Detalhe da pesquisa
1.
Simultaneous evaluation of treatment efficacy and toxicity for bispecific T-cell engager therapeutics in a humanized mouse model.
FASEB J
; 37(6): e22995, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37219526
2.
Challenges and gaps in immunosafety evaluation of therapeutics: An IQ DruSafe survey.
Regul Toxicol Pharmacol
; 150: 105630, 2024 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38642729
3.
In vivo biodistribution and pharmacokinetics of sotrovimab, a SARS-CoV-2 monoclonal antibody, in healthy cynomolgus monkeys.
Eur J Nucl Med Mol Imaging
; 50(3): 667-678, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36305907
4.
Nonclinical safety assessment of engineered T cell therapies.
Regul Toxicol Pharmacol
; 127: 105064, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34656748
5.
Industry experiences with immune-mediated findings in biotherapeutic nonclinical toxicology studies.
Regul Toxicol Pharmacol
; 119: 104825, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33220389
6.
Developing a framework for assessing chemical respiratory sensitization: A workshop report.
Regul Toxicol Pharmacol
; 80: 295-309, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27396307
7.
Consensus on the Key Characteristics of Immunotoxic Agents as a Basis for Hazard Identification.
Environ Health Perspect
; 130(10): 105001, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36201310
8.
Modulation of Kv channel expression and function by TCR and costimulatory signals during peripheral CD4(+) lymphocyte differentiation.
J Exp Med
; 196(7): 897-909, 2002 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-12370252
9.
Immune complex disease in a chronic monkey study with a humanised, therapeutic antibody against CCL20 is associated with complement-containing drug aggregates.
PLoS One
; 15(4): e0231655, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32325480
10.
Immunogenicity of biologically-derived therapeutics: assessment and interpretation of nonclinical safety studies.
Regul Toxicol Pharmacol
; 54(2): 164-82, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19345250
11.
Challenges and opportunities for the future of monoclonal antibody development: Improving safety assessment and reducing animal use.
MAbs
; 9(5): 742-755, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28475417
12.
Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses.
Adv Drug Deliv Rev
; 71: 15-33, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24530633
13.
Assessing a theoretical risk of dolutegravir-induced developmental immunotoxicity in juvenile rats.
Toxicol Sci
; 130(1): 70-81, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22790968
14.
High-dose recombinant interleukin-18 induces an effective Th1 immune response to murine MOPC-315 plasmacytoma.
J Immunother
; 25 Suppl 1: S20-7, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12048347
15.
Immunopharmacology of recombinant human interleukin-18 in non-human primates.
Cytokine
; 20(1): 38-48, 2002 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-12441145