Fabrication of a bionic compound eye on a curved surface by using a self-assembly technique.

Microlens arrays on curved surfaces are regarded as critical elements of bionic compound eyes (BCEs), which exhibit the comparative advantages of a wide field of view and tracking fast-moving objects. However, the fabrication of a curved microlens array is still challenging. Along these lines, in this work, a straightforward, rapid, and low-cost technique for the fabrication of curved microlens arrays is reported by using the self-assembly technique. A reactive ion etching process treated the surface of the curved polydimethylsiloxane (PDMS) substrate to generate a hydrophobic-hydrophilic pattern. Then, the curved microlens array can be realized by dewetting a liquid glue onto the substrate using the dip-coating method and followed by crosslinking. The proposed BCE structure consists of 2400 microlenses (400 - µm diameter and 440 - µm center distance) arranged in a hexagonal configuration on a curved PDMS surface (34 - mm diameter and 40.4 - mm curvature radius). A field-of-view of 50° was demonstrated, which has potential applications in various fields including imaging sensors, medical diagnostics, machine vision systems, and photodetectors.

Liquid crystal microlens array with positive and negative focal lengths based on a patterned electrode.

A liquid crystal microlens array (LCMLA) with positive and negative focal lengths based on a ring-array patterned electrodes is demonstrated. By carefully designing patterned electrodes with a circular electrode array area and outer ring electrode region area, the switching of the positive and negative lens effect can be easily achieved in a single cell. A positive lens effect appeared when the voltage was applied to the outer ring electrode region and the top substrate. The focal length changed from infinity to 1 mm as the voltage varied from 0 to 3Vrms. A negative lens effect occurred when the voltage was applied to the circular electrode array and the top substrate. The focal length varied from infinity to -1mm when the voltage changed from 0 to 2Vrms. The imaging properties of the LCMLA at different voltages are evaluated. Our LCMLA, with simple structure, low driving voltage, and good stability, has potential applications in optical communication, imaging processing, and displays.

Vari-focal liquid microlens array using an electrically responsive fluid actuated by a ring array patterned electrode.

A transparent fluid dibutyl adipate (DBA) is suitable for fabricating the adaptive lens due to its unique deformation under a direct current (DC) electric field. In this report, a DBA liquid microlens array (LMA) with a tunable focal length is demonstrated. A hydrophobic layer deposited in the ring array patterns on the electrode induced the formation of the DBA liquid microdroplets array self-assembly. The electronegative DBA liquid tends to move to the anode at a DC voltage. The proposed DBA LMA with a diameter of 100 µm can change its focal length from 0.92 to 1.42 mm when the voltage changes from 0 to 200 V. The response time is relatively fast (∼790m s). Due to the high optical transmittance (∼91%) and good thermal stability in the temperature range of -24.8-161.5∘C, our DBA LMA shows good focusing properties and has potential applications in the field of image processing, portable electronic devices, beam steering, ophthalmology, and 3D displays.

Unraveling pancreatic ductal adenocarcinoma immune prognostic signature through a naive B cell gene set.

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC), a leading cause of cancer mortality, has a complex pathogenesis involving various immune cells, including B cells and their subpopulations. Despite emerging research on the role of these cells within the tumor microenvironment (TME), the detailed molecular interactions with tumor-infiltrating immune cells (TIICs) are not fully understood. METHODS: We applied CIBERSORT to quantify TIICs and naive B cells, which are prognostic for PDAC. Marker genes from scRNA-seq and modular genes from weighted gene co-expression network analysis (WGCNA) were integrated to identify naive B cell-related genes. A prognostic signature was constructed utilizing ten machine-learning algorithms, with validation in external cohorts. We further assessed the immune cell diversity, ESTIMATE scores, and immune checkpoint genes (ICGs) between patient groups stratified by risk to clarify the immune landscape in PDAC. RESULTS: Our analysis identified 994 naive B cell-related genes across single-cell and bulk transcriptomes, with 247 linked to overall survival. We developed a 12-gene prognostic signature using Lasso and plsRcox algorithms, which was confirmed by 10-fold cross-validation and showed robust predictive power in training and real-world cohorts. Notably, we observed substantial differences in immune infiltration between patients with high and low risk. CONCLUSION: Our study presents a robust prognostic signature that effectively maps the complex immune interactions in PDAC, emphasizing the critical function of naive B cells and suggesting new avenues for immunotherapeutic interventions. This signature has potential clinical applications in personalizing PDAC treatment, enhancing the understanding of immune dynamics, and guiding immunotherapy strategies.

The Correlation Between Heart Failure and Gut Microbiome Metabolites.

Heart failure (HF) is a global public health problem, with morbidity and mortality increasing year by year. The gut microbiome actively affects the physiological and pathological activities of the human body in a variety of ways. More and more studies have suggested a strong correlation between HF and gut microbiome metabolites. Our review summarizes the specific alteration of these metabolites and their connection to the progression of HF, aiming at considering new approaches toward regulating the gut microbiome and using its metabolic pathways to treat HF, potentially decreasing the morbidity and mortality of HF as well as improving prognosis.