Detalhe da pesquisa
1.
Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors.
J Biol Chem
; 299(3): 102959, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36717078
2.
Structural Insights into the Interleukin-17 Family Cytokines and Their Receptors.
Adv Exp Med Biol
; 1172: 97-117, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31628653
3.
Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor.
J Am Chem Soc
; 139(9): 3528-3536, 2017 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28230359
4.
Crystal structure of a human IκB kinase ß asymmetric dimer.
J Biol Chem
; 288(31): 22758-67, 2013 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23792959
5.
Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations.
J Biol Chem
; 287(17): 13598-610, 2012 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22298776
6.
Biophysical and mechanistic insights into novel allosteric inhibitor of spleen tyrosine kinase.
J Biol Chem
; 287(10): 7717-27, 2012 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22219190
7.
Crystal structures of cholesteryl ester transfer protein in complex with inhibitors.
J Biol Chem
; 287(44): 37321-9, 2012 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22961980
8.
Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.
Bioorg Med Chem Lett
; 23(16): 4571-8, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23831135
9.
A covalent BTK ternary complex compatible with targeted protein degradation.
Nat Commun
; 14(1): 1189, 2023 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36864023
10.
Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13.
Nat Commun
; 14(1): 5158, 2023 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37620305
11.
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels.
Nat Commun
; 14(1): 4812, 2023 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37558654
12.
Affinity purification of a chimeric nicotinic acetylcholine receptor in the agonist and antagonist bound states.
Protein Expr Purif
; 79(1): 102-10, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21664975
13.
1-((3S,4S)-4-amino-1-(4-substituted-1,3,5-triazin-2-yl) pyrrolidin-3-yl)-5,5-difluoropiperidin-2-one inhibitors of DPP-4 for the treatment of type 2 diabetes.
Bioorg Med Chem Lett
; 21(6): 1810-4, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21324688
14.
Understanding the impact of the P-loop conformation on kinase selectivity.
J Chem Inf Model
; 51(6): 1199-204, 2011 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21568278
15.
Structural basis for the catalytic mechanism of human phosphodiesterase 9.
Proc Natl Acad Sci U S A
; 105(36): 13309-14, 2008 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-18757755
16.
(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor.
Bioorg Med Chem Lett
; 19(7): 1991-5, 2009 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19275964
17.
An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.
Structure
; 26(4): 533-544.e3, 2018 04 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29576321
18.
2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety.
J Med Chem
; 61(7): 3114-3125, 2018 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29570292
19.
Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies.
Nat Commun
; 8(1): 1908, 2017 12 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29199275
20.
Identification and Profiling of a Selective and Brain Penetrant Radioligand for in Vivo Target Occupancy Measurement of Casein Kinase 1 (CK1) Inhibitors.
ACS Chem Neurosci
; 8(9): 1995-2004, 2017 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28609096