Pesquisa | Portal de Pesquisa da BVS

1.

Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy.

Luoma, Adrienne M; Suo, Shengbao; Wang, Yifan; Gunasti, Lauren; Porter, Caroline B M; Nabilsi, Nancy; Tadros, Jenny; Ferretti, Andrew P; Liao, Sida; Gurer, Cagan; Chen, Yu-Hui; Criscitiello, Shana; Ricker, Cora A; Dionne, Danielle; Rozenblatt-Rosen, Orit; Uppaluri, Ravindra; Haddad, Robert I; Ashenberg, Orr; Regev, Aviv; Van Allen, Eliezer M; MacBeath, Gavin; Schoenfeld, Jonathan D; Wucherpfennig, Kai W.

Cell ; 185(16): 2918-2935.e29, 2022 08 04.

Artigo em Inglês | MEDLINE | ID: mdl-35803260

2.

Unbiased Screens Show CD8⁺ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein.

Ferretti, Andrew P; Kula, Tomasz; Wang, Yifan; Nguyen, Dalena M V; Weinheimer, Adam; Dunlap, Garrett S; Xu, Qikai; Nabilsi, Nancy; Perullo, Candace R; Cristofaro, Alexander W; Whitton, Holly J; Virbasius, Amy; Olivier, Kenneth J; Buckner, Lyndsey R; Alistar, Angela T; Whitman, Eric D; Bertino, Sarah A; Chattopadhyay, Shrikanta; MacBeath, Gavin.

Immunity ; 53(5): 1095-1107.e3, 2020 11 17.

Artigo em Inglês | MEDLINE | ID: mdl-33128877

3.

A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis.

Gujral, Taranjit S; Chan, Marina; Peshkin, Leonid; Sorger, Peter K; Kirschner, Marc W; MacBeath, Gavin.

Cell ; 159(4): 844-56, 2014 Nov 06.

Artigo em Inglês | MEDLINE | ID: mdl-25417160

4.

Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks.

Lee, Michael J; Ye, Albert S; Gardino, Alexandra K; Heijink, Anne Margriet; Sorger, Peter K; MacBeath, Gavin; Yaffe, Michael B.

Cell ; 149(4): 780-94, 2012 May 11.

Artigo em Inglês | MEDLINE | ID: mdl-22579283

5.

Phenotype, specificity and avidity of antitumour CD8⁺ T cells in melanoma.

Oliveira, Giacomo; Stromhaug, Kari; Klaeger, Susan; Kula, Tomasz; Frederick, Dennie T; Le, Phuong M; Forman, Juliet; Huang, Teddy; Li, Shuqiang; Zhang, Wandi; Xu, Qikai; Cieri, Nicoletta; Clauser, Karl R; Shukla, Sachet A; Neuberg, Donna; Justesen, Sune; MacBeath, Gavin; Carr, Steven A; Fritsch, Edward F; Hacohen, Nir; Sade-Feldman, Moshe; Livak, Kenneth J; Boland, Genevieve M; Ott, Patrick A; Keskin, Derin B; Wu, Catherine J.

Nature ; 596(7870): 119-125, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-34290406

6.

MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM.

Casaletto, Jessica B; Geddie, Melissa L; Abu-Yousif, Adnan O; Masson, Kristina; Fulgham, Aaron; Boudot, Antoine; Maiwald, Tim; Kearns, Jeffrey D; Kohli, Neeraj; Su, Stephen; Razlog, Maja; Raue, Andreas; Kalra, Ashish; Håkansson, Maria; Logan, Derek T; Welin, Martin; Chattopadhyay, Shrikanta; Harms, Brian D; Nielsen, Ulrik B; Schoeberl, Birgit; Lugovskoy, Alexey A; MacBeath, Gavin.

Proc Natl Acad Sci U S A ; 116(15): 7533-7542, 2019 04 09.

Artigo em Inglês | MEDLINE | ID: mdl-30898885

7.

Phase 1 dose escalation study of seribantumab (MM-121), an anti-HER3 monoclonal antibody, in patients with advanced solid tumors.

Denlinger, Crystal S; Keedy, Vicki L; Moyo, Victor; MacBeath, Gavin; Shapiro, Geoffrey I.

Invest New Drugs ; 39(6): 1604-1612, 2021 12.

Artigo em Inglês | MEDLINE | ID: mdl-34250553

8.

A phase 1 study combining the HER3 antibody seribantumab (MM-121) and cetuximab with and without irinotecan.

Cleary, James M; McRee, Autumn J; Shapiro, Geoffrey I; Tolaney, Sara M; O'Neil, Bert H; Kearns, Jeffrey D; Mathews, Sara; Nering, Rachel; MacBeath, Gavin; Czibere, Akos; Sharma, Sunil; Korn, W Michael.

Invest New Drugs ; 35(1): 68-78, 2017 02.

Artigo em Inglês | MEDLINE | ID: mdl-27853996

9.

Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins.

Yi, Chae-ryun; Allen, John E; Russo, Brian; Lee, Soo Young; Heindl, Jason E; Baxt, Leigh A; Herrera, Bobby Brooke; Kahoud, Emily; MacBeath, Gavin; Goldberg, Marcia B.

J Biol Chem ; 289(43): 30101-13, 2014 Oct 24.

Artigo em Inglês | MEDLINE | ID: mdl-25124035

10.

Heregulin and HER3 are prognostic biomarkers in oropharyngeal squamous cell carcinoma.

Qian, Guoqing; Jiang, Ning; Wang, Dongsheng; Newman, Scott; Kim, Sungjin; Chen, Zhengjia; Garcia, Gabriela; MacBeath, Gavin; Shin, Dong M; Khuri, Fadlo R; Chen, Zhuo G; Saba, Nabil F.

Cancer ; 121(20): 3600-11, 2015 Oct 15.

Artigo em Inglês | MEDLINE | ID: mdl-26195293

11.

Phosphotyrosine signaling proteins that drive oncogenesis tend to be highly interconnected.

Koytiger, Grigoriy; Kaushansky, Alexis; Gordus, Andrew; Rush, John; Sorger, Peter K; MacBeath, Gavin.

Mol Cell Proteomics ; 12(5): 1204-13, 2013 May.

Artigo em Inglês | MEDLINE | ID: mdl-23358503

12.

Single-cell quantitative HER2 measurement identifies heterogeneity and distinct subgroups within traditionally defined HER2-positive patients.

Onsum, Matthew D; Geretti, Elena; Paragas, Violette; Kudla, Arthur J; Moulis, Sharon P; Luus, Lia; Wickham, Thomas J; McDonagh, Charlotte F; MacBeath, Gavin; Hendriks, Bart S.

Am J Pathol ; 183(5): 1446-1460, 2013 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-24035511

13.

Cross-talk between receptor tyrosine kinase and tumor necrosis factor-α signaling networks regulates apoptosis but not proliferation.

Beyer, Elsa M; MacBeath, Gavin.

Mol Cell Proteomics ; 11(6): M111.013292, 2012 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-22323825

14.

Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements.

Boettcher, Jan Peter; Kirchner, Marieluise; Churin, Yuri; Kaushansky, Alexis; Pompaiah, Malvika; Thorn, Hans; Brinkmann, Volker; Macbeath, Gavin; Meyer, Thomas F.

PLoS Biol ; 8(8)2010 Aug 24.

Artigo em Inglês | MEDLINE | ID: mdl-20808760

15.

Lysate microarrays enable high-throughput, quantitative investigations of cellular signaling.

Sevecka, Mark; Wolf-Yadlin, Alejandro; MacBeath, Gavin.

Mol Cell Proteomics ; 10(4): M110.005363, 2011 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-21296872

16.

Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells.

Shalek, Alex K; Robinson, Jacob T; Karp, Ethan S; Lee, Jin Seok; Ahn, Dae-Ro; Yoon, Myung-Han; Sutton, Amy; Jorgolli, Marsela; Gertner, Rona S; Gujral, Taranjit S; MacBeath, Gavin; Yang, Eun Gyeong; Park, Hongkun.

Proc Natl Acad Sci U S A ; 107(5): 1870-5, 2010 Feb 02.

Artigo em Inglês | MEDLINE | ID: mdl-20080678

17.

Protein microarrays and proteomics.

MacBeath, Gavin.

Nat Genet ; 32 Suppl: 526-32, 2002 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-12454649

18.

A quantitative protein interaction network for the ErbB receptors using protein microarrays.

Jones, Richard B; Gordus, Andrew; Krall, Jordan A; MacBeath, Gavin.

Nature ; 439(7073): 168-74, 2006 Jan 12.

Artigo em Inglês | MEDLINE | ID: mdl-16273093

19.

Linear combinations of docking affinities explain quantitative differences in RTK signaling.

Gordus, Andrew; Krall, Jordan A; Beyer, Elsa M; Kaushansky, Alexis; Wolf-Yadlin, Alejandro; Sevecka, Mark; Chang, Bryan H; Rush, John; MacBeath, Gavin.

Mol Syst Biol ; 5: 235, 2009.

Artigo em Inglês | MEDLINE | ID: mdl-19156127

20.

System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties.

Kaushansky, Alexis; Gordus, Andrew; Budnik, Bogdan A; Lane, William S; Rush, John; MacBeath, Gavin.

Chem Biol ; 15(8): 808-17, 2008 Aug 25.

Artigo em Inglês | MEDLINE | ID: mdl-18721752

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