Detalhe da pesquisa
1.
IW-3718 Reduces Heartburn Severity in Patients With Refractory Gastroesophageal Reflux Disease in a Randomized Trial.
Gastroenterology
; 158(8): 2093-2103, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32092310
2.
Rationale and design for a multicenter, randomized, double-blind, placebo-controlled, phase 2 study evaluating the safety and efficacy of the soluble guanylate cyclase stimulator praliciguat over 12 weeks in patients with heart failure with preserved ejection fraction (CAPACITY HFpEF).
Am Heart J
; 222: 183-190, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32105984
3.
Effect of Praliciguat on Peak Rate of Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction: The CAPACITY HFpEF Randomized Clinical Trial.
JAMA
; 324(15): 1522-1531, 2020 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33079154
4.
No effect on QT intervals of mipomersen, a 2'-O-methoxyethyl modified antisense oligonucleotide targeting ApoB-100 mRNA, in a phase I dose escalation placebo-controlled study, and confirmed by a thorough QT (tQT) study, in healthy subjects.
Eur J Clin Pharmacol
; 72(3): 267-75, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26645588
5.
Long-term efficacy and safety of mipomersen in patients with familial hypercholesterolaemia: 2-year interim results of an open-label extension.
Eur Heart J
; 36(9): 566-75, 2015 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24366918
6.
Interview-Based Patient- and Caregiver-Reported Experiences of Hunger and Improved Quality of Life with Setmelanotide Treatment in Bardet-Biedl Syndrome.
Adv Ther
; 40(5): 2394-2411, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36961653
7.
Efficacy and safety of setmelanotide, a melanocortin-4 receptor agonist, in patients with Bardet-Biedl syndrome and Alström syndrome: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial with an open-label period.
Lancet Diabetes Endocrinol
; 10(12): 859-868, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36356613
8.
Complex effects of inhibiting hepatic apolipoprotein B100 synthesis in humans.
Sci Transl Med
; 8(323): 323ra12, 2016 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26819195