Detalhe da pesquisa
1.
Structure and Dynamics of the Flexible Cardiac Troponin T Linker Domain in a Fully Reconstituted Thin Filament.
Biochemistry
; 61(13): 1229-1242, 2022 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35696530
2.
FRET-based analysis of the cardiac troponin T linker region reveals the structural basis of the hypertrophic cardiomyopathy-causing Δ160E mutation.
J Biol Chem
; 294(40): 14634-14647, 2019 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31387947
3.
Chronic Calmodulin-Kinase II Activation Drives Disease Progression in Mutation-Specific Hypertrophic Cardiomyopathy.
Circulation
; 139(12): 1517-1529, 2019 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30586744
4.
Biophysical Derangements in Genetic Cardiomyopathies.
Heart Fail Clin
; 14(2): 147-159, 2018 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-29525644
5.
Clinically Divergent Mutation Effects on the Structure and Function of the Human Cardiac Tropomyosin Overlap.
Biochemistry
; 56(26): 3403-3413, 2017 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28603979
6.
The HCM - Linked Mutation Arg92Leu in TNNT2 Allosterically Alters the cTnC - cTnI Interface and Disrupts the PKA-mediated Regulation of Myofilament Relaxation.
bioRxiv
; 2023 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37503299
7.
Computational and biophysical determination of pathogenicity of variants of unknown significance in cardiac thin filament.
JCI Insight
; 6(23)2021 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34699384
8.
Proof of Principle that Molecular Modeling Followed by a Biophysical Experiment Can Develop Small Molecules that Restore Function to the Cardiac Thin Filament in the Presence of Cardiomyopathic Mutations.
ACS Omega
; 4(4): 6492-6501, 2019 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31342001
9.
Improvement in 3-month patient-reported gastrointestinal symptoms after conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium in renal transplant patients.
Transplantation
; 84(11): 1443-51, 2007 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18091520