Detalhe da pesquisa
1.
Small-molecule IKKß activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth.
Proc Natl Acad Sci U S A
; 119(18): e2115071119, 2022 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35476515
2.
The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulates KRAS expression in pancreatic ductal adenocarcinoma cells.
Nucleic Acids Res
; 50(6): 3394-3412, 2022 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35286386
3.
PROTACs in Ovarian Cancer: Current Advancements and Future Perspectives.
Int J Mol Sci
; 25(10)2024 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38791105
4.
Spirocyclic dimer SpiD7 activates the unfolded protein response to selectively inhibit growth and induce apoptosis of cancer cells.
J Biol Chem
; 298(5): 101890, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35378132
5.
Design, synthesis, and evaluation of a mitoxantrone probe (MXP) for biological studies.
Bioorg Med Chem Lett
; 94: 129465, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37669721
6.
Dimers of isatin derived α-methylene-γ-butyrolactone as potent anti-cancer agents.
Bioorg Med Chem Lett
; 65: 128713, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35367592
7.
Aminopyrazole based CDK9 PROTAC sensitizes pancreatic cancer cells to venetoclax.
Bioorg Med Chem Lett
; 43: 128061, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33895280
8.
CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax.
Mol Pharmacol
; 96(4): 419-429, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31467029
9.
A simple fluorescent assay for the discovery of protein-protein interaction inhibitors.
Anal Biochem
; 569: 46-52, 2019 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30707898
10.
Selective degradation of CDK6 by a palbociclib based PROTAC.
Bioorg Med Chem Lett
; 29(11): 1375-1379, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30935795
11.
Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy.
Bioorg Med Chem Lett
; 28(23-24): 3736-3740, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30343954
12.
Characterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor Design.
PLoS Comput Biol
; 12(8): e1005057, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27560145
13.
A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells.
J Biol Chem
; 289(44): 30443-30458, 2014 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-25225290
14.
Irreversible binding of an anticancer compound (BI-94) to plasma proteins.
Xenobiotica
; 45(10): 858-73, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25869245
15.
Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases.
Biochim Biophys Acta
; 1833(1): 122-39, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23085373
16.
Protein Structure Inspired Drug Discovery.
bioRxiv
; 2024 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38826221
17.
DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation.
bioRxiv
; 2024 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37066260
18.
Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects.
Cancer Res Commun
; 4(5): 1328-1343, 2024 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38687198
19.
Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis.
Nat Cell Biol
; 26(4): 613-627, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38429478
20.
Pulse design for broadband correlation NMR spectroscopy by multi-rotating frames.
J Biomol NMR
; 55(3): 291-302, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23420125