Detalhe da pesquisa
1.
Inhibition mechanisms of AcrF9, AcrF8, and AcrF6 against type I-F CRISPR-Cas complex revealed by cryo-EM.
Proc Natl Acad Sci U S A
; 117(13): 7176-7182, 2020 03 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32170016
2.
Cryo-EM structures of Helicobacter pylori vacuolating cytotoxin A oligomeric assemblies at near-atomic resolution.
Proc Natl Acad Sci U S A
; 116(14): 6800-6805, 2019 04 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30894496
3.
Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.
Proc Natl Acad Sci U S A
; 114(33): E6942-E6951, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28760974
4.
Effect of a K72A Mutation on the Structure, Stability, Dynamics, and Peroxidase Activity of Human Cytochrome c.
Biochemistry
; 56(26): 3358-3368, 2017 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28598148
5.
Structure of a mitochondrial cytochrome c conformer competent for peroxidase activity.
Proc Natl Acad Sci U S A
; 111(18): 6648-53, 2014 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24760830
6.
Cytochrome c Can Form a Well-Defined Binding Pocket for Hydrocarbons.
J Am Chem Soc
; 138(51): 16770-16778, 2016 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27990813
7.
A next-generation BRAF inhibitor overcomes resistance to BRAF inhibition in patients with BRAF-mutant cancers using pharmacokinetics-informed dose escalation.
Cancer Discov
; 2024 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38691346
8.
Application of sulfur SAD to small crystals with a large asymmetric unit and anomalous substructure.
Acta Crystallogr D Struct Biol
; 78(Pt 8): 1021-1031, 2022 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35916226
9.
Structural basis for the high-affinity inhibition of mammalian membranous adenylyl cyclase by 2',3'-o-(N-methylanthraniloyl)-inosine 5'-triphosphate.
Mol Pharmacol
; 80(1): 87-96, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21498658
10.
The structure of the cysteine-rich region from human histone-lysine N-methyltransferase EHMT2 (G9a).
J Struct Biol X
; 5: 100050, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34278292
11.
Stereoselective synthesis of novel 2'-(S)-CCG-IV analogues as potent NMDA receptor agonists.
Eur J Med Chem
; 212: 113099, 2021 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33383257
12.
Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1.
Nat Commun
; 11(1): 1077, 2020 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32103024
13.
Structural basis for inhibition of mammalian adenylyl cyclase by calcium.
Biochemistry
; 48(15): 3387-97, 2009 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-19243146
14.
Differential inhibition of various adenylyl cyclase isoforms and soluble guanylyl cyclase by 2',3'-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5'-triphosphates.
J Pharmacol Exp Ther
; 330(3): 687-95, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19494187
15.
Cryo-EM structure of a 40 kDa SAM-IV riboswitch RNA at 3.7 Å resolution.
Nat Commun
; 10(1): 5511, 2019 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31796736
16.
Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A.
Structure
; 27(7): 1137-1147.e5, 2019 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31155309
17.
Activation and inhibition of adenylyl cyclase isoforms by forskolin analogs.
J Pharmacol Exp Ther
; 325(1): 27-36, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18184830
18.
Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene.
PLoS One
; 13(10): e0205584, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30312328
19.
The high binding affinity of phosphorothioate-modified oligomers for Ff gene 5 protein is moderated by the addition of C-5 propyne or 2'-O-methyl modifications.
Nucleic Acids Res
; 30(3): 749-58, 2002 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-11809888
20.
2'-O-methyl-modified phosphorothioate antisense oligonucleotides have reduced non-specific effects in vitro.
Nucleic Acids Res
; 32(6): 2008-16, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15064360