Detalhe da pesquisa
1.
Rational Modulation of the Induced-Fit Conformational Change for Slow-Onset Inhibition in Mycobacterium tuberculosis InhA.
Biochemistry
; 54(30): 4683-91, 2015 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26147157
2.
Mechanism of the intramolecular Claisen condensation reaction catalyzed by MenB, a crotonase superfamily member.
Biochemistry
; 50(44): 9532-44, 2011 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-21830810
3.
A structural and energetic model for the slow-onset inhibition of the Mycobacterium tuberculosis enoyl-ACP reductase InhA.
ACS Chem Biol
; 9(4): 986-93, 2014 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24527857
4.
Time-dependent diaryl ether inhibitors of InhA: structure-activity relationship studies of enzyme inhibition, antibacterial activity, and in vivo efficacy.
ChemMedChem
; 9(4): 776-91, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24616444
5.
CoA Adducts of 4-Oxo-4-Phenylbut-2-enoates: Inhibitors of MenB from the M. tuberculosis Menaquinone Biosynthesis Pathway.
ACS Med Chem Lett
; 2(11): 818-823, 2011 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-22267981
6.
High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis.
ACS Chem Biol
; 1(1): 43-53, 2006 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-17163639