Detalhe da pesquisa
1.
Prediction of Human Clearance Using In Silico Models with Reduced Bias.
Mol Pharm
; 21(3): 1192-1203, 2024 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38285644
2.
The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.
Nature
; 543(7647): 733-737, 2017 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-28329763
3.
An Accurate In Vitro Prediction of Human VDss Based on the Øie-Tozer Equation and Primary Physicochemical Descriptors. 3. Analysis and Assessment of Predictivity on a Large Dataset.
Drug Metab Dispos
; 47(12): 1380-1387, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31578209
4.
Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds.
Drug Metab Dispos
; 46(11): 1466-1477, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30115648
5.
In Silico Prediction of Volume of Distribution in Humans. Extensive Data Set and the Exploration of Linear and Nonlinear Methods Coupled with Molecular Interaction Fields Descriptors.
J Chem Inf Model
; 56(10): 2042-2052, 2016 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-27602694
6.
Benefit of Retraining pKa Models Studied Using Internally Measured Data.
J Chem Inf Model
; 55(7): 1449-59, 2015 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26052622
7.
Flat patch mesh versus three-dimensional mesh (plug) for open umbilical or epigastric hernia repair. A retrospective study.
Ann Ital Chir
; 94: 512-517, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38051502
8.
Oxidative ipso substitution of 2,4-difluoro-benzylphthalazines: identification of a rare stable quinone methide and subsequent GSH conjugate.
Drug Metab Dispos
; 40(11): 2074-80, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22851614
9.
In silico prediction of total human plasma clearance.
J Chem Inf Model
; 52(8): 2069-78, 2012 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22715914
10.
In Silico Models of Human PK Parameters. Prediction of Volume of Distribution Using an Extensive Data Set and a Reduced Number of Parameters.
J Pharm Sci
; 110(1): 500-509, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32891631
11.
Use of the Øie-Tozer model in understanding mechanisms and determinants of drug distribution.
Drug Metab Dispos
; 38(7): 1159-65, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20375179
12.
Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders.
J Med Chem
; 63(3): 1068-1083, 2020 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31955578
13.
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug Metab Dispos
; 36(7): 1385-405, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18426954
14.
Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.
J Med Chem
; 61(7): 2837-2864, 2018 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29562737
15.
Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1.
J Med Chem
; 61(18): 8120-8135, 2018 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30137981
16.
In Silico Absorption, Distribution, Metabolism, Excretion, and Pharmacokinetics (ADME-PK): Utility and Best Practices. An Industry Perspective from the International Consortium for Innovation through Quality in Pharmaceutical Development.
J Med Chem
; 60(22): 9097-9113, 2017 11 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28609624
17.
Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer.
J Med Chem
; 60(7): 2790-2818, 2017 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28296398
18.
A hybrid mixture discriminant analysis-random forest computational model for the prediction of volume of distribution of drugs in human.
J Med Chem
; 49(7): 2262-7, 2006 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16570922
19.
Systematic Evaluation of Wajima Superposition (Steady-State Concentration to Mean Residence Time) in the Estimation of Human Intravenous Pharmacokinetic Profile.
J Pharm Sci
; 105(3): 1277-87, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26886320
20.
Antibacterial and Solubility Optimization of Thiomuracin A.
J Med Chem
; 59(14): 6920-8, 2016 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27355833