Detalhe da pesquisa
1.
Dual Stromal Targeting Sensitizes Pancreatic Adenocarcinoma for Anti-Programmed Cell Death Protein 1 Therapy.
Gastroenterology
; 163(5): 1267-1280.e7, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35718227
2.
A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Recombinant Human Hyaluronidase PH20 Administered Intravenously in Healthy Volunteers.
Curr Ther Res Clin Exp
; 93: 100604, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32963641
3.
Phase 1 trials of PEGylated recombinant human hyaluronidase PH20 in patients with advanced solid tumours.
Br J Cancer
; 118(2): 153-161, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28949957
4.
Phase 1 trials of PEGylated recombinant human hyaluronidase PH20 in patients with advanced solid tumours.
Br J Cancer
; 118(2): e3, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29361630
5.
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer.
Gut
; 62(1): 112-20, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22466618
6.
Phase I trial of intravesical recombinant adenovirus mediated interferon-α2b formulated in Syn3 for Bacillus Calmette-Guérin failures in nonmuscle invasive bladder cancer.
J Urol
; 190(3): 850-6, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23507396
7.
JNTX-101, a novel albumin-encapsulated gemcitabine prodrug, is efficacious and operates via caveolin-1-mediated endocytosis.
Mol Ther Oncolytics
; 30: 181-192, 2023 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37674628
8.
Risk Factors, Hyaluronidase Expression, and Clinical Immunogenicity of Recombinant Human Hyaluronidase PH20, an Enzyme Enabling Subcutaneous Drug Administration.
AAPS J
; 24(6): 110, 2022 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36266598
9.
Safety and pharmacokinetics of docetaxel in combination with pegvorhyaluronidase alfa in patients with non-small cell lung cancer.
Clin Transl Sci
; 14(5): 1875-1885, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33982408
10.
ENHANZE® drug delivery technology: a novel approach to subcutaneous administration using recombinant human hyaluronidase PH20
Drug Deliv
; 26(1): 98-106, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30744432
11.
The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44.
Oncotarget
; 10(61): 6561-6576, 2019 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31762938
12.
Parallel Accumulation of Tumor Hyaluronan, Collagen, and Other Drivers of Tumor Progression.
Clin Cancer Res
; 24(19): 4798-4807, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30084839
13.
PH20 is not expressed in murine CNS and oligodendrocyte precursor cells.
Ann Clin Transl Neurol
; 4(3): 191-211, 2017 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-28275653
14.
Successful adenovirus-mediated wild-type p53 gene transfer in patients with bladder cancer by intravesical vector instillation.
J Clin Oncol
; 20(4): 957-65, 2002 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-11844817
15.
Impact of human neutralizing antibodies on antitumor efficacy of an oncolytic adenovirus in a murine model.
Clin Cancer Res
; 10(21): 7199-206, 2004 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15534093
16.
Intra-arterial delivery of p53-containing adenoviral vector into experimental brain tumors.
Cancer Gene Ther
; 9(3): 228-35, 2002 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-11896438
17.
Syn3 provides high levels of intravesical adenoviral-mediated gene transfer for gene therapy of genetically altered urothelium and superficial bladder cancer.
Cancer Gene Ther
; 9(8): 687-91, 2002 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12136430
18.
p21WAF-1/Cip-1 gene therapy as an adjunct to glaucoma filtration surgery.
Curr Opin Mol Ther
; 6(6): 624-8, 2004 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-15663327
19.
Tolerability and pharmacokinetic properties of ondansetron administered subcutaneously with recombinant human hyaluronidase in minipigs and healthy volunteers.
Clin Ther
; 36(2): 211-24, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24486335
20.
Sustained intravesical interferon protein exposure is achieved using an adenoviral-mediated gene delivery system: a study in rats evaluating dosing regimens.
Urology
; 66(1): 224-9, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15992886