Detalhe da pesquisa
1.
The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity.
Nat Immunol
; 18(5): 519-529, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28346409
2.
Structural basis of GPBAR activation and bile acid recognition.
Nature
; 587(7834): 499-504, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32698187
3.
Discovery of betulinic acid derivatives as gut-restricted TGR5 agonists: Balancing the potency and physicochemical properties.
Bioorg Chem
; 144: 107132, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38241768
4.
GPR84 regulates pulmonary inflammation by modulating neutrophil functions.
Acta Pharmacol Sin
; 44(8): 1665-1675, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37016043
5.
Strigolactone mimic 2-nitrodebranone is highly active in Arabidopsis growth and development.
Plant J
; 107(1): 67-76, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33860570
6.
Epilepsy phenotype and response to KCNQ openers in mice harboring the Kcnq2 R207W voltage-sensor mutation.
Neurobiol Dis
; 174: 105860, 2022 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-36113748
7.
DWARF14 is a non-canonical hormone receptor for strigolactone.
Nature
; 536(7617): 469-73, 2016 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27479325
8.
GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages.
Acta Pharmacol Sin
; 43(8): 2042-2054, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34912006
9.
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma.
Acta Pharmacol Sin
; 43(4): 1091-1099, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-34341512
10.
Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue.
Acta Pharmacol Sin
; 42(6): 964-974, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-32934347
11.
AMPK activator C24 inhibits hepatic lipogenesis and ameliorates dyslipidemia in HFHC diet-induced animal models.
Acta Pharmacol Sin
; 42(4): 585-592, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-32724176
12.
Berberine derivatives with a long alkyl chain branched by hydroxyl group and methoxycarbonyl group at 9-position show improved anti-proliferation activity and membrane permeability in A549 cells.
Acta Pharmacol Sin
; 41(6): 813-824, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-31949294
13.
Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core.
Acta Pharmacol Sin
; 41(3): 293-302, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-31316182
14.
Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux.
Acta Pharmacol Sin
; 40(7): 908-918, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-30560904
15.
Inhibition of KCNQ2/3 channels by HN38 and XE991 depends on the conformation of the outer vestibule.
Mol Pharmacol
; 2018 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-30504241
16.
Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice.
Acta Pharmacol Sin
; 39(10): 1622-1632, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-29795358
17.
Endogenous Bioactive Jasmonate Is Composed of a Set of (+)-7-iso-JA-Amino Acid Conjugates.
Plant Physiol
; 172(4): 2154-2164, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27756820
18.
Discovery of a novel calcium-sensitive fluorescent probe for α-ketoglutarate.
Acta Pharmacol Sin
; 38(12): 1683-1690, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28713156
19.
A negative allosteric modulator modulates GABAB-receptor signalling through GB2 subunits.
Biochem J
; 473(6): 779-87, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26772870
20.
Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2).
Org Biomol Chem
; 14(2): 747-751, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26584338