Detalhe da pesquisa
1.
Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell
; 186(24): 5347-5362.e24, 2023 11 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37963465
2.
Target-based drug design strategies to overcome resistance to antiviral agents: opportunities and challenges.
Drug Resist Updat
; 73: 101053, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38301487
3.
Increased Siglec-9/Siglec-9L interactions on NK cells predict poor HCC prognosis and present a targetable checkpoint for immunotherapy.
J Hepatol
; 80(5): 792-804, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38331327
4.
High-Throughput Miniaturized Synthesis of PROTAC-Like Molecules.
Small
; : e2307215, 2024 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38258390
5.
Structure-based design of diarylpyrimidines and triarylpyrimidines as potent HIV-1 NNRTIs with improved metabolic stability and drug resistance profiles.
J Med Virol
; 96(3): e29502, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38450817
6.
Discovery of low-molecular-weight phenylalanine derivatives as novel HIV capsid modulators with improved antiretroviral activity and metabolic stability.
J Med Virol
; 96(4): e29594, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38576317
7.
Regulating Excited States by Varying Different Acceptors of D-π-A Emitters for Efficient Non-Doped Blue Electroluminescence with High Luminance and Low Efficiency Roll-Off.
Chemistry
; 30(8): e202303686, 2024 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38054967
8.
Discovery of ligustrazine and chalcone derivatives as novel viral nucleoprotein nuclear export inhibitors against influenza viruses.
J Med Virol
; 95(7): e28968, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37489704
9.
Identification of Ebselen derivatives as novel SARS-CoV-2 main protease inhibitors: Design, synthesis, biological evaluation, and structure-activity relationships exploration.
Bioorg Med Chem
; 96: 117531, 2023 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37972434
10.
Multifunctional agents against Alzheimer's disease based on oxidative stress: Polysubstituted pyrazine derivatives synthesized by multicomponent reactions.
Bioorg Med Chem
; 96: 117535, 2023 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37956505
11.
In situ click chemistry-based discovery of 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs by exploiting the tolerant region I in binding pocket.
Bioorg Med Chem
; 96: 117484, 2023 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37976805
12.
Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies.
Bioorg Chem
; 134: 106465, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36933339
13.
A novel N-heterocycles substituted oseltamivir derivatives as potent inhibitors of influenza virus neuraminidase: discovery, synthesis and biological evaluation.
J Enzyme Inhib Med Chem
; 38(1): 2277135, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37955306
14.
Longitudinal and Lateral Control Strategies for Automatic Lane Change to Avoid Collision in Vehicle High-Speed Driving.
Sensors (Basel)
; 23(11)2023 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37300028
15.
ABF1 Positively Regulates Rice Chilling Tolerance via Inducing Trehalose Biosynthesis.
Int J Mol Sci
; 24(13)2023 Jul 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37446259
16.
Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study.
Int J Mol Sci
; 24(2)2023 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36674730
17.
Icariin Promotes Osteogenic Differentiation in a Cell Model with NF1 Gene Knockout by Activating the cAMP/PKA/CREB Pathway.
Molecules
; 28(13)2023 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37446790
18.
Untangling microbiota diversity and assembly patterns in the world's longest underground culvert water diversion canal.
Environ Monit Assess
; 195(8): 981, 2023 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37480396
19.
Discovery of novel 1,2,4-triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein.
J Med Virol
; 94(12): 5975-5986, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35949003
20.
Indolylarylsulfones bearing phenylboronic acid and phenylboronate ester functionalities as potent HIV1 non-nucleoside reverse transcriptase inhibitors.
Bioorg Med Chem
; 53: 116531, 2022 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34890994