Detalhe da pesquisa
1.
Modeling mammalian spermatogonial differentiation and meiotic initiation in vitro.
Development
; 149(22)2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36250451
2.
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis.
Med Res Rev
; 43(6): 2260-2302, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37243319
3.
Importance of lipids for upper motor neuron health and disease.
Semin Cell Dev Biol
; 112: 92-104, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33323321
4.
SBT-272 improves TDP-43 pathology in ALS upper motor neurons by modulating mitochondrial integrity, motility, and function.
Neurobiol Dis
; 178: 106022, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36716828
5.
Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease.
Hum Mol Genet
; 26(4): 686-701, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28040732
6.
MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology.
J Neuroinflammation
; 16(1): 196, 2019 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31666087
7.
Complexity of Generating Mouse Models to Study the Upper Motor Neurons: Let Us Shift Focus from Mice to Neurons.
Int J Mol Sci
; 20(16)2019 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31394733
8.
Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms.
Hum Mol Genet
; 25(6): 1074-87, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26755825
9.
A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity.
Hum Mol Genet
; 24(7): 1883-97, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25468678
10.
Evidence for an early innate immune response in the motor cortex of ALS.
J Neuroinflammation
; 14(1): 129, 2017 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28651542
11.
Complementary feature selection from alternative splicing events and gene expression for phenotype prediction.
Bioinformatics
; 32(17): i421-i429, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27587658
12.
Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function.
Cereb Cortex
; 25(11): 4259-72, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25596590
13.
An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice.
PLoS Biol
; 10(6): e1001350, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22745599
14.
eGFP expression under UCHL1 promoter genetically labels corticospinal motor neurons and a subpopulation of degeneration-resistant spinal motor neurons in an ALS mouse model.
J Neurosci
; 33(18): 7890-904, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23637180
15.
TDP-43 protein interactome informs about perturbed canonical pathways and may help develop personalized medicine approaches for patients with TDP-43 pathology.
Drug Discov Today
; 28(11): 103769, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37714405
16.
Corticospinal motor neurons and related subcerebral projection neurons undergo early and specific neurodegeneration in hSOD1G9³A transgenic ALS mice.
J Neurosci
; 31(11): 4166-77, 2011 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-21411657
17.
AAV2 mediated retrograde transduction of corticospinal motor neurons reveals initial and selective apical dendrite degeneration in ALS.
Neurobiol Dis
; 47(2): 174-83, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22521461
18.
Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD+ balance as a therapeutic strategy.
Sci Rep
; 12(1): 4287, 2022 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35277554
19.
2-Year-Old and 3-Year-Old Italian ALS Patients with Novel ALS2 Mutations: Identification of Key Metabolites in Their Serum and Plasma.
Metabolites
; 12(2)2022 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35208248
20.
Expanded access: opening doors to personalized medicine for rare disease patients and patients with neurodegenerative diseases.
FEBS J
; 288(5): 1457-1461, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32805742