Detalhe da pesquisa
1.
1,2-Difunctionalized bicyclo[1.1.1]pentanes: Long-sought-after mimetics for ortho/meta-substituted arenes.
Proc Natl Acad Sci U S A
; 118(28)2021 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34244445
2.
Recent progress on third generation covalent EGFR inhibitors.
Bioorg Med Chem Lett
; 26(8): 1861-8, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26968253
3.
Synthesis of Small 3-Fluoro- and 3,3-Difluoropyrrolidines Using Azomethine Ylide Chemistry.
J Org Chem
; 80(14): 7266-74, 2015 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26057617
4.
Construction of Isoquinolone Scaffolds on DNA via Rhodium(III)-Catalyzed C-H Activation.
Org Lett
; 26(16): 3338-3342, 2024 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38608176
5.
N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11ß-hydroxysteroid dehydrogenase type 1: strategies to eliminate reactive metabolites.
Bioorg Med Chem Lett
; 23(8): 2344-8, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23489629
6.
Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.
J Med Chem
; 66(7): 4888-4909, 2023 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36940470
7.
Total synthesis and evaluation of C26-hydroxyepothilone D derivatives for photoaffinity labeling of beta-tubulin.
J Org Chem
; 75(1): 86-94, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19954175
8.
Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility.
Bioorg Med Chem Lett
; 20(10): 3039-42, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20403696
9.
The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors.
Bioorg Med Chem Lett
; 20(9): 2897-902, 2010 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20363126
10.
Multifaceted Substrate-Ligand Interactions Promote the Copper-Catalyzed Hydroboration of Benzylidenecyclobutanes and Related Compounds.
ACS Catal
; 10(21): 13075-13083, 2020 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33791144
11.
Total synthesis and evaluation of 22-(3-azidobenzoyloxy)methyl epothilone C for photoaffinity labeling of beta-tubulin.
Bioorg Med Chem Lett
; 19(12): 3293-6, 2009 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19428248
12.
N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275.
Bioorg Med Chem Lett
; 19(13): 3493-7, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19473839
13.
Total synthesis and evaluation of C25-benzyloxyepothilone C for tubulin assembly and cytotoxicity against MCF-7 breast cancer cells.
Bioorg Med Chem Lett
; 18(17): 4904-6, 2008 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18684624
14.
Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.
J Med Chem
; 60(7): 3002-3019, 2017 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28287730
15.
Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.
J Med Chem
; 59(5): 2005-24, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26756222
16.
Preparation and physicochemical characterization of a novel water-soluble prodrug of carbamazepine.
J Pharm Sci
; 99(4): 1810-25, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19774656
17.
2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases.
Bioorg Med Chem Lett
; 17(12): 3349-53, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17434304
18.
Synthesis of cryptophycins via an N-acyl-beta-lactam macrolactonization.
J Org Chem
; 68(25): 9687-93, 2003 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-14656095