L-DOPA-Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug-Delivery Vehicles.

Manganese oxide nanoparticles (MONPs) are capable of time-dependent magnetic resonance imaging contrast switching as well as releasing a surface-bound drug. MONPs give T2/T2* contrast, but dissolve and release T1-active Mn(2+) and L-3,4-dihydroxyphenylalanine. Complementary images are acquired with a single contrast agent, and applications toward Parkinson's disease are suggested.

Characterization of Porous Structures of Cellulose Nanofibrils Loaded with Salicylic Acid.

Bleached and unbleached pulp fibers were treated with 2,2,6,6-tetramethylpyperidine-1-oxyl (TEMPO) mediated oxidation to obtain cellulose nanofibrils (CNFs). The resulting bleached and unbleached CNFs were mixed with salicylic acid (0, 5, 10, 20 wt%) before casting and freeze-drying or 3D-printing. A series of methods were tested and implemented to characterize the CNF materials and the porous structures loaded with salicylic acid. The CNFs were characterized with atomic force microscopy and laser profilometry, and release of salicylic acid was quantified with UV-visible absorbance spectroscopy, conductivity measurements, and inductive coupled plasma mass spectrometry (ICP-MS). Fourier-transform infrared spectroscopy (FTIR) complemented the analyses. Herein, we show that aerogels of bleached CNFs yield a greater release of salicylic acid, compared to CNF obtained from unbleached pulp. The results suggest that biodegradable constructs of CNFs can be loaded with a plant hormone that is released slowly over time, which may find uses in small scale agricultural applications and for the private home market.

Synthesis of gadolinium oxide nanodisks and gadolinium doped iron oxide nanoparticles for MR contrast agents.

Herein, we report the synthesis of differently sized gadolinium oxide nanodisks and gadolinium doped iron oxide spherical and cubic nanoparticles through the thermal decomposition of an oleate precursor. We also demonstrate that these nanoparticles are promising candidates for MR contrast agents.