Detalhe da pesquisa
1.
Lung-restricted ALK5 inhibition avoids systemic toxicities associated with TGFß pathway inhibition.
Toxicol Appl Pharmacol
; 438: 115905, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35122773
2.
Identification of a functional antioxidant response element within the eighth intron of the human ABCC3 gene.
Drug Metab Dispos
; 43(1): 93-9, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25349122
3.
Using Genetically Modified Rodent Models in Drug Development to Explore Target Physiology and Potential Drug Effects.
Vet Pathol
; 55(2): 193-194, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29457566
4.
Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages.
Arch Biochem Biophys
; 508(1): 101-9, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21303654
5.
Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung.
Carcinogenesis
; 31(10): 1833-43, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20513672
6.
Atypical presentation and pathogenesis of a macaque lymphocryptoviral-associated B-cell lymphoma in a cynomolgus monkey.
Vet Clin Pathol
; 49(1): 130-136, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-32009251
7.
Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems.
Biochem Biophys Res Commun
; 389(3): 431-6, 2009 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-19732748
8.
BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress.
Mol Cell Biol
; 26(21): 7942-52, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16923960
9.
Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis.
Biochim Biophys Acta
; 1768(3): 637-47, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17141734
10.
Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway.
Hepatology
; 46(5): 1597-610, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17668877
11.
The Nrf2 activator oltipraz also activates the constitutive androstane receptor.
Drug Metab Dispos
; 36(8): 1716-21, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18474683
12.
Ischemia-reperfusion of rat livers decreases liver and increases kidney multidrug resistance associated protein 2 (Mrp2).
Toxicol Sci
; 101(1): 171-8, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17959626
13.
Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes.
Biochem J
; 404(3): 459-66, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17313370
14.
Hepatocyte-specific deletion of heme oxygenase-1 disrupts redox homeostasis in basal and oxidative environments.
Tohoku J Exp Med
; 216(4): 331-9, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19060448
15.
Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis.
Carcinogenesis
; 28(11): 2398-403, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17602169
16.
Kupffer cell-mediated downregulation of hepatic transporter expression in rat hepatic ischemia-reperfusion.
Transplantation
; 82(2): 258-66, 2006 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-16858290
17.
Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis.
Cell Stress Chaperones
; 11(4): 356-63, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-17278884
18.
Genetic analysis of cytoprotective functions supported by graded expression of Keap1.
Mol Cell Biol
; 30(12): 3016-26, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20404090
19.
Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid.
Toxicol Sci
; 106(2): 319-28, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18757529
20.
Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2.
Toxicol Appl Pharmacol
; 226(1): 74-83, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17935745