opposite effects on the material removal rate. The laser-induced periodic surface structure was found to have a significant influence on the material removal rate, and the destruction of the laser-induced periodic surface structure was the reason for the reduction in the material removal rate. The results of the study revealed the fundamental mechanisms of the efficient machining method for the fabrication of microtextures on ultrahard materials with an ultrashort laser.

Green and effective fabrication of porous surfaces with adjustable cell structure by foaming at incomplete healed polymer-polymer interface.

Porous surfaces of materials have shown huge potentialities for endowing materials with multifarious functions. Despite introducing gas-confined-barriers in supercritical CO2 foaming technology is effective to weaken the gas escape effect and facilitate the preparation of porous surfaces, the differences in intrinsic properties between barriers and polymers result in bottlenecks like cell structure adjustment limitation and incompletely eliminated solid skin layers. This study undertakes a preparation approach for porous surfaces by foaming at incompletely healed polystyrene/polystyrene interfaces. In contrast with employing gas-confined-barriers reported before, the porous surfaces foamed at incompletely healed polymer/polymer interfaces show a monolayer, full-open cell morphology, and wide adjustable range in cell structures including cell size (120 nm∼15.68 µm), cell density (3.40 × 105 cells/cm2∼3.47 × 109 cells/cm2), and surface roughness (0.50 µm∼7.22 µm). Furthermore, the wettability of obtained porous surfaces depending on the cell structures is systematically discussed. Finally, a super-hydrophobic surface with hierarchical micro-nanoscale roughness, low water adhesion, and high water-impact resistance is built by depositing nanoparticles on a porous surface. Consequently, this study offers a clean and simple method to prepare porous surfaces with adjustable cell structures, which is expected to open a door to developing a new fabrication technique for micro/nano-porous surfaces.

The State of the Art in Machining Additively Manufactured Titanium Alloy Ti-6Al-4V.

Titanium alloys are extensively used in various industries due to their excellent corrosion resistance and outstanding mechanical properties. However, titanium alloys are difficult to machine due to their low thermal conductivity and high chemical reactivity with tool materials. In recent years, there has been increasing interest in the use of titanium components produced by additive manufacturing (AM) for a range of high-value applications in aerospace, biomedical, and automotive industries. The machining of additively manufactured titanium alloys presents additional machining challenges as the alloys exhibit unique properties compared to their wrought counterparts, including increased anisotropy, strength, and hardness. The associated higher cutting forces, higher temperatures, accelerated tool wear, and decreased machinability lead to an expensive and unsustainable machining process. The challenges in machining additively manufactured titanium alloys are not comprehensively documented in the literature, and this paper aims to address this limitation. A review is presented on the machining characteristics of titanium alloys produced by different AM techniques, focusing on the effects of anisotropy, porosity, and post-processing treatment of additively manufactured Ti-6Al-4V, the most commonly used AM titanium alloy. The mechanisms resulting in different machining performance and quality are analysed, including the influence of a hybrid manufacturing approach combining AM with conventional methods. Based on the review of the latest developments, a future outlook for machining additively manufactured titanium alloys is presented.