Pesquisa | Portal de Pesquisa da BVS

1.

Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages.

Obradovic, Aleksandar; Chowdhury, Nivedita; Haake, Scott M; Ager, Casey; Wang, Vinson; Vlahos, Lukas; Guo, Xinzheng V; Aggen, David H; Rathmell, W Kimryn; Jonasch, Eric; Johnson, Joyce E; Roth, Marc; Beckermann, Kathryn E; Rini, Brian I; McKiernan, James; Califano, Andrea; Drake, Charles G.

Cell ; 184(11): 2988-3005.e16, 2021 05 27.

Artigo em Inglês | MEDLINE | ID: mdl-34019793

2.

BCG invokes superior STING-mediated innate immune response over radiotherapy in a carcinogen murine model of urothelial cancer.

Lombardo, Kara A; Obradovic, Aleksandar; Singh, Alok Kumar; Liu, James L; Joice, Gregory; Kates, Max; Bishai, William; McConkey, David; Chaux, Alcides; Eich, Marie-Lisa; Rezaei, M Katayoon; Netto, George J; Drake, Charles G; Tran, Phuoc; Matoso, Andres; Bivalacqua, Trinity J.

J Pathol ; 256(2): 223-234, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-34731491

3.

T cell repertoire analysis suggests a prominent bystander response in human cardiac allograft vasculopathy.

Habal, Marlena V; Miller, April M I; Rao, Samhita; Lin, Sijie; Obradovic, Aleksandar; Khosravi-Maharlooei, Mohsen; See, Sarah B; Roy, Poulomi; Shihab, Ronzon; Ho, Siu-Hong; Marboe, Charles C; Naka, Yoshifumi; Takeda, Koji; Restaino, Susan; Han, Arnold; Mancini, Donna; Givertz, Michael; Madsen, Joren C; Sykes, Megan; Addonizio, Linda J; Farr, Maryjane A; Zorn, Emmanuel.

Am J Transplant ; 21(4): 1465-1476, 2021 04.

Artigo em Inglês | MEDLINE | ID: mdl-33021057

4.

Role of the thymus in spontaneous development of a multi-organ autoimmune disease in human immune system mice.

Khosravi-Maharlooei, Mohsen; Li, HaoWei; Hoelzl, Markus; Zhao, Guiling; Ruiz, Amanda; Misra, Aditya; Li, Yang; Teteloshvili, Nato; Nauman, Grace; Danzl, Nichole; Ding, Xiaolan; Pinker, Elisha Y; Obradovic, Aleksandar; Yang, Yong-Guang; Iuga, Alina; Creusot, Remi J; Winchester, Robert; Sykes, Megan.

J Autoimmun ; 119: 102612, 2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-33611150

5.

Deletion of donor-reactive T cell clones after human liver transplant.

Savage, Thomas M; Shonts, Brittany A; Lau, Saiping; Obradovic, Aleksandar; Robins, Harlan; Shaked, Abraham; Shen, Yufeng; Sykes, Megan.

Am J Transplant ; 20(2): 538-545, 2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-31509321

6.

Siplizumab selectively depletes effector memory T cells and promotes a relative expansion of alloreactive regulatory T cells in vitro.

Podestà, Manuel A; Binder, Christian; Sellberg, Felix; DeWolf, Susan; Shonts, Brittany; Ho, Siu-Hong; Obradovic, Aleksandar; Waffarn, Elizabeth; Danzl, Nichole; Berglund, David; Sykes, Megan.

Am J Transplant ; 20(1): 88-100, 2020 01.

Artigo em Inglês | MEDLINE | ID: mdl-31319439

7.

Celebrating the third World Field Epidemiology Day: a focus on MediPIET the field epidemiology training programme in Mediterranean and Black Sea countries.

Obradovic, Aleksandar.

Euro Surveill ; 28(36)2023 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-37676149

8.

Silencing the α2 subunit of Î³-aminobutyric acid type A receptors in rat dorsal root ganglia reveals its major role in antinociception posttraumatic nerve injury.

Obradovic, Aleksandar L; Scarpa, Joseph; Osuru, Hari P; Weaver, Janelle L; Park, Ji-Yong; Pathirathna, Sriyani; Peterkin, Alexander; Lim, Yunhee; Jagodic, Miljenko M; Todorovic, Slobodan M; Jevtovic-Todorovic, Vesna.

Anesthesiology ; 123(3): 654-67, 2015 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-26164299

9.

Dynamic establishment of recipient resident memory T cell repertoire after human intestinal transplantation.

Jiao, Wenyu; Martinez, Mercedes; Muntnich, Constanza Bay; Zuber, Julien; Parks, Christopher; Obradovic, Aleksandar; Tian, Guangyao; Wang, Zicheng; Long, Katherine D; Waffarn, Elizabeth; Frangaj, Kristjana; Jones, Rebecca; Gorur, Alaka; Shonts, Brittany; Rogers, Kortney; Lv, Guoyue; Velasco, Monica; Ravella, Shilpa; Weiner, Joshua; Kato, Tomoaki; Shen, Yufeng; Fu, Jianing; Sykes, Megan.

EBioMedicine ; 101: 105028, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38422982

10.

Elucidation and Pharmacologic Targeting of Master Regulator Dependencies in Coexisting Diffuse Midline Glioma Subpopulations.

Fernández, Ester Calvo; Tomassoni, Lorenzo; Zhang, Xu; Wang, Junqiang; Obradovic, Aleksandar; Laise, Pasquale; Griffin, Aaron T; Vlahos, Lukas; Minns, Hanna E; Morales, Diana V; Simmons, Christian; Gallitto, Matthew; Wei, Hong-Jian; Martins, Timothy J; Becker, Pamela S; Crawford, John R; Tzaridis, Theophilos; Wechsler-Reya, Robert J; Garvin, James; Gartrell, Robyn D; Szalontay, Luca; Zacharoulis, Stergios; Wu, Cheng-Chia; Zhang, Zhiguo; Califano, Andrea; Pavisic, Jovana.

bioRxiv ; 2024 Mar 17.

Artigo em Inglês | MEDLINE | ID: mdl-38559080

11.

Immunomodulatory response to neoadjuvant nivolumab in non-metastatic clear cell renal cell carcinoma.

Singla, Nirmish; Nirschl, Thomas R; Obradovic, Aleksandar Z; Shenderov, Eugene; Lombardo, Kara; Liu, Xiaopu; Pons, Alice; Zarif, Jelani C; Rowe, Steven P; Trock, Bruce J; Hammers, Hans J; Bivalacqua, Trinity J; Pierorazio, Phillip M; Deutsch, Julie S; Lotan, Tamara L; Taube, Janis M; Ged, Yasser M A; Gorin, Michael A; Allaf, Mohamad E; Drake, Charles G.

Sci Rep ; 14(1): 1458, 2024 01 17.

Artigo em Inglês | MEDLINE | ID: mdl-38228729

12.

Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes.

Fu, Jianing; Wang, Zicheng; Martinez, Mercedes; Obradovic, Aleksandar; Jiao, Wenyu; Frangaj, Kristjana; Jones, Rebecca; Guo, Xinzheng V; Zhang, Ya; Kuo, Wan-I; Ko, Huaibin M; Iuga, Alina; Bay Muntnich, Constanza; Prada Rey, Adriana; Rogers, Kortney; Zuber, Julien; Ma, Wenji; Miron, Michelle; Farber, Donna L; Weiner, Joshua; Kato, Tomoaki; Shen, Yufeng; Sykes, Megan.

J Exp Med ; 221(1)2024 Jan 01.

Artigo em Inglês | MEDLINE | ID: mdl-38091025

13.

Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies.

Zaidi, Samir; Park, Jooyoung; Chan, Joseph M; Roudier, Martine P; Zhao, Jimmy L; Gopalan, Anuradha; Wadosky, Kristine M; Patel, Radhika A; Sayar, Erolcan; Karthaus, Wouter R; Henry Kates, D; Chaudhary, Ojasvi; Xu, Tianhao; Masilionis, Ignas; Mazutis, Linas; Chaligné, Ronan; Obradovic, Aleksandar; Linkov, Irina; Barlas, Afsar; Jungbluth, Achim; Rekhtman, Natasha; Silber, Joachim; Manova-Todorova, Katia; Watson, Philip A; True, Lawrence D; Morrissey, Colm M; Scher, Howard I; Rathkopf, Dana; Morris, Michael J; Goodrich, David W; Choi, Jungmin; Nelson, Peter S; Haffner, Michael C; Sawyers, Charles L.

bioRxiv ; 2024 Apr 12.

Artigo em Inglês | MEDLINE | ID: mdl-38645034

14.

Precision immunotherapy.

Obradovic, Aleksandar.

Science ; 379(6633): 654-655, 2023 02 17.

Artigo em Inglês | MEDLINE | ID: mdl-36795815

15.

Impact of COVID-19 Pandemic on Physician-Scientist Trainees to Faculty One Year into the Pandemic.

Obradovic, Aleksandar; Toubat, Omar; Chen, Nathan W; Siebert, Aisha; Jansen, Carey; Christophers, Briana; Leveille, Etienne; Noch, Evan; Kwan, Jennifer M.

Res Sq ; 2023 Nov 08.

Artigo em Inglês | MEDLINE | ID: mdl-37986886

16.

KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response.

Ager, Casey R; Zhang, Mingxuan; Chaimowitz, Matthew; Bansal, Shruti; Obradovic, Aleksandar; Rogava, Meri; Melms, Johannes C; McCann, Patrick; Spina, Catherine; Drake, Charles G; Dallos, Matthew C; Izar, Benjamin.

bioRxiv ; 2023 Jan 02.

Artigo em Inglês | MEDLINE | ID: mdl-36711647

17.

KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response.

Ager, Casey R; Zhang, Mingxuan; Chaimowitz, Matthew; Bansal, Shruti; Tagore, Somnath; Obradovic, Aleksandar; Jugler, Collin; Rogava, Meri; Melms, Johannes C; McCann, Patrick; Spina, Catherine; Drake, Charles G; Dallos, Matthew C; Izar, Benjamin.

J Immunother Cancer ; 11(9)2023 09.

Artigo em Inglês | MEDLINE | ID: mdl-37657842

18.

Li-Fraumeni Syndrome-Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death.

Choe, Joshua H; Kawase, Tatsuya; Xu, An; Guzman, Asja; Obradovic, Aleksandar Z; Low-Calle, Ana Maria; Alaghebandan, Bita; Raghavan, Ananya; Long, Kaitlin; Hwang, Paul M; Schiffman, Joshua D; Zhu, Yan; Zhao, Ruiying; Lee, Dung-Fang; Katz, Chen; Prives, Carol.

Cancer Discov ; 13(5): 1250-1273, 2023 05 04.

Artigo em Inglês | MEDLINE | ID: mdl-37067901

19.

Systematic elucidation and pharmacological targeting of tumor-infiltrating regulatory T cell master regulators.

Obradovic, Aleksandar; Ager, Casey; Turunen, Mikko; Nirschl, Thomas; Khosravi-Maharlooei, Mohsen; Iuga, Alina; Jackson, Christopher M; Yegnasubramanian, Srinivasan; Tomassoni, Lorenzo; Fernandez, Ester Calvo; McCann, Patrick; Rogava, Meri; DeMarzo, Angelo M; Kochel, Christina M; Allaf, Mohamad; Bivalacqua, Trinity; Lim, Michael; Realubit, Ronald; Karan, Charles; Drake, Charles G; Califano, Andrea.

Cancer Cell ; 41(5): 933-949.e11, 2023 05 08.

Artigo em Inglês | MEDLINE | ID: mdl-37116491

20.

Anti-PD-1 immunotherapy with androgen deprivation therapy induces robust immune infiltration in metastatic castration-sensitive prostate cancer.

Hawley, Jessica E; Obradovic, Aleksandar Z; Dallos, Matthew C; Lim, Emerson A; Runcie, Karie; Ager, Casey R; McKiernan, James; Anderson, Christopher B; Decastro, Guarionex J; Weintraub, Joshua; Virk, Renu; Lowy, Israel; Hu, Jianhua; Chaimowitz, Matthew G; Guo, Xinzheng V; Zhang, Ya; Haffner, Michael C; Worley, Jeremy; Stein, Mark N; Califano, Andrea; Drake, Charles G.

Cancer Cell ; 41(11): 1972-1988.e5, 2023 11 13.

Artigo em Inglês | MEDLINE | ID: mdl-37922910

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Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages.

BCG invokes superior STING-mediated innate immune response over radiotherapy in a carcinogen murine model of urothelial cancer.

T cell repertoire analysis suggests a prominent bystander response in human cardiac allograft vasculopathy.

Role of the thymus in spontaneous development of a multi-organ autoimmune disease in human immune system mice.

Deletion of donor-reactive T cell clones after human liver transplant.

Siplizumab selectively depletes effector memory T cells and promotes a relative expansion of alloreactive regulatory T cells in vitro.

Celebrating the third World Field Epidemiology Day: a focus on MediPIET the field epidemiology training programme in Mediterranean and Black Sea countries.

Silencing the α2 subunit of Î³-aminobutyric acid type A receptors in rat dorsal root ganglia reveals its major role in antinociception posttraumatic nerve injury.

Dynamic establishment of recipient resident memory T cell repertoire after human intestinal transplantation.

Elucidation and Pharmacologic Targeting of Master Regulator Dependencies in Coexisting Diffuse Midline Glioma Subpopulations.

Immunomodulatory response to neoadjuvant nivolumab in non-metastatic clear cell renal cell carcinoma.

Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes.

Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies.

Precision immunotherapy.

Impact of COVID-19 Pandemic on Physician-Scientist Trainees to Faculty One Year into the Pandemic.

KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response.

KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response.

Li-Fraumeni Syndrome-Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death.

Systematic elucidation and pharmacological targeting of tumor-infiltrating regulatory T cell master regulators.

Anti-PD-1 immunotherapy with androgen deprivation therapy induces robust immune infiltration in metastatic castration-sensitive prostate cancer.