Neuroanatomical correlates of macrostructural receptive abilities in narrative discourse in unilateral left hemisphere stroke: A behavioural and voxel-based morphometry study.

BACKGROUND: Little is known about story retelling and comprehension abilities in groups with lower levels of education and socio-economic status (SES). A growing body of evidence suggests the role of an extended network supporting narrative comprehension, but few studies have been conducted in clinical populations, even less in developing countries. AIMS: To extend our knowledge of the impact of a stroke on macrostructural aspects of discourse processes, namely main and complementary information, in individuals with middle-low to low SES and low levels of education. Relationships were tested between the performance in story retell and comprehension and reading and writing habits (RWH). Also, the associations between retelling and comprehension measures and their structural grey matter (GM) correlates were explored. METHODS & PROCEDURES: A total of 17 adults with unilateral left hemisphere (LH) chronic ischaemic stroke without the presence of significant aphasia and 10 matched (age, education and SES) healthy controls (HC) participated in the study. Retell and comprehension tasks were performed after listening or reading narrative stories. Voxel-based morphometry (VBM) analysis was conducted on a subgroup of nine individuals with LH stroke and the 10 matched controls using structural magnetic resonance imaging (MRI). OUTCOMES & RESULTS: Retelling and comprehension abilities were not significantly different between LH and HC, nonetheless quantitively lower in LH. Exploratory correlations showed that retelling and comprehension abilities in both written and auditory modalities were correlated with naming abilities. At the neural level, written comprehension positively correlated with GM density of the LH, including areas in the temporal pole, superior and middle temporal gyrus as well as the orbitofrontal cortex, precentral and postcentral gyri. Auditory narrative comprehension was associated with GM density of the lingual gyrus in the right hemisphere. CONCLUSIONS & IMPLICATIONS: The present results suggest that retelling and comprehension of auditory and written narratives are relatively well-preserved in individuals with a LH stroke without significant aphasia, but poorer than in HC. The findings replicate previous studies conducted in groups with higher levels of education and SES both at the behavioural and neural levels. Considering that naming seems to be associated with narrative retell and comprehension in individuals with lower SES and education, this research provides evidence on the importance of pursuing further studies including larger samples with and without aphasia as well as with various SES and education levels. WHAT THIS PAPER ADDS: What is already known on this subject Story retell and comprehension of auditory and written discourse have been shown to be affected after stroke, but most studies have been conducted on individuals with middle to high SES and high educational levels. What this paper adds to existing knowledge The study reports on narrative retell and comprehension in both auditory and written modalities in groups of HC and individuals with LH brain damage, with low-to-middle SES and lower levels of education. What are the potential or actual clinical implications of this work? This study highlights the importance of taking into consideration the sociodemographic and RWH of patients when assessing discourse retell and comprehension in both auditory and written modalities. It also underlines the importance of including patients without significant aphasia following LH stroke to look at the effect of both stroke and aphasia on narrative comprehension and story retelling.

Posterior Reversible Encephalopathy Syndrome: Clinical Differences in Patients with Exclusive Involvement of Posterior Circulation Compared to Anterior or Global Involvement.

INTRODUCTION: Posterior reversible encephalopathy syndrome (PRES) is a clinical-radiologic syndrome not yet fully understood and characterized by transient neurologic symptoms in addition to typical radiological findings. There are only a few articles that describe the clinical differences between patients with PRES that involve carotid and vertebrobasilar circulations. Our study aims to further evaluate the differences between predominantly anterior and posterior circulation PRES. METHODS: We review 54 patients who had received the diagnosis of PRES from 2009 to 2015. The patients were divided into 2 groups: (1) exclusively in posterior zones; and (2) anterior plus posterior zones or exclusively anterior zones. Several clinical characteristics were evaluated, including the following: age, sex, previous diseases, the neurologic manifestations, the highest blood pressure in the first 48 hours of presentation, highest creatinine level during symptoms, and the neuroimaging alterations in brain magnetic resonance imaging. RESULTS: Mean age at diagnosis was 28.5 years old (9 men and 45 women) and mean systolic blood pressure among patients with lesions only in posterior zones was 162.1 mmHg compared to 179.2 mmHg in the anterior circulation. The most common symptoms in the 2 groups were headache and visual disturbances. DISCUSSION: PRES may have several radiological features. A higher blood pressure seems to be 1 of the factors responsible for developing widespread PRES, with involvement of carotid vascular territory. This clinical-radiological difference probably occurs because of the larger number of autonomic receptors in the carotid artery in comparison to the vertebral-basilar system.

Ocular myositis: insights into recurrence and semiological presentation.

Ocular myositis (OM) is a rare clinical entity characterized by idiopathic, nonspecific inflammation of primarily or exclusively extraocular muscles (EOM). Presentation usually encompasses painful diplopia, exacerbated by eye movement. We report two cases of idiopathic OM with unique characteristics. The first presented with pseudo-sixth nerve palsy due to medial nucleus inflammation and the second presented with recurrent OM, subsequently affecting both eyes. Knowledge of different patterns of presentation and recurrence are important to manage this rare inflammatory syndrome.

Macrostructural Aspects in Oral Narratives in Brazilian Portuguese by Left and Right Hemisphere Stroke Patients With Low Education and Low Socioeconomic Status.

OBJECTIVE: Individuals with a stroke in either the left hemisphere (LH) or the right hemisphere (RH) often present macrostructural impairments in narrative abilities. Understanding the potential influence of low education and low socioeconomic status (SES) is critical to a more effective assessment of poststroke language. The first aim was to investigate macrostructural processing in low-education and low-SES individuals with stroke in the LH or RH or without brain damage. The second aim was to verify the relationships between macrolinguistic, neuropsychological, and sociodemographic variables. METHOD: Forty-seven adults with LH (n = 15) or RH (n = 16) chronic ischemic stroke and 16 matched (age, education, and SES) healthy controls produced three oral picture-sequence narratives. The macrostructural aspects analyzed were cohesion, coherence, narrativity, macropropositions, and index of lexical informativeness and were compared among the three groups. Then, exploratory correlations were performed to assess associations between sociodemographic (such as SES), neuropsychological, and macrostructural variables. RESULTS: Both the LH and the RH presented impairments in the local macrostructural aspect (cohesion), whereas the RH also presented impairments in more global aspects (global coherence and macropropositions). All five macrostructural variables correlated with each other, with higher correlations with narrativity. Naming was correlated with all macrostructural variables, as well as prestroke reading and writing habits (RWH), showing that higher naming accuracy and higher RWH are associated with better macrostructural skills. CONCLUSIONS: The present results corroborate the role of the LH in more local processing and that of the RH in more global aspects of discourse. Moreover, this study highlights the importance of investigating discourse processing in healthy and clinical populations of understudied languages such as Brazilian Portuguese, with various levels of education, SES, and RWH.

Neuroanatomical Correlates of Macrolinguistic Aspects in Narrative Discourse in Unilateral Left and Right Hemisphere Stroke: A Voxel-Based Morphometry Study.

Background A growing body of literature has demonstrated the importance of discourse assessment in patients who suffered from brain injury, both in the left and right hemispheres, as discourse represents a key component of functional communication. However, little is known about the relationship between gray matter density and macrolinguistic processing. Purpose This study aimed to investigate this relationship in a group of participants with middle-low to low socioeconomic status. Method Twenty adults with unilateral left hemisphere (n = 10) or right hemisphere (n = 10) chronic ischemic stroke and 10 matched (age, education, and socioeconomic status) healthy controls produced three oral narratives based on sequential scenes. Voxel-based morphometry analysis was conducted using structural magnetic resonance imaging. Results Compared to healthy controls, the left hemisphere group showed cohesion impairments, whereas the right hemisphere group showed impairments in coherence and in producing macropropositions. Cohesion positively correlated with gray matter density in the right primary sensory area (PSA)/precentral gyrus and the pars opercularis. Coherence, narrativity, and index of lexical informativeness were positively associated with the left PSA/insula and the superior temporal gyrus. Macropropositions were mostly related to the left PSA/insula and superior temporal gyrus, left cingulate, and right primary motor area/insula. Discussion Overall, the present results suggest that both hemispheres are implicated in macrolinguistic processes in narrative discourse. Further studies including larger samples and with various socioeconomic status should be conducted. Supplemental Material https://doi.org/10.23641/asha.14347550.

Posterior reversible encephalopathy syndrome (PRES): Is DWI a prognosis factor?

INTRODUCTION: Posterior reversible encephalopathy syndrome is a clinicoradiologic entity with typical MR imaging showing a white matter vasogenic edema predominantly affecting the occipital and parietal lobes of the brain. The aim of this article is evaluated the importance of DWI as a prognosis factor in patients with PRES. MATERIALS AND METHODS: We reviewed data from 70 patients with PRES (35 with restricted DWI and 35 with no DWI abnormalities), that were admitted to Hospital São Lucas-PUCRS. These two groups were evaluated in age, sex, previous diseases and past medical history, use of medications, the neurologic manifestations, the highest blood pressure during the neurologic presentation and the highest creatinine during the period of observation. RESULTS: Evaluating 70 patients with PRES with a mean age of 25.4 years old (range from 2 to 74 years old; 55 female and 15 male) we identified 35 cases were brain MRI presents with restricted DWI. Restricted DWI was associated with higher mortality in 90 days (14.2% vs 0.0%; p: 0.027). CONCLUSIONS: Few articles present new data that will help clinicians in therapeutic decisions or that modify the knowledge of this syndrome. We suggested that restricted DWI is associated with a worst prognosis in PRES.

Vulnerabilidade e envelhecimento humano, conceitos e contextos: uma revisão / Vulnerability and human aging, concepts and contexts: a review

O presente artigo trata-se de uma revisão integrativa de literatura, cujo objetivo central é discutir o conceito de vulnerabilidade e descrever os estudos acerca da temática vulnerabilidade e envelhecimento humano. Foram realizadas buscas nas plataformas CAPES, BVS e PUBMED, utilizando os descritores, vulnerability study, aged, older person, older people, durante o período de janeiro a março de 2019. Utilizou-se 27 publicações para a confecção do presente artigo, organizadas em cinco temáticas distintas: conceito de vulnerabilidade; estudos sobre percepção/significado de vulnerabilidade; estudos teóricos sobre vulnerabilidade; ferramentas e índices de vulnerabilidade; estudos empíricos de prevalência e fatores associados à vulnerabilidade. A literatura dispõe diferentes conceitos para os diferentes contextos aplicáveis à vulnerabilidade. Para o idoso, quase sempre vulnerabilidade está relacionada a incapacidades físicas e dependência. Existem diversas publicações destinadas a adaptar e validar instrumentos. Foram levantados diversos fatores associados à vulnerabilidade, dentre os quais destacaram-se a incapacidade funcional, as doenças crônicas e a depressão.(AU)

This article is an integrative literature review, whose central objective is to discuss the concept of vulnerability and describe studies on the theme of vulnerability and human aging. Searches were carried out on the CAPES, BVS, and PUBMED platforms, using the descriptors, "vulnerability study", "aged", "older person", "older people", from January to March 2019. 27 publications were used for the making of this article, organized into five different themes: the concept of vulner- ability; studies on the perception/meaning of vulnerability; theoretical studies on vulnerability; tools and vulnerability indexes; and empirical studies of prevalence and factors associated with vulnerability. Th literature provides different concepts for the different application contexts of vulnerability. For the elderly, vulnerability is almost always related to physical disabilities and dependence. There are several publications aimed at adapting and validating instruments. Several factors associated with vulnerability were raised, among which, functional disability, chronic diseases, and depression stood out.(AU)

Reversible hemianopsia in postpartum due to posterior reversible encephalopathy syndrome in pregnant with late eclampsia. / Caso de hemianopsia reversível no pós-parto decorrente de síndrome da encefalopatia reversível posterior (PRES) em gestante com eclâmpsia tardia.

OBJECTIVES: To describe a case of Posterior Reversible Encephalopathy Syndrome diagnosed in pregnant women with late-eclampsia, as well as its clinical management. CASE DESCRIPTION: A 34 years old patient in her third pregnancy had started with high blood pressure levels during labor; after eleven days postpartum, she presented a decreased right visual acuity; subsequently one episode of seizure followed by partial loss of vision in the right eye. After conducting tests and ruled out stroke, the patient was diagnosed as Posterior Reversible Encephalopathy Syndrome (PRES). Established the clinical management of seizures and hypertensive crisis, there was complete remission of symptoms and reversal of the initial clinical picture. CONCLUSION: Once properly diagnosed and treated, the Posterior Reversible Encephalopathy Syndrome can present satisfactory progress, especially when associated with an acutely triggered factor, as eclampsia.

Holmes' tremor as a delayed complication of thalamic stroke.

Movement disorders are not commonly associated with stroke. Accordingly, thalamic strokes have rarely been associated with tremor, pseudo-athetosis and dystonic postures. We present a 75-year-old man who developed a disabling tremor 1 year after a posterolateral thalamic stroke. This tremor had low frequency (3-4 Hz), did not disappear on focus and was exacerbated by maintaining a static posture and on target pursuit, which made it very difficult to perform basic functions. MRI demonstrated an old ischemic lesion at the left posterolateral thalamus. Treatment with levodopa led to symptom control. Lesions in the midbrain, cerebellum and thalamus may cause Holmes' tremor. Delayed onset of symptoms is usually seen, sometimes appearing 2 years after the original injury. This may be due to maturation of a complex neuronal network, leading to slow dopaminergic denervation. Further studies are needed to improve our understanding of this unique disconnection syndrome.

Associação entre classes funcionais da insuficiência cardíaca com fração de ejeção preservada e comprometimento cognitivo / Association between the functional classification of heart failure with preserved fraction ejection and cognitive impairment

INTRODUÇÃO: A insuficiência cardíaca (IC) é uma síndrome resultante de defeitos estruturais e funcionais da bomba cardíaca, mais de 80% dos pacientes são idosos, com diversas comorbidades associadas. A demência é definida por qualquer desordem onde o declínio significativo do nível prévio de cognição do paciente interfere em sua independência e funcionamento social, doméstico ou ocupacional. A relação entre o comprometimento cognitivo leve e a IC já é bem estabelecida na literatura, porém estudos recentes apontam uma possível relação da IC na patogênese e no agravo da demência. OBJETIVOS: Classificar a limitação funcional de voluntários com IC com fração de ejeção preservada (FEp) e realizar o teste Montreal Cognitive Assessment (MoCA) de memória para analisar se há associação entre as limitações funcionais da IC e o deterioramento cognitivo do paciente. MÉTODOS: Trata-se de um estudo observacional transversal, foram avaliados 27 pacientes com história de ICFEp no ambulatório de Insuficiência Cardíaca do Hospital da Universidade Luterana do Brasil. RESULTADOS: Foram avaliados 27 pacientes, com idade média de 72.4 anos, sendo 18 (66.6%) do sexo feminino, 24 (88.8%) obtiveram escore no MoCA inferior a 26, sendo a média da escala 20.4. Entre os 27 pacientes, quatro apresentavam classe funcional NYHA I, 15 NYHA II, 3 NYHA III e 5 NYHA IV. CONCLUSÃO: O estudo mostra uma tendência de pior desempenho no MoCA entre pacientes com pior classe funcional de IC (NYHA I-II: MoCA 21.4 +/- 4.9 e NYHA III-IV MoCA: 18 +/- 4.2 p:0. 0.087)

INTRODUCTION: Heart failure (HF) is a syndrome resulting from structural and functional defects of cardiac pump, more than 80% of the patients are elderly with diverse associated comorbidities. The dementia is defined by any disorder where the significant decline of the previous cognition level of the patient intervene on his independence and social, domestic or occupational functioning. The link between light cognitive impairment and HF is already well documented in literature, however recent studies point a possible relation of HF in pathogenesis and deteriorating of dementia. OBJETIVE: Rank functional limitation of volunteers with HF with preserved ejection fraction and to apply the Montreal Cognitive Assessment (MoCA) memory test to analyse if there is a association between HF functional limitations and dementia onset/worsening. METHODS: Transversal observational study, 27 patients with HF with preserved ejection fraction were assessed in Universidade Luterana do Brasil's heart failure clinic. RESULTS: Assessing 27 patients, with average age of 72.4 years (+/-7.3), being 18 (66.6%) female, we found 24 (88.8%) with MoCA score lower to 26, being the average score 20.4. Between the 27 patients, 4 had functional class NYHA I, 15 NYHA II, 3 NYHA III and 5 NYHA IV. CONCLUSION: The present study shows a tendency to lower performance in MoCA on patients with worse HF functional classification (NYHA I-II: MoCA 21.4 +/- 4.9 e NYHA III-IV MoCA: 18 +/- 4.2 p:0. 0.087)

Traumatic Dissection of Arterial Cervical Vessels: Report of Two Cases and Literature Review

Even though traumatic dissection of cervical arterial vessels is themajor cause of stroke among adults, it is still an underdiagnosed disease in neurosurgical emergencies, since most patients do not have or present subtle clinical signs in the acute phase. The authors report two interesting cases of cervical artery dissection with different traumatic mechanisms and present a broad literature review about this subject.

Independência funcional após acidente vascular cerebral (AVC) isquêmico em relação à fisiopatologia de acordo com TOAST / Functional independence after ischemic stroke in relation to pathophysiology according to TOAST

FUNDAMENTO: O Acidente Vascular Cerebral é uma das principais causas de morte no Brasil. O conhecimento sobre a etiologia do AVC é fundamental para uma adequada abordagem dessa doença. OBJETIVO: Avaliar se existe relação entre o subtipo de AVC isquêmico com o prognóstico dele e os fatores de risco. MÉTODOS: Foram avaliados 86 casos de AVC isquêmico no Ambulatório de Neurologia do Hospital Universitário da cidade de Canoas-RS, no período de outubro de 2018 a novembro de 2019. Foi analisada a relação do prognóstico (mRankinS) com fatores de risco de AVC e TOAST. RESULTADOS: Avaliando 86 pacientes com 60.5 (±10.1) anos (40 homens), identificamos que oclusão de pequenos vasos apresentou melhor prognóstico (p: 0.031) e cardioembolia um pior prognóstico de acordo com mRankinS (p< 0.001). Diabetes mellitus também apresentou um pior prognóstico (p: 0.021). CONCLUSÃO: Pacientes com AVC isquêmico secundário a oclusão de pequenos vasos apresentam melhor prognóstico de acordo com mRs. Mecanismos cardioembólicos e a presença de DM estão associados com o pior prognóstico neurológico

BACKGROUND: Stroke is one of the main causes of death in Brazil. Knowledge about the etiology of stroke is essential for an adequate approach to this disease. OBJECTIVE: To assess whether there is a relationship between the ischemic stroke subtype and its prognosis and risk factors. METHODS: 86 cases of ischemic stroke were evaluated at the Neurology Outpatient Clinic of the University Hospital in the city of Canoas-RS, from October 2018 to November 2019. The relationship between prognosis (mRankinS) and stroke risk factors and TOAST. RESULTS: Evaluating 86 patients aged 60.5 (±10.1) years (40 men), we identified that small vessel occlusion had a better prognosis (p: 0.031) and cardioembolism a worse prognosis according to mRankinS (p <0.001). Diabetes mellitus also had a worse prognosis (p: 0.021). CONCLUSION: Patients with secondary ischemic stroke small vessel occlusion have a better prognosis according to mRs. Cardioembolic mechanisms and the presence of DM are associated with a worse neurological prognosis

Conhecimento da população sobre acidente vascular cerebral em Torres RS / Knowledge of stroke in Torres-RS population

INTRODUÇÃO: O Acidente Vascular Cerebral (AVC) é uma das principais causas de morbi-mortalidade na América Latina, poucos estudos avaliam o conhecimento da população brasileira sobre o mesmo. OBJETIVO: Avaliar o conhecimento da população de Torres/RS sobre fatores de risco e sinais/sintomas de AVC. MÉTODO: Foi realizado um estudo do tipo transversal de caráter descritivo e exploratório, com entrevista a 375 habitantes, no qual responderam a dois questionários, um sociodemográfico e outro relativo ao conhecimento dos sinais e sintomas do Acidente vascular cerebral. O teste de Qui-Quadrado (χ2) e teste T-student foram realizados para avaliar a associação existente entre as variáveis qualitativas e para verificar diferenças na frequência absoluta e percentual das variáveis. RESULTADOS: A idade média dos participantes foi de 39,7 (+/- 14,6) anos, sendo 230 mulheres, a média de acertos sobre fatores de risco foi de 3.7/11 (34.4%) e de reconhecimento de sinais/sintomas foi de 3,2/10 (32,5%). Em relação aos fatores de risco, Hipertensão Arterial Sistêmica foi descrita por 229 (17,4%) indivíduos e quanto aos sinais/sintomas, o mais descrito foi a Paralisia Facial Central, relatada por 197 (17,2%). Além disso, foi observado que indivíduos com menor nível de instrução, do sexo masculino e com menos de 39 anos, apresentaram um pior desempenho em relação ao conhecimento sobre AVC. CONCLUSÃO: Dessa forma, sugere-se a necessidade de implementar políticas públicas que levem à população informações sobre a importância do reconhecimento destes sinais e sintomas com a necessidade do socorro rápido a este paciente.

INTRODUCTION: Stroke is a leading cause of mortality and disability in Latin America and few paper evaluate the knowledge of brazilian population about this subject. OBJECTIVE: Evaluate the knowledge of Torres/RS about stroke risk factors and signs/symptoms of stroke. METHODS: It was performed a transversal study with 375 inhabitants of Torres, in which they answered two questionnaires, a sociodemographic and the other related to the knowledge of the signs and symptoms of stroke. The Chi-square test (χ2) and the T-student test were performed to assess the association between qualitative variables and to verify differences in the absolute frequency and percentage of variables. RESULTS: The mean age of the participants was 39.7 (+/-14.6) years, (230 were women). The average of correct answers about risk factors was 3.7/11 (34.4%) and recognition of signs/symptoms was 3.2/10 (32.5%). Systemic Arterial Hypertension was the risk factor most recognized by the population (229 individuals). Facial Paralysis reported by 197 individuals was the signs/symptoms most recognized by the Torres population. In addition, it was observed that individuals with a lower level of education, male and under 39 years old, presented a worse performance in relation to knowledge about stroke. CONCLUSION: The implementation of public policies that provide the population information about the importance of the early recognization of stroke signs and symptoms is fundamental for a better result in the care of this disease.

Posterior reversible encephalopathy syndrome: differences between pregnant and non-pregnant patients.

Posterior reversible encephalopathy syndrome (PRES) is a clinical-radiologic entity not yet understood, that presents with transient neurologic symptoms and particular radiological findings. Few papers show the differences between pregnant and non-pregnant patients. We review the cases of 38 women diagnosed with PRES, in order to find significant differences between pregnant (18) and non-pregnant (20) patients. We found differences among the age of patients (25.83 years old in pregnant and 29.31 years old in non pregnant; P=0.001); in the mean of highest systolic blood pressure, that was higher in non-pregnant group (185:162 mmHg; P=0.121); and in creatinine levels that was higher in non-pregnant group (3.47:1.04 mg/dL; P=0.001). To our knowledge, just a few papers analyzed whether PRES syndrome presented in the same way in pregnant and non-pregnant patients. The differences and the possible pathophisiology of this syndrome still remain enigmatic.

Associação entre saúde bucal e acidente vascular encefálico isquêmico (AVEI) - uma revisão da literatura / Association between oral health and ischemic stroke (IS) - a literature review

A associação entre saúde bucal e desfechos de saúde geral vem sendo estudada de modo crescente nas últimas décadas, com ênfase na relação entre doenças inflamatórias crônicas bucais e doenças cardiovasculares (DCV) de origem aterosclerótica. OBJETIVO: revisar a literatura, atualizando os conhecimentos sobre a associação entre parâmetros de saúde bucal (doença periodontal (DP), periodontite apical (PA) e perda dentária) e a ocorrência de acidente vascular encefálico isquêmico (AVEI). METODOLOGIA: foram pesquisadas as seguintes bases eletrônicas, sem restrições de idiomas ou data: PubMed/ MEDLINE, LILACS, Scielo e ISI Web of Science e Schoolar Google, além de buscas manuais. Estudos realizados em animais ou in vitro, relatos e séries de casos foram excluídos. RESULTADOS: a presente revisão identificou e incluiu 11 estudos clínicos observacionais avaliando a associação entre diferentes indicadores de saúde bucal e AVEI, além de uma meta-analise sobre o assunto. Nenhum estudo de intervenção foi identificado. CONCLUSÃO: a evidência disponível, oriunda de estudos observacionias, sugere que as principais doenças inflamatórias crônicas bucais (DP e PA) estão associadas de modo independente com DCV de origem aterosclerótica. A relação entre DP e AVEI parece consistente, porém há carência de estudos analisando a associação entre AVEI e outros parâmetros de saúde bucal, especialmente cárie e PA. Até o momento, uma relação de causalidade entre DP, PA e AVEI não pode ser confirmada ou rejeitada, em face à ausência de estudos de intervenção. Futuros estudos deverão contribuir para o esclarecimento dos mecanismos biológicos que embasam a associação entre as doenças crônicas bucais e o AVEI.

The association between oral health and general health has been under study for decades, with emphasis on the relationship between chronic oral inflammatory diseases and atherosclerotic cardiovascular diseases (ACVD). OBJECTIVE: to review the literature, updating the knowledge about the association between oral health (periodontal disease (PD), apical periodontitis (AP) and tooth loss) and the occurrence of ischemic stroke (IS). METHODOLOGY: the following electronic databases were searched, without language or date restrictions: PubMed/MEDLINE, LILACS, Scielo, ISI Web of Science and Schoolar Google, as well as manual searches. Studies in animals or in vitro, reports and series of cases were excluded. RESULTS: the present review identified and included 11 clinical observational studies evaluating the association between different indicators of oral health and IS, and one meta-analysis on the field. No interventional studies were identified. CONCLUSION: the available evidence from observational studies suggests that the main chronic oral inflammatory diseases (PD and PA) are independently associated with ACVD. In addition, the relationship between PD and IS seems consistent, but there is a lack of studies analyzing the association between IS and other oral health parameters, such as caries and AP. To now, a causal relationship between DP, PA and IS cannot be confirmed or rejected, considering the lack of interventional studies on the area. Future studies should contribute to the comprehension of the biological mechanisms underlying the association between the main chronic oral diseases and IS.

Transtorno de Déficit de Atenção e Hiperatividade e Transtorno de Conduta em adolescentes concluintes do ensino fundamental de Caxias do Sul / Attention Deficit Hyperactivity Disorder and Behavioral Disorder in adolescents who completed elementary education in Caxias do Sul

O Transtorno de Déficit de Atenção e Hiperatividade (TDAH) é uma das comorbidades neuropsiquiátricas mais comuns entre crianças e adolescentes, e caracteriza-se por sintomas de desatenção, hiperatividade e impulsividade. O presente estudo tem por objetivo determinar a prevalência de TDAH em uma amostra de adolescentes na cidade de Caxias do Sul. Trata-se de um estudo transversal realizado com uma amostra de 272 escolares. Como instrumento para triagem do TDAH foi utilizada a versão brasileira do questionário Child Behavior Check List. A prevalência de TDAH foi de 3,7 %; nessa amostra também foi avaliada a prevalência do Transtorno de Conduta que foi de 6,2 %. O Transtorno de Conduta se mostrou mais prevalente em escolares com TDAH. (p=0,019). O presente estudo evidenciou que o TDAH é uma patologia comum entre os adolescentes, apresentando importante associação com Transtorno de Conduta.(AU)

Attention Deficit Hyperactivity Disorder (ADHD) is considered one of the most common neuropsychiatric disorders among children and adolescents and is characterized by symptoms of inattention, hyperactivity and impulsivity. The present study aims to determine the prevalence of ADHD in a sample of adolescents in Caxias do Sul. A cross-sectional study was conducted in a sample of 272 students. The instrument used for screening ADHD was the Brazilian version of the questionnaire Child Behavior Checklist. The prevalence of ADHD was 3.7%; in this sample we also evaluated the prevalence of Conduct Disorder that was 6.2%. Conduct Disorder was more common in students with ADHD. (p = 0.019). The present study evidenced that ADHD is a common comorbidity in adolescents, presenting an important association with Conduct Disorder.(AU)

Mudanças comportamentais e fisiológicas determinadas pelo ciclo biológico feminino ­ climatério à menopausa / Behavioral and physiological changes determined by the female biological cycle ­ climacteric to menopause

A menopausa, período da falência ovariana, aparece como um marco corporal desencadeando sinais e sintomas que necessitam de controle e avaliação para garantir qualidade de vida no processo do envelhecimento feminino. O objetivo deste trabalho foi investigar as ações do estrogênio no período que caracteriza o climatério/menopausa, a partir de uma revisão integrativa, cujos descritores foram: ações do estrogênio, sinais/sintomas do climatério/menopausa e terapia de reposição hormonal. O estrogênio apresenta receptores em todos os órgãos e, portanto, atua nas características anatômicas, fisiológicas e emocionais; estimula o crescimento da massa óssea e muscular; atua como antioxidante; exerce ação cardioprotetora e neuroprotetora; contribui na vitalidade emocional e sexual. Com isso, percebe-se que no climatério ocorre uma redução drástica nos níveis de estrogênio, que culmina com a ausência estrogênica na menopausa e esse fato acarreta desequilíbrio de diferentes sistemas, até atingir uma nova adaptação.(AU)

Menopause appears as a body landmark in the aging process, where along with ovarian failure, it can trigger signs and symptoms that require control and evaluation to ensure a good quality of life. The objective of this work was to investigate how the estrogen actions in the period that characterize the climacteric / menopause. From an integrative review, the descriptors were: estrogenic effects, signs and symptoms of climacteric and menopause and hormone replacement therapy. Estrogen has receptors in all organs and, therefore, acts on anatomical, physiological and emotional characteristics; in determining bone and muscle mass growth; action as antioxidant; as cardioprotective and neuroprotective; contribution to emotional and sexual vitality. It was verified that in the climacteric occurs a reduction of the hormonal levels that culminates with the menopause and that the estrogen absence causes in disequilibrium of different systems, until reaching a new adaptation.(AU)