Detalhe da pesquisa
1.
Identification and functional evaluation of GRIA1 missense and truncation variants in individuals with ID: An emerging neurodevelopmental syndrome.
Am J Hum Genet
; 109(7): 1217-1241, 2022 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35675825
2.
A single historical substitution drives an increase in acetylcholine receptor complexity.
Proc Natl Acad Sci U S A
; 118(7)2021 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33579823
3.
Coupling structure with function in acid-sensing ion channels: challenges in pursuit of proton sensors.
J Physiol
; 599(2): 417-430, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32306405
4.
The V2475F CPVT1 mutation yields distinct RyR2 channel populations that differ in their responses to cytosolic Ca2+ and Mg2.
J Physiol
; 599(23): 5179-5201, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34676560
5.
Identification of compounds that bind the centriolar protein SAS-6 and inhibit its oligomerization.
J Biol Chem
; 295(52): 17922-17934, 2020 12 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32873708
6.
Mutational Analysis and Modeling of Negative Allosteric Modulator Binding Sites in AMPA Receptors.
Mol Pharmacol
; 96(6): 835-850, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31582576
7.
Role of the Cys Loop and Transmembrane Domain in the Allosteric Modulation of α4ß2 Nicotinic Acetylcholine Receptors.
J Biol Chem
; 292(2): 551-562, 2017 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27864368
8.
Functional Validation of Heteromeric Kainate Receptor Models.
Biophys J
; 113(10): 2173-2177, 2017 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28935133
9.
Kainate receptor pore-forming and auxiliary subunits regulate channel block by a novel mechanism.
J Physiol
; 594(7): 1821-40, 2016 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26682513
10.
Steered Molecular Dynamics Simulations Predict Conformational Stability of Glutamate Receptors.
J Chem Inf Model
; 56(9): 1787-97, 2016 09 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27482759
11.
Ion pathways in the sarcoplasmic reticulum Ca2+-ATPase.
J Biol Chem
; 288(15): 10759-65, 2013 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23400778
12.
Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure.
FEBS J
; 291(7): 1506-1529, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38145505
13.
Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains.
J Gen Physiol
; 155(3)2023 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36625864
14.
Tracing cytoplasmic Ca(2+) ion and water access points in the Ca(2+)-ATPase.
Biophys J
; 102(2): 268-77, 2012 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22339863
15.
Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG-CoA reductase inhibition.
Br J Pharmacol
; 179(21): 4941-4957, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35703154
16.
Protonation states of important acidic residues in the central Ca²âº ion binding sites of the Ca²âº-ATPase: a molecular modeling study.
Biochemistry
; 50(51): 11109-20, 2011 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22082179
17.
Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter.
J Biol Chem
; 285(11): 8363-74, 2010 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19948720
18.
Molecular Investigation of Chicken Acid-Sensing Ion Channel 1 ß11-12 Linker Isomerization and Channel Kinetics.
Front Cell Neurosci
; 15: 761813, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34924957
19.
Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1.
J Gen Physiol
; 153(8)2021 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34061161
20.
P-type ATPases as drug targets: tools for medicine and science.
Biochim Biophys Acta
; 1787(4): 207-20, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19388138