1.
Bioorg Med Chem Lett
; 13(2): 301-4, 2003 Jan 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12482445
RESUMO
Several phosphoramidate analogues of CMP-N-acetylneuraminic acid were prepared for evaluation as inhibitors of alpha-2,3- and alpha-2,6-sialyltransferase. Central to the synthesis was the oxidative coupling of an amino acid ester with an H-phosphonate to construct the phosphoramidate linkage. All compounds synthesized were weak inhibitors of both of the sialyltransferases as determined by an HPLC-based inhibition assay.