Systemic Inflammatory Biomarkers Predict Survival of Patients Treated With Tyrosine Kinase Inhibitors for Metastatic Renal Cell Carcinoma.

OBJECTIVE: We aimed to retrospectively investigate whether the neutrophil to lymphocyte ratio (NLR) and the monocyte to lymphocyte ratio (MLR) can predict the prognosis of patients with metastatic renal cell carcinoma (mRCC) treated with sunitinib or sorafenib. METHODS: We retrospectively identified 210 patients with mRCC treated with sunitinib or sorafenib from 2007 to 2017 at Fudan University- and Hexi University-affiliated hospitals. Overall survival (OS) and progression-free survival (PFS) were evaluated using the Kaplan-Meier method. Multivariate regression analysis was used to evaluate predictors of PFS and OS. RESULTS: Low NLR (<2.85) and MLR (<.30) were strongly associated with increased PFS and OS. Multivariable analyses verified that the NLR and MLR were both independent prognostic factors. Additionally, the NLR was negatively correlated with CD8+ and CD4+ T-cell infiltration in tumors. CONCLUSION: In patients with mRCC treated with sunitinib and sorafenib, an NLR <2.85 and MLR <.30 was associated with superior PFS and OS, which may be related to the reduced lymphocytic infiltration of tumors.

Identification of Zr(iv)-based architectures generated from ligands incorporating the 2,2'-biphenolato unit.

The structural identification in solution of the Zr(iv) complexes involving two 2,2-biphenol-based proligands is reported. The proligand L(1)H2 contains one 2,2-biphenol unit whereas L(2)H4 incorporates two 2,2-biphenol units linked by a para-phenylene bridge. Diffusion Ordered Spectroscopy (DOSY) combined with electrospray mass spectrometry analysis and density functional theory (DFT) allowed for determining the molecular structures of such Zr(iv)-based architectures. It is proposed that [Zr(OPr(i))4(HOPr(i))] in the presence of L(1)H2 generates an octahedral complex formulated as [ZrL(1)3H2]. Concerning the self-assembled architecture incorporating the L(2) ligand, the analytical data highlight the formation of an unprecedented neutral Zr(iv) triple-stranded helicate ([Zr2L(2)3H4]). Insight into the geometry of these complexes is obtained via DFT calculations. Remarkably, the helicate structure characterized in solution strongly contrasts with the triple-stranded structure of the complex that crystallizes.