Detalhe da pesquisa
1.
Molecular Basis of the Functional Differences between Soluble Human Versus Murine MD-2: Role of Val135 in Transfer of Lipopolysaccharide from CD14 to MD-2.
J Immunol
; 196(5): 2309-18, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26826249
2.
Activation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate of Burkholderia cenocepacia.
J Biol Chem
; 290(35): 21305-19, 2015 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26160169
3.
Tetraacylated lipid A and paclitaxel-selective activation of TLR4/MD-2 conferred through hydrophobic interactions.
J Immunol
; 192(4): 1887-95, 2014 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24420921
4.
Novel roles of lysines 122, 125, and 58 in functional differences between human and murine MD-2.
J Immunol
; 183(8): 5138-45, 2009 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19783674
5.
Toll-like receptor 4 activation in cancer progression and therapy.
Clin Dev Immunol
; 2011: 609579, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-22110526
6.
Glycolipid-based TLR4 Modulators and Fluorescent Probes: Rational Design, Synthesis, and Biological Properties.
Chem Biol Drug Des
; 88(2): 217-29, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26896420
7.
The molecular mechanism of species-specific recognition of lipopolysaccharides by the MD-2/TLR4 receptor complex.
Mol Immunol
; 63(2): 134-42, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25037631
8.
MD-2 determinants of nickel and cobalt-mediated activation of human TLR4.
PLoS One
; 10(3): e0120583, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25803856
9.
Species-specific activation of TLR4 by hypoacylated endotoxins governed by residues 82 and 122 of MD-2.
PLoS One
; 9(9): e107520, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25203747
10.
Development of αGlcN(1â1)αMan-based lipid A mimetics as a novel class of potent Toll-like receptor 4 agonists.
J Med Chem
; 57(19): 8056-71, 2014 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25252784
11.
A bistable genetic switch based on designable DNA-binding domains.
Nat Commun
; 5: 5007, 2014 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-25264186
12.
Trehalose- and glucose-derived glycoamphiphiles: small-molecule and nanoparticle Toll-like receptor 4 (TLR4) modulators.
J Med Chem
; 57(21): 9105-23, 2014 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25268544
13.
Delivery system for the enhanced efficiency of immunostimulatory nucleic acids.
Innate Immun
; 19(1): 53-65, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22732733
14.
Conformationally constrained lipid A mimetics for exploration of structural basis of TLR4/MD-2 activation by lipopolysaccharide.
ACS Chem Biol
; 8(11): 2423-32, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23952219
15.
Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin.
J Biol Chem
; 284(22): 15052-60, 2009 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-19321453