Detalhe da pesquisa
1.
Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription.
Mol Cell
; 77(6): 1322-1339.e11, 2020 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32006464
2.
Mono- and multimeric PSMA-targeting small molecule-thorium-227 conjugates for optimized efficacy and biodistribution in preclinical models.
Eur J Nucl Med Mol Imaging
; 51(3): 669-680, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37882848
3.
Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription.
Mol Cell
; 81(11): 2495, 2021 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34087181
4.
Enhanced Antitumor Efficacy of Radium-223 and Enzalutamide in the Intratibial LNCaP Prostate Cancer Model.
Int J Mol Sci
; 24(3)2023 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36768509
5.
A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy.
Bioconjug Chem
; 33(6): 1210-1221, 2022 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35658441
6.
Additive Benefits of Radium-223 Dichloride and Bortezomib Combination in a Systemic Multiple Myeloma Mouse Model.
Int J Mol Sci
; 22(11)2021 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34070363
7.
Darolutamide is a potent androgen receptor antagonist with strong efficacy in prostate cancer models.
Int J Cancer
; 145(5): 1382-1394, 2019 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30828788
8.
Rogaratinib: A potent and selective pan-FGFR inhibitor with broad antitumor activity in FGFR-overexpressing preclinical cancer models.
Int J Cancer
; 145(5): 1346-1357, 2019 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30807645
9.
Functional and Structural Characterization of Bub3·BubR1 Interactions Required for Spindle Assembly Checkpoint Signaling in Human Cells.
J Biol Chem
; 291(21): 11252-67, 2016 05 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27030009
10.
BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models.
Int J Cancer
; 140(2): 449-459, 2017 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27699769
11.
Dual targeting of the androgen receptor and PI3K/AKT/mTOR pathways in prostate cancer models improves antitumor efficacy and promotes cell apoptosis.
Mol Oncol
; 18(3): 726-742, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38225213
12.
Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling.
Cell Chem Biol
; 2024 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38537632
13.
Zoledronic Acid Prevents Bone Resorption Caused by the Combination of Radium-223, Abiraterone Acetate, and Prednisone in an Intratibial Prostate Cancer Mouse Model.
Cancers (Basel)
; 15(16)2023 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37627143
14.
A Targeted Thorium-227 Conjugate Demonstrates Efficacy in Preclinical Models of Acquired Drug Resistance and Combination Potential with Chemotherapeutics and Antiangiogenic Therapies.
Mol Cancer Ther
; 22(9): 1073-1086, 2023 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37365121
15.
Comparative Proteomic and Transcriptomic Analysis of the Impact of Androgen Stimulation and Darolutamide Inhibition.
Cancers (Basel)
; 15(1)2022 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36611998
16.
Antibody-drug conjugates harboring a kinesin spindle protein inhibitor with immunostimulatory properties.
Oncoimmunology
; 11(1): 2037216, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35154909
17.
Identification of a neural development gene expression signature in colon cancer stem cells reveals a role for EGR2 in tumorigenesis.
iScience
; 25(7): 104498, 2022 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35720265
18.
DNA repair inhibitors sensitize cells differently to high and low LET radiation.
Sci Rep
; 11(1): 23257, 2021 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34853427
19.
RNA sequencing of long-term label-retaining colon cancer stem cells identifies novel regulators of quiescence.
iScience
; 24(6): 102618, 2021 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34142064
20.
Darolutamide Potentiates the Antitumor Efficacy of a PSMA-targeted Thorium-227 Conjugate by a Dual Mode of Action in Prostate Cancer Models.
Clin Cancer Res
; 27(15): 4367-4378, 2021 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34035067