Detalhe da pesquisa
1.
Small-molecule IKKß activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth.
Proc Natl Acad Sci U S A
; 119(18): e2115071119, 2022 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35476515
2.
Spirocyclic dimer SpiD7 activates the unfolded protein response to selectively inhibit growth and induce apoptosis of cancer cells.
J Biol Chem
; 298(5): 101890, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35378132
3.
Dimers of isatin derived α-methylene-γ-butyrolactone as potent anti-cancer agents.
Bioorg Med Chem Lett
; 65: 128713, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35367592
4.
Aminopyrazole based CDK9 PROTAC sensitizes pancreatic cancer cells to venetoclax.
Bioorg Med Chem Lett
; 43: 128061, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33895280
5.
DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation.
bioRxiv
; 2024 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37066260
6.
Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects.
Cancer Res Commun
; 4(5): 1328-1343, 2024 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38687198
7.
Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding.
RSC Med Chem
; 14(5): 921-933, 2023 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37252106
8.
Stapling proteins in the RELA complex inhibits TNFα-induced nuclear translocation of RELA.
RSC Chem Biol
; 3(1): 32-36, 2022 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35128406
9.
Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior.
Front Pharmacol
; 13: 863762, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35645825
10.
Inhibitors, PROTACs and Molecular Glues as Diverse Therapeutic Modalities to Target Cyclin-Dependent Kinase.
Cancers (Basel)
; 13(21)2021 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34771669
11.
Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKß phosphorylation for pancreatic cancer therapy.
Eur J Med Chem
; 222: 113579, 2021 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34098465
12.
Identification of potential binding pocket on viral oncoprotein HPV16 E6: a promising anti-cancer target for small molecule drug discovery.
BMC Mol Cell Biol
; 20(1): 30, 2019 08 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31387520
13.
Recent advances in the discovery of small-molecule inhibitors of HIV-1 integrase.
Future Sci OA
; 4(9): FSO338, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-30416746
14.
Selective CDK9 degradation using a proteolysis-targeting chimera (PROTAC) strategy.
Future Med Chem
; 14(3): 131-134, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34814708
15.
Synthesis and binding characteristics of [(3)H]neuromedin N, a NTS2 receptor ligand.
Neuropeptides
; 57: 15-20, 2016 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26707235
16.
Synthesis and pharmacological evaluation of [(3)H]HS665, a novel, highly selective radioligand for the kappa opioid receptor.
ACS Chem Neurosci
; 6(3): 456-63, 2015 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25496417
17.
In vitro pharmacological evaluation of the radiolabeled C-terminal substance P analogue Lys-Phe-Phe-Gly-Leu-Met-NH2: Does a specific binding site exist?
Folia Neuropathol
; 52(4): 383-9, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25574743
18.
Tritiated opioid receptor ligands as radiotracers.
Curr Pharm Des
; 19(42): 7461-72, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23448471
19.
[3H]IVDE77, a novel radioligand with high affinity and selectivity for the insulin-regulated aminopeptidase.
Eur J Pharmacol
; 702(1-3): 93-102, 2013 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23376157
20.
Stereoselective analysis of endomorphin diastereomers: resolution of biologically active analogues by capillary electrophoresis applying cyclodextrins as mobile phase additives.
J Pharm Biomed Anal
; 70: 32-9, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22677655