Detalhe da pesquisa
1.
Impact of guanidine-containing backbone linkages on stereopure antisense oligonucleotides in the CNS.
Nucleic Acids Res
; 50(10): 5401-5423, 2022 06 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35106589
2.
Development of a sensitive trial-ready poly(GP) CSF biomarker assay for C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis.
J Neurol Neurosurg Psychiatry
; 93(7): 761-771, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35379698
3.
Novel genomic island modifies DNA with 7-deazaguanine derivatives.
Proc Natl Acad Sci U S A
; 113(11): E1452-9, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26929322
4.
Tracking the processing of damaged DNA double-strand break ends by ligation-mediated PCR: increased persistence of 3'-phosphoglycolate termini in SCAN1 cells.
Nucleic Acids Res
; 42(5): 3125-37, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24371269
5.
Restoration of G1 chemo/radioresistance and double-strand-break repair proficiency by wild-type but not endonuclease-deficient Artemis.
Nucleic Acids Res
; 39(15): 6500-10, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21531702
6.
2022 White Paper on Recent Issues in Bioanalysis: FDA Draft Guidance on Immunogenicity Information in Prescription Drug Labeling, LNP & Viral Vectors Therapeutics/Vaccines Immunogenicity, Prolongation Effect, ADA Affinity, Risk-based Approaches, NGS, qPCR, ddPCR Assays (Part 3 - Recommendations on Gene Therapy, Cell Therapy, Vaccines Immunogenicity & Technologies; Immunogenicity & Risk Assessment of Biotherapeutics and Novel Modalities; NAb Assays Integrated Approach).
Bioanalysis
; 15(14): 773-814, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37526071
7.
Preclinical evaluation of WVE-004, aninvestigational stereopure oligonucleotide forthe treatment of C9orf72-associated ALS or FTD.
Mol Ther Nucleic Acids
; 28: 558-570, 2022 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35592494
8.
Requirement for XLF/Cernunnos in alignment-based gap filling by DNA polymerases lambda and mu for nonhomologous end joining in human whole-cell extracts.
Nucleic Acids Res
; 37(12): 4055-62, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19420065
9.
Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides.
Nat Biotechnol
; 35(9): 845-851, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28829437
10.
Trimming of damaged 3' overhangs of DNA double-strand breaks by the Metnase and Artemis endonucleases.
DNA Repair (Amst)
; 12(6): 422-32, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23602515
11.
Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.
DNA Repair (Amst)
; 8(8): 901-11, 2009 Aug 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-19505854