Detalhe da pesquisa
1.
Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect.
Mol Cell
; 59(3): 491-501, 2015 Aug 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26253029
2.
Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two phase 1 studies.
Lancet
; 396(10266): 1885-1894, 2020 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33308471
3.
Na(+)/H(+) antiporter (NHE1) and lactate/H(+) symporters (MCTs) in pH homeostasis and cancer metabolism.
Biochim Biophys Acta
; 1863(10): 2465-80, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26944480
4.
Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.
J Enzyme Inhib Med Chem
; 30(5): 689-721, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25347767
5.
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.
Proc Natl Acad Sci U S A
; 108(40): 16663-8, 2011 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21930917
6.
Mechanistic Modeling of the Interplay Between Host Immune System, IL-7 and UCART19 Allogeneic CAR-T Cells in Adult B-cell Acute Lymphoblastic Leukemia.
Cancer Res Commun
; 2(11): 1532-1544, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36970053
7.
Clinical Pharmacology and Determinants of Response to UCART19, an Allogeneic Anti-CD19 CAR-T Cell Product, in Adult B-cell Acute Lymphoblastic Leukemia.
Cancer Res Commun
; 2(11): 1520-1531, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36970059
8.
UCART19, a first-in-class allogeneic anti-CD19 chimeric antigen receptor T-cell therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia (CALM): a phase 1, dose-escalation trial.
Lancet Haematol
; 9(11): e833-e843, 2022 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-36228643
9.
Time 2EVOLVE: predicting efficacy of engineered T-cells - how far is the bench from the bedside?
J Immunother Cancer
; 10(5)2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35577501
10.
Time to evolve: predicting engineered T cell-associated toxicity with next-generation models.
J Immunother Cancer
; 10(5)2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35577500
11.
Optimized Protocol for the In Situ Derivatization of Glutathione with N-Ethylmaleimide in Cultured Cells and the Simultaneous Determination of Glutathione/Glutathione Disulfide Ratio by HPLC-UV-QTOF-MS.
Metabolites
; 10(7)2020 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32709039
12.
Disrupting the 'Warburg effect' re-routes cancer cells to OXPHOS offering a vulnerability point via 'ferroptosis'-induced cell death.
Adv Biol Regul
; 68: 55-63, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29306548
13.
Metabolic Plasiticy in Cancers-Distinct Role of Glycolytic Enzymes GPI, LDHs or Membrane Transporters MCTs.
Front Oncol
; 7: 313, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29326883
14.
Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters.
J Mol Med (Berl)
; 94(2): 155-71, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26099350
15.
Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export.
Mol Aspects Med
; 47-48: 3-14, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26724171
16.
Genetic disruption of lactate/H+ symporters (MCTs) and their subunit CD147/BASIGIN sensitizes glycolytic tumor cells to phenformin.
Cancer Res
; 75(1): 171-80, 2015 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25403912
17.
Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction.
Oncotarget
; 6(28): 24636-48, 2015 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26284589
18.
Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status.
Oncotarget
; 6(9): 6708-21, 2015 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-25894929
19.
Gene disruption using zinc finger nuclease technology.
Methods Mol Biol
; 1165: 253-60, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24839030