Detalhe da pesquisa
1.
Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1.
J Biol Chem
; 298(6): 101974, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35469921
2.
Differences in Metformin and Thiamine Uptake between Human and Mouse Organic Cation Transporter 1: Structural Determinants and Potential Consequences for Intrahepatic Concentrations.
Drug Metab Dispos
; 48(12): 1380-1392, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33037045
3.
Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-Facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake.
Mol Pharmacol
; 93(4): 402-415, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29339398
4.
Isobutyrylcarnitine as a Biomarker of OCT1 Activity and Interspecies Differences in its Membrane Transport.
Front Pharmacol
; 12: 674559, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34040533
5.
Effects of a Common Eight Base Pairs Duplication at the Exon 7-Intron 7 Junction on Splicing, Expression, and Function of OCT1.
Front Pharmacol
; 12: 661480, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34025422
6.
Pharmacokinetic Drug-Drug Interactions Between Trospium Chloride and Ranitidine Substrates of Organic Cation Transporters in Healthy Human Subjects.
J Clin Pharmacol
; 60(3): 312-323, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31542894
7.
Opioids as Substrates and Inhibitors of the Genetically Highly Variable Organic Cation Transporter OCT1.
J Med Chem
; 62(21): 9890-9905, 2019 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31597043
8.
OCT1 Polyspecificity-Friend or Foe?
Front Pharmacol
; 12: 698153, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34149437